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carB from Vibrio cholerae M66-2

Victor ID 3877
Gene Name carB from Vibrio cholerae M66-2
Sequence Strain (Species/Organism) Vibrio cholerae M66-2
NCBI Gene ID 7773573
NCBI Protein GI 227082512
Locus Tag VCM66_2312
Protein Accession YP_002811063.1
Other Database IDs UniProtKB-ID: C3LQT4_VIBCM
UniRef100: UniRef100_Q9KPH9
UniRef90: UniRef90_Q7MNU0
UniRef50: UniRef50_Q9ZKT2
UniParc: UPI0000126FA7
EMBL: CP001233
EMBL-CDS: ACP06612.1
RefSeq_NT: NC_012578.1
GenomeReviews: CP001233_GR
KEGG: vcm:VCM66_2312
OMA: ATVHSVW
ProtClustDB: PRK05294
Taxonomy ID 579112
Chromosome No I
Gene Starting Position 2491063
Gene Ending Position 2494293
Gene Strand (Orientation) -
Protein Name carbamoyl-phosphate synthase, large subunit
DNA Sequence 
>gi|227080237:2491063-2494293 Vibrio cholerae M66-2 chromosome I, complete genome
ATTAAGCTTGGTTCGCTTTTACACGCGCATGCAGCTCTTGTACTGAAGTGACGGATGCTTTGGCATCCGC
CGTGTGTGACATACAAGTTGCGAAGGCGGCGTTCAGTGTGGTGGTGTAGTTCACTTTGTGAGCCAATGCA
CCACGGCGCAGTACTTTTGAGTCTTCAATTGCTTGGCGGCCAGAAGCCGTGTTCACAATGTAGGTGTACT
CGTGGTTTTTGATGCGATCCAGAATGTGTGGACGACCTTCATGCACTTTGTTAACCAGACGTGGGTTGAT
GCCCGCTTCGCCCAGAATCACTGCAGTACCGTGAGTCGCATCCAACTGGTAACCCAGTTTCACTAGCTTA
GAAGCCAGATCCACTACACGCTGTTTGTCACCTTCACGCACCGAAAGTAGCGCACGACCACCTTCAGGGT
AAACCGAGCCACAGCCCAACTCTGCTTTAGCATAGGCTTCAGCAAACGTGGCACCCACACCCATCACTTC
ACCGGTTGAGCGCATTTCAGGGCCAAGCAGTGGGTCAACCCCCGGGAACTTGTTGAACGGCAGAACCACT
TCTTTAACTGAGTAGTAAGGTGGAATGATCTCTTTGGTGAAGCCTTGTTGCTCCAGAGTTTGTCCAACCA
TCACGCGCGCCGCGATTTTCGCCAGCGGAGCACCGGTTGCTTTAGAAACAAