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irp from Actinobacillus pleuropneumoniae L20

Victor ID 4051
Gene Name irp from Actinobacillus pleuropneumoniae L20
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae L20
NCBI Gene ID 4849145
NCBI Protein GI 126208395
Locus Tag APL_0919
Protein Accession YP_001053620.1
Other Database IDs UniProtKB-ID: A3N0S9_ACTP2
UniRef100: UniRef100_A3N0S9
UniRef90: UniRef90_B0BPK3
UniRef50: UniRef50_B8F3Y6
UniParc: UPI0000F28888
EMBL: CP000569
EMBL-CDS: ABN74015.1
RefSeq_NT: NC_009053.1
GenomeReviews: CP000569_GR
KEGG: apl:APL_0919
eggNOG: COG1629
HOGENOM: HBG367294
OMA: AHLAYHV
ProtClustDB: CLSK957416
BioCyc: APLE416269:APL_0919-MONOMER
Taxonomy ID 416269
Gene Starting Position 1059146
Gene Ending Position 1061494
Gene Strand (Orientation) -
Protein Name iron-regulated outer membrane protein
DNA Sequence 
>gi|126207488:1059146-1061494 Actinobacillus pleuropneumoniae L20, complete genome
TTTAGAATTTAACATTCACAACCAATATAAAATTCCGTCCCGTTTGCGGTACAAATTGGTGGTAAGAGGT
GTGAATATAGACCGGTTGGTTGAGTAAATTAGTACCGTTTAGACTGATTTTGTAATCCAAATCTTTCCAC
TTATTACTATATGCCACACCAATATTTAACATCGTATTACCTTCCGTAATATATTCCAACTGACTGGTAC
GGCGTTGAGTAAAGGTACGGATCAATTCTAAATCTCCTGACCAATTTGGGGTAAACTCCGCATTAAAACG
AAAACCTAGTCGTACAGGAGGGGTTCGAGGCGTATTTTGATCAGCACGATAAATCAAATAATCTTCACCT
GGTTTAGCATCTTTTGGTAAATAATCTTTAAATACGCTGTAATCGCTGTTTACCGTCAGTGGAGGTAAAT
TGGTCAGCCAGCCTCTTACCATATCACCAAAAATCGTAGCTTGGTATTTGTCGTTAAAGCGGTAGCTTGC
CTCAGCTTCTATGCCGTAAAAACGGGCTTTTGCCTGGTTATAACGACGCATAAATAACTGATTTTCACGG
AATAAATTTTCATTGTAAATGTAGTTTTTAAAGTGGTTGTAATAAACATTCACTTTGTACCCAACTCGCT
CAGTTTGATAACCTAAGCCTAGTTCTACATTGTTAGATTGCTCTTTTTTCAAATCTTTATTGCCGTATTC
AAACGAGTTAGTCGCAATATGCTGTCCATGATAATACAGCTCCATCGGCGTTGGGAAACGTTCATTATGC
GATGCAGTAAACGAGAGCTGATAATCTGGGTGGAAGAACCAATTTAGCGTACTGGAATAGGCATAAGCGT
TTTGGTTATAAGGTGACAGATCTGGCTCAACCTGTTTACCACCACTAATGCGATAATGATCCTGCAAGCG
TTTGATTTCATTGCGATCGTATTCAATTTCAATCTTCTGCTTTTCTACTCGTCCAGCAAATTCAAGAGCA
AAATTATCCCACATATATTGCTCAATACCAAACAGGCTCATCTGTTTATTCGTGTTTTCAACCAGCGGGA
ATTTCACTTCACGATCTTTCGGTGCATGCATGCTGCTCTTCTGAGTTTGGTACTGCACGCCCCATACACC
GGTTAAACCACCTAGTGGTGCATGATAGATTTCCAAGCGGGCATTTTTGCCTCGATTTTTGAAAATATTG
ACCGGTTTGCCATAATCCTGATCTTTTTTCAGCTGTTTATGGTAGCGTGTTGCTAACACACCGGCATCTT
TTTCGTCATGGTAATAATCGGCATCGGCGTAGCTTACTTTAATTTTATCAATACCTTTGAATGGCTGACG
CAACTCGGCTTTTACATCAAATCGTTTGGATTCTAAATCAACCCATGGACCAGGGTGTGTATGGTCGTGA
