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tbpA

Victor ID 4057
Gene Name tbpA
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae L20
NCBI Gene ID 4849278
NCBI Protein GI 126209031
Locus Tag APL_1567
Genbank Accession CP000569
Protein Accession YP_001054256
Other Database IDs UniProtKB-ID: A3N2L5_ACTP2
UniRef100: UniRef100_A3N2L5
UniRef90: UniRef90_A3N2L5
UniRef50: UniRef50_A3N2L5
UniParc: UPI000045D740
EMBL: CP000569
EMBL-CDS: ABN74651.1
RefSeq_NT: NC_009053.1
GenomeReviews: CP000569_GR
KEGG: apl:APL_1567
eggNOG: COG1629
HOGENOM: HBG296544
OMA: EIEYENV
ProtClustDB: CLSK877571
BioCyc: APLE416269:APL_1567-MONOMER
Taxonomy ID 416269
Gene Starting Position 1793087
Gene Ending Position 1795894
Gene Strand (Orientation) -
Protein Name transferrin-binding protein 1 Tbp1
Protein pI 9.57
Protein Weight 101957.22
Protein Length 935
DNA Sequence 
>gi|126207488:1793087-1795894 Actinobacillus pleuropneumoniae L20, complete genome
ATTAGAATTTCATTTCGAATGAAACAACATAATTTCTACCGGGCGCTGCATACCTTGCATAGTCTTTTAC
GTTAGTATGCTGATGAATTGCATTAAGCGAAGATTGACGTACGGATTCCCAAGTGGTGTAACGATAATTC
ATCAGGTTATATACGCCAGCTCGTACCGTTGTATGTTTCCAAGGGGTGATATATCCCGTTAAGTCAAAGG
TATGCCAAGAACGTGTTCTTTTCTTCGTGGCAGTTCGCTCATAATTGGCAAAACCGACTTGTTCATTACC
TCTTAACTCATTTGGATTTTTTCCACTGGAGTGTGTCATTGTTAGATTCACGCCCCATTTTTCATCTGGC
TGATCGTACCCCACTCCTACAACATAGCGAGCAGGCTGAATGGTATCTAACAATGGAGAACGAATATTCA
TATACCCTTGATAGTTTTTCACCTCTTTTACTCGCATTTTGCTATAAGCCAATGTTGTGTAAATGCCCTC
AGGAATTTTATCAAATACCCCATTCCAATCTAGCTTACCAATAAGATTAATGCCGTCCAATTTAATATCT
TGCACATTAAAATAGTTAATCATTGATTGAGTTTGGTGCATTCTTTCTGCTGGAGCAATTAACTGCTTAT
AGTCATTTTTGAAATAACTGACTTCAACGACACCAAAATCACCTTTGAAAGTCGCAGCAACCTCTTGGTT
TAAGGATTTTTCAGGAGATAACTTCTCTGTTTTTTGGTAAGCATCGCTGGAGCCTTTCATTGCACCATCA
TAACGTAAGCCAAATAGCTCTTGGAAACTTGGCACTCTAAAGCCAGATGATGCTCGATAAGAGAGCGATA
GGAATGACGTTGGTTTTGCGACTATGCCAATATTCCACGCACTATTTTTATAATCGCCTTGATTTGCCCA
GCGATGAGTGCTACGGAATTTATGCTTATCGAAACGGTAACCCAAACCAATATCCAAATACTTGGTTATG
GCAAAATTATCTCTCAGAGCGATGTAGTGATTATGCCCTTTGATTTTACTTGTAGCACAATCAGCCCTAC
CTGCAATAGTGCCACTATAATCACATTCATTTTTACTATAAATTGCCTGATCTTTTAGCTCATACACATA
AGGATTATTGTAAGATCCATTTCGATAGCCAATGTCTCTAACAAGCCCCCAACTCCCTACAGAAAATTCA
CTCAAAATTTCATGGCGTTTTAAGGTGGAATTGAAACGGTCTGAACCTAATAACATATTTAATTGATGTT
TACCCAATCCCGTTTGTACGGTTTTATCTAACGAGAGCTGAATAGTGTCGTGTTTTTCTTCATAAGAACT
TTGCTCATTTTTAGTAGAAGACCAAAGTTTATCAAGAGTTGCACGGCAATTCTTATCTATGGTTGGATAT
TCCGAACAGTTGTTTTCTCTCAAGCGGGTAGATAAATTAATTTTTTGCTGATCGAAACTCAAGGATAGTC
TATCAATCAGACGATTTCCATCTTGATTAGTATAACGATATAAAGCACCTAAGCGATCACGAGTGTGCCA
CTCGTCAATAAAACGAGCTTTTGCCCAACGTAAACCTTTTGAGGATTTCACACCATCTTCCGTAAAGTAG
TCAATAGCAACACCATCTAAAGCATTATCACGATATAATCCTTTAGCATTATTCATTGGATACCAATTTC
