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ilvI from Actinobacillus pleuropneumoniae L20

Victor ID 4042
Gene Name ilvI from Actinobacillus pleuropneumoniae L20
Sequence Strain (Species/Organism) Actinobacillus pleuropneumoniae L20
NCBI Gene ID 4848759
NCBI Protein GI 126208207
Locus Tag APL_0727
Protein Accession YP_001053432.1
Other Database IDs UniProtKB-ID: A3N091_ACTP2
UniRef100: UniRef100_A3N091
UniRef90: UniRef90_B0BP07
UniRef50: UniRef50_Q89AP7
UniParc: UPI0000F2846A
EMBL: CP000569
EMBL-CDS: ABN73827.1
RefSeq_NT: NC_009053.1
GenomeReviews: CP000569_GR
KEGG: apl:APL_0727
eggNOG: COG0028
HOGENOM: HBG323037
OMA: GAMNEMW
ProtClustDB: PRK06882
BioCyc: APLE416269:APL_0727-MONOMER
Taxonomy ID 416269
Gene Starting Position 835092
Gene Ending Position 836816
Gene Strand (Orientation) +
Protein Name acetolactate synthase 3 catalytic subunit
DNA Sequence 
>gi|126207488:835092-836816 Actinobacillus pleuropneumoniae L20, complete genome
AATGAAAAAACTTTCCGGAGCAGAAATGGTTGTTCAATCCTTGAAAGACGAAGGCGTAGAGTACGTTTTC
GGCTATCCGGGTGGTTCGGTATTAGATATTTATGATGCGATTCATACGCTGGATAATATTAACCACGTTC
TTGTGCGCCATGAGCAAGCCGCGGTCCATATGGCGGACGGTTACGCTCGCTCAACCGGTAAAGTCGGTTG
TGTATTAGTAACATCCGGTCCCGGTGCAACCAATGCGATCACAGGTATTGCCACCGCTTATGCCGATTCT
GTCCCGCTTGTGATCTTAACCGGTCAAGTGCCTTCCGCTTTAATCGGTACGGATGCTTTCCAAGAATGCG
ATATGCTCGGTATTTCACGCCCTGTGGTTAAACACAGTTTTATGATCAAAAATCCGGAAGATATTCCTTC
AATAATCAAAAAAGCCTTTTATATTGCTTCAACCGGTCGCCCCAGTCCGGTCTTAATTGATATTCCGAAA
GATATGGTAAATCCGGCGAATAAATTTACCTATGAATATCCGAAAGAAGTCTCACTACGTTCATATAACC
CGACCGTACAAGGCCATAAAGTGCAAATTAAAAAGGCATTAAAAGCCCTATTAGTGGCAAAAAAACCGGT
TTTATACATTGGTGGAGGGATTATCTCTGCGGAATGTGCAACGCAACTTACCGACTTTGCAACGAAGTTA
AACTTACCGGTAACCAGTTCGTTAATGGGCTTAGGCGCTTTCCCTGCATCAAACAAACAATTTTTAGGTA
TGCTCGGTATGCACGGTACTTACGAAGCGAATAACGCAATGCACGAAAGCGATTTGATTCTCGGCATTGG
CGTACGTTTTGATGACCGTACCACGAATAATTTAGCAAAATATTGCCCGAATGCAAAAGTCATTCACGTG
GATATTGATCCGGCTTCTATTTCAAAAACCGTTCCGGCTTATATTCCGATTGTGGGTAGCGCAAAAAATG
TCTTGGAAGAATTTCTCAGCCTTTTAGAAGAAGAAAATCTTGCAAAAAATCAAGCGGATTTGACCGCTTG
GTGGCAACAGATTAATGAATGGAAAGCTCGTCAGTGCTTAAATTTTGAAGTAAGTAAAGATGTAATCAAA
CCGCAGCAAGTCATTCGATTAATTCATAAAATTACCAATGGTGATGCCTATGTTGCTTCGGATGTCGGTC
AGCACCAAATGTTTGCCGCACTCCATTATCCGTTTGAAAAACCTCGTCGCTGGATCAACTCGGGCGGAGC
CGGTACCATGGGATTCGGTTTACCGGCAGCAATCGGCGTAAAATTCGCCCATCCGGAAGCAACTGTAGTA
TGTGTAACCGGTGACGGCTCGATTCAGATGAATATTCAAGAGCTTTCTACGGCGAAACAATATGATACGC
CGGTTGTGATTGTGAGCTTAAACAATCGCTTCTTAGGTATGGTGAAGCAGTGGCAAGATCTGATCTACTC
CGGTCGCCATTCACAGGTATATATGAATTCACTGCCTGATTTTGCCAAATTAGCCGAAGCTTACGGTCAT
GTCGGCATTACGATTGATCACCCGAACGAATTGGAAGAAAAACTCACCCAAGCCTTTGCTATCAAAGACA
AATTAGTGTTTGTCGATGTAAAAGTAGATGAAACCGAACACGTTTACCCGATGCAAATTCGCGGCGGTGC
GATGAATGAGATGATTTTAAGCAAAACGGAGAGAACAGATGCGTA
Protein Sequence 
>gi|126208207|ref|YP_001053432.1| acetolactate synthase 3 catalytic subunit [Actinobacillus pleuropneumoniae serovar 5b str. L20] MKKLSGAEMVVQSLKDEGVEYVFGYPGGSVLDIYDAIHTLDNINHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITGIATAYADSVPLVILTGQVPSALIGTDAFQECDMLGISRPVVKHSFMIKNPEDIPSIIKKAFYIASTGRPSPVLIDIPKDMVNPANKFTYEYPKEVSLRSYNPTVQGHKVQIKKALKALLVAKKPVLYIGGGIISAECATQLTDFATKLNLPVTSSLMGLGAFPASNKQFLGMLGMHGTYEANNAMHESDLILGIGVRFDDRTTNNLAKYCPNAKVIHVDIDPASISKTVPAYIPIVGSAKNVLEEFLSLLEEENLAKNQADLTAWWQQINEWKARQCLNFEVSKDVIKPQQVIRLIHKITNGDAYVASDVGQHQMFAALHYPFEKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDTPVVIVSLNNRFLGMVKQWQDLIYSGRHSQVYMNSLPDFAKLAEAYGHVGITIDHPNELEEKLTQAFAIKDKLVFVDVKVDETEHVYPMQIRGGAMNEMILSKTERTDA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvl mutant is attenuated in pigs (Subashchandrabose et al., 2009).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Subashchandrabose et al., 2009: Subashchandrabose S, LeVeque RM, Wagner TK, Kirkwood RN, Kiupel M, Mulks MH. Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine. Infection and immunity. 2009; 77(11); 4925-4933. [PubMed: 19703979].