TCGTGTTCGAATGGATTATCGTGGCTGTGTGTACCATCTTCTGCATGATCAGTTCCACAGTGGAAATGCG
GATTGCTCCCAATGTTTTCCTCGCCAATCAAATGCGGATAGAGATAGGTATAGGCGTATTTGCCCTGTTT
ATTGCCATAAATATGTCCAATACAGAAATCGAATTTATGGTTATGCCCTGGTAAGCCATAGTTATCCCGC
CGTTTACTGTATGACGCACCGATATAACCTTGCTCACCAACAAAGGATAACCCTAACGTGCCGACTTTTG
ATTTATTATAAGTATCCGGGACATAGTTTAACCGTTCACCTAAATTAATCCCTGGAACACGGTAGTTATC
GCTGTGGCGGGTCAGTCCTTCGGCTCGCACCGCAATATGTTTGCCGATACCAAAGGTTGCCCCTAATGCG
CCGACTTTCTCTTTGGCAGCGGTATCAAAACGGCTATTGAGTTCCACCTCATAGCCCTTTTCTGGGATCT
CAGTTGGAATACGTTTATCTACCACGTTCACAATCCCCGCCGGTGAACTGCTGGCATAAAGCAAGGTACT
GGAACCACGCAAAATTTCTACCTGTTTAGCAAGCAATGAATCGGCAACCACCGCATGATCTGGCGATAGG
TTTGACATATCAATCACATCCGAACCGTTTTGCAGAATACGAATTCTCGCGCCTTCTTGGCCACGGATAA
TTGGCTTACTCGCGCCACCGCCAAACGGGTTACTGTGTACACCTAACTCCGCTGCAAGCGCATTGCCCAG
CGTTGCCGAACGCTTTTTAAATTCCTTACCTGCAATAATTTTATCACTGACTTTCAGTAAGGTAACTTCA
CTTCCTTGCGAAATACTCGGCGTGCTACCAACTACTGAAACTTCGTCTAACACTGCAACATCGTTATTGT
TTGCCCAAACAAGCGGGCTAAATTGGGCTGAAATCAACA
Protein Sequence 
>gi|126208395|ref|YP_001053620.1| iron-regulated outer membrane protein [Actinobacillus pleuropneumoniae serovar 5b str. L20] MLISAQFSPLVWANNNDVAVLDEVSVVGSTPSISQGSEVTLLKVSDKIIAGKEFKKRSATLGNALAAELGVHSNPFGGGASKPIIRGQEGARIRILQNGSDVIDMSNLSPDHAVVADSLLAKQVEILRGSSTLLYASSSPAGIVNVVDKRIPTEIPEKGYEVELNSRFDTAAKEKVGALGATFGIGKHIAVRAEGLTRHSDNYRVPGINLGERLNYVPDTYNKSKVGTLGLSFVGEQGYIGASYSKRRDNYGLPGHNHKFDFCIGHIYGNKQGKYAYTYLYPHLIGEENIGSNPHFHCGTDHAEDGTHSHDNPFEHDHDHTHPGPWVDLESKRFDVKAELRQPFKGIDKIKVSYADADYYHDEKDAGVLATRYHKQLKKDQDYGKPVNIFKNRGKNARLEIYHAPLGGLTGVWGVQYQTQKSSMHAPKDREVKFPLVENTNKQMSLFGIEQYMWDNFALEFAGRVEKQKIEIEYDRNEIKRLQDHYRISGGKQVEPDLSPYNQNAYAYSSTLNWFFHPDYQLSFTASHNERFPTPMELYYHGQHIATNSFEYGNKDLKKEQSNNVELGLGYQTERVGYKVNVYYNHFKNYIYNENLFRENQLFMRRYNQAKARFYGIEAEASYRFNDKYQATIFGDMVRGWLTNLPPLTVNSDYSVFKDYLPKDAKPGEDYLIYRADQNTPRTPPVRLGFRFNAEFTPNWSGDLELIRTFTQRRTSQLEYITEGNTMLNIGVAYSNKWKDLDYKISLNGTNLLNQPVYIHTSYHQFVPQTGRNFILVVNVKF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: irp mutant is attenuated in competitive index experiment in pig infection model (Subashchandrabose et al., 2009).
COG COG1629P, under P: Inorganic ion transport and metabolism
References
Subashchandrabose et al., 2009: Subashchandrabose S, LeVeque RM, Wagner TK, Kirkwood RN, Kiupel M, Mulks MH. Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infection and immunity. 2009; 77(11); 4925-4933. [PubMed: 19703979].