TACCAGTTCTAAGTAAATCCGATGGTTGCCAATAAGCGGTATAGGTCATATCTCGGGTGTCGTAACGCTG
TTTGCTATGTTCATAAGTACCAGCGACATAATGTTTCGGAGAGAATGTGTATCCTAATTTAACCAGCCAA
GAATCAGATTTATATTTAAGCGGATCAGGTAAAGCTCTATATTCACCAGTGTAATCCTGAGCATTTAGAC
GCTCTGTAATATGTTTTTGGTTCTCATAAGCCTGTTTTTCCTCAGGAGTATATTCAGGGTAAGAACGGAA
AGATGGCGTATCTTTTGTCACCCTAGCCATCTGTTTCGGCGTACAATCTAACGTTGGACATTCATCTTTA
ATCAAAAACCAGCCATAAGTATGTTGATTATTCGTCGTCGCAGTATATCTATTTGAGGTATCAAGCTCGT
TGGTTTCCACTCCTACTCGGGTGATATTCTGAGAACGACTCTCTGCATTTTTATGAGCTTTCGTTTCCTT
ACCATCACGGTGAGTGTAAATCACAAGAGCATCAAAGCCATTGTGAGTACCAGCAAAAGCAAGTGAGTTT
AACCATTGTTGATTTTTGCTACTGTAGGCACTTTTGGTATCTAATCCCCAAGATTGCCCTGGCTTAATAA
TGTCGCTTACCTCTTTGGTACGGAATTGCACCGAACCGCCTAGTGAGCCACTACCAAACTCAGAAGAACT
AGCCCCTTTACTAATTTGGATCGAACGCAGATTTTCGTATTCTATTTCATTAATGGCACCGCTTGAGGAA
CGTGAATACTGGCTTACATAGGACTGAATCTGTGGTAAACCATCTAATGCCAAGCCAACACGGTTACGAT
CTACCCCACGAATTGAGTAGCCTGTAGTCGCACCTCTCCCTTGTTCTACGACAGAAATACCGGGGTCGTA
ACGAGTCAGATCTCGTATTCCTAACACTTGCTCCTTACTAAGAGTATCTGGTGTTTTAACTACTTTCCCT
AAGCCTGTGACTTCGTTCTCTTTTTTATGTGCTTTCTTTTTTGTTCCTGTGACATAAACATCGTTCAATT
GCACCGCTTGTTCTGCATAGCTTTGTACGGCAAAGAGGCTAAGCAGAGCAAGGCTAATCAGATTTAATTT
ATTTTTCA
Protein Sequence 
>gi|126209031|ref|YP_001054256.1| transferrin-binding protein 1 Tbp1 [Actinobacillus pleuropneumoniae L20]
MKNKLNLISLALLSLFAVQSYAEQAVQLNDVYVTGTKKKAHKKENEVTGLGKVVKTPDTLSKEQVLGIRD
LTRYDPGISVVEQGRGATTGYSIRGVDRNRVGLALDGLPQIQSYVSQYSRSSSGAINEIEYENLRSIQIS
KGASSSEFGSGSLGGSVQFRTKEVSDIIKPGQSWGLDTKSAYSSKNQQWLNSLAFAGTHNGFDALVIYTH
RDGKETKAHKNAESRSQNITRVGVETNELDTSNRYTATTNNQHTYGWFLIKDECPTLDCTPKQMARVTKD
TPSFRSYPEYTPEEKQAYENQKHITERLNAQDYTGEYRALPDPLKYKSDSWLVKLGYTFSPKHYVAGTYE
HSKQRYDTRDMTYTAYWQPSDLLRTGRNWYPMNNAKGLYRDNALDGVAIDYFTEDGVKSSKGLRWAKARF
IDEWHTRDRLGALYRYTNQDGNRLIDRLSLSFDQQKINLSTRLRENNCSEYPTIDKNCRATLDKLWSSTK
NEQSSYEEKHDTIQLSLDKTVQTGLGKHQLNMLLGSDRFNSTLKRHEILSEFSVGSWGLVRDIGYRNGSY
NNPYVYELKDQAIYSKNECDYSGTIAGRADCATSKIKGHNHYIALRDNFAITKYLDIGLGYRFDKHKFRS
THRWANQGDYKNSAWNIGIVAKPTSFLSLSYRASSGFRVPSFQELFGLRYDGAMKGSSDAYQKTEKLSPE
KSLNQEVAATFKGDFGVVEVSYFKNDYKQLIAPAERMHQTQSMINYFNVQDIKLDGINLIGKLDWNGVFD
KIPEGIYTTLAYSKMRVKEVKNYQGYMNIRSPLLDTIQPARYVVGVGYDQPDEKWGVNLTMTHSSGKNPN
ELRGNEQVGFANYERTATKKRTRSWHTFDLTGYITPWKHTTVRAGVYNLMNYRYTTWESVRQSSLNAIHQ
HTNVKDYARYAAPGRNYVVSFEMKF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tbpA mutant is attenuated in pigs (Baltes et al., 2002).
COG COG1629P, under P: Inorganic ion transport and metabolism
References
Baltes et al., 2002: Baltes N, Hennig-Pauka I, Gerlach GF. Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection. FEMS microbiology letters. 2002; 209(2); 283-287. [PubMed: 12007819].