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supX

Victor ID 4029
Gene Name supX
Sequence Strain (Species/Organism) Yersinia enterocolitica subsp. enterocolitica 8081
NCBI Gene ID 4715471
NCBI Protein GI 123442459
Locus Tag YE2199
Protein Accession YP_001006438.1
Other Database IDs UniProtKB-ID: A1JPS1_YERE8
UniRef100: UniRef100_A1JPS1
UniRef90: UniRef90_A1JPS1
UniRef50: UniRef50_Q9KRB2
UniParc: UPI0000EB5646
EMBL: AM286415
EMBL-CDS: CAL12268.1
RefSeq_NT: NC_008800.1
GenomeReviews: AM286415_GR
KEGG: yen:YE2199
NMPDR: fig|630.2.peg.2143
eggNOG: COG0550
HOGENOM: HBG512935
OMA: VDIENNY
ProtClustDB: PRK09001
BioCyc: YENT393305:YE2199-MONOMER
Taxonomy ID 393305
Gene Starting Position 2409235
Gene Ending Position 2411850
Gene Strand (Orientation) -
Protein Name DNA topoisomerase I
DNA Sequence 
>gi|123440403:2409235-2411850 Yersinia enterocolitica subsp. enterocolitica 8081, complete genome
CCTATTTTTTAGCTTCAACCCATTTGCCATCAATATAGAAAGCAGACCAACCGGTGGCTTTGCCCTCTTT
CTCTGAGGAAACATATTGTTGCTTGGTTTTGCGGCTAAAGCGAACCAGAGTCTTATTACCTTCATTATCC
GTCACTGGCGCATCAGCCAGGTAGCGTAATTTTTCCGGTAAACGATCCTTGAAACGCACTAACTCTTCAA
CCAAAGGCGCACGTGTTTCACGCGATTTCGGGAATGTATTAGCCGCCAGGAAGACACCAGCAGCGCCATC
GCGTAACACGAAATAGGCGTCTGACTTTTCGCAAGGCAATTCTGGCAACGGTACCGGATCCTCTTTCGGC
GGTGCAACTTCACCACTACGCAAGATTTTACGCGTATTTTTGCACTCATCATTGGTACAACCCATGTACT
TACCAAAACGCCCCATTTTCAGATGCATTTCAGAACCACATTTCTCGCACTCAACAATCGGGCCTTCATA
CCCTTTGATACGGAACTCGCCTTCTTCAATCTCATAACCATCACATGTCGGGTTATTACCACAAACATGT
AACTTACGTTGGTTATCAATTAGATAACTATCCATTGCCGTGCCACACTTCTGACAACGACGTTTGGCGC
GTAATGCGTTAGTTTCTGCATCATCGCCTTCCAGGATATTAAGAATTTCAGCTTCCGGCACCAGATTGAT
GGTAGTTTTGCAGCGCTCTTTCGGCGGCAATGCATAGCCAGAACAACCGAGGAATACCCCAGTACTGGCA
GTGCGAATCCCCATCTGACGACCACAGGTTGGGCAATCGATGCTGGTCATGACCATTTGATTCGGGCGCA
TACCGCCCTCTTCAGGATCTTTTTCAGCCTTTTCAAGCTGCTCACTGAACTCAGCAAAGAAGCCGTCCAG
CACAGCCTTCCACTCAGCCTGATCATTAGCAACCTGGTCCAGGCCACTTTCCATGCGCGCGGTAAAGTCG
TAATTCATCAACTCGCGGAAGTTTTCTTCCAGACGGTCGGTGACGATCTCCCCCATTTTCTCGGCATAGA
AACGGCGGTTTTCTACCCGGACATAACCACGGTCCTGAATGGTCGAGATAATCGACGCATAAGTAGACGG
GCGGCCAATGCCCCGTTTTTCCAGTTCTTTTACCAATGACGCTTCGCTGTAACGCGCCGGCGGTTTGGTG
AAGTGCTGGCTTGGGATCAGTTTTTGTAAATCCAACTCACTGCCCACTTCGATCACTGGCAAGGTTCGGT
CTTCATCGCCTTTGCGCAATGCTGGCATCACCTTGGTCCAACCATCAAAGCGTAAAGTACGACCTTTAGC
TCGCAGTTGGAAATCGCCAGCCTGTACCGTCAGCGTGGTGGAGTCATACTTGGCTGGCGTCATCTGGCAA
GCCACAAACTGACGCCAAATCAGCTGATAAAGCTTCTGGGCGTCAGCTTCCATATCTTTTAGCTGCTCAG
CCATCACATTCACATCAGACGGACGAATGGCTTCATGCGCTTCTTGTGAATTTTCTTTGCTGCTGTATTG
ATTCGGTGCAGATGGCAAGTATTTATCGCCAAAATTATCACCAATATAACCGCGCACCATAGTCAGAGCA
TCCTGACTTAAGTTGGTGGAGTCAGTACGCATATAGGTGATATGCCCAGCTTCATACAAGCGCTGCGCCA
TCATCATGGTTTTCTTCACACCAAAGCTCAGGCGGGTACTGGCAGCCTGCTGCAAGGTAGAAGTAATAAA
TGGTGCACCGGGCTTGCTGCTGGTCGGTTTATCTTCGCGATCCAGCACTTTATAACGGGCGTTTTCCAGC
AGTTTAAGCGCGGCGTGGGTCTGCTCACGATTGACGGGTTTGAACGGCTTATTGTGAGCATGGGTGACTT
CCATTTGAATAGGAACTTCACCTTTTGCCAGCAAATCGGCATGCAATTCCCAATACTCTTCAGGAACGAA
TGCTTTAATATCCCGCTCACGTTCAACGACCAAACGTACCGCGACCGATTGTACGCGCCCAGCGGACAGG
CCACGTGCAATCTTTTTCCACAACAGTGGAGAAACCATATAACCCACAACCCGGTCCATAAAGCGACGGG
CTTGCTGGGCATTCACCCGGTTGATATTCAATTCACCCGGTTGATTAAATGCCTGTTGGATAGCATTCTT
CGTGATTTCGTTAAACACCACTCGACTAAAACGCTTATCGTCACCACCAATCACTTCCCGCAAATGCCAG
GCAATTGCCTCTCCTTCGCGGTCAAGGTCGGTTGCGAGATAGATGTGATCAGCGTTTTCGGCTAATGCTT
TCAGCTCGGCAACCACTTTTTCTTTACCGGGCAAAATTTCATACTGCGCTTTCCAGCCATGATAAGGATC
GACGCCCATGCGATTAACTAATGCAACCTTTTCGTCTTTCTTTACTTTAGTTTTGGGCTTGTCGGCTTTC
TTGGCTTTATCTTCAGTTGAGTTAGCGCTCTTCTTACTGGCTGAGCCACTGGTCGGCAAATCACGAATGT
GACCGACGCTGGACTTAACCACGTAGTTATTCCCTAAGTATTTATTAATAGTTTTGGCTTTTGCCGGGGA
CTCAACTATTACGAGAGCTTTACCCA
Protein Sequence 
>gi|123442459|ref|YP_001006438.1| DNA topoisomerase I [Yersinia enterocolitica subsp. enterocolitica 8081] MGKALVIVESPAKAKTINKYLGNNYVVKSSVGHIRDLPTSGSASKKSANSTEDKAKKADKPKTKVKKDEKVALVNRMGVDPYHGWKAQYEILPGKEKVVAELKALAENADHIYLATDLDREGEAIAWHLREVIGGDDKRFSRVVFNEITKNAIQQAFNQPGELNINRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVERERDIKAFVPEEYWELHADLLAKGEVPIQMEVTHAHNKPFKPVNREQTHAALKLLENARYKVLDREDKPTSSKPGAPFITSTLQQAASTRLSFGVKKTMMMAQRLYEAGHITYMRTDSTNLSQDALTMVRGYIGDNFGDKYLPSAPNQYSSKENSQEAHEAIRPSDVNVMAEQLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVQAGDFQLRAKGRTLRFDGWTKVMPALRKGDEDRTLPVIEVGSELDLQKLIPSQHFTKPPARYSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRELMNYDFTARMESGLDQVANDQAEWKAVLDGFFAEFSEQLEKAEKDPEEGGMRPNQMVMTSIDCPTCGRQMGIRTASTGVFLGCSGYALPPKERCKTTINLVPEAEILNILEGDDAETNALRAKRRCQKCGTAMDSYLIDNQRKLHVCGNNPTCDGYEIEEGEFRIKGYEGPIVECEKCGSEMHLKMGRFGKYMGCTNDECKNTRKILRSGEVAPPKEDPVPLPELPCEKSDAYFVLRDGAAGVFLAANTFPKSRETRAPLVEELVRFKDRLPEKLRYLADAPVTDNEGNKTLVRFSRKTKQQYVSSEKEGKATGWSAFYIDGKWVEAKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: topA mutant is attenuated in mice (Darwin and Miller, 1999).
COG COG0550L, under L: Replication, recombination and repair
References
Darwin and Miller, 1999: Darwin AJ, Miller VL. Identification of Yersinia enterocolitica genes affecting survival in an animal host using signature-tagged transposon mutagenesis. Molecular microbiology. 1999; 32(1); 51-62. [PubMed: 10216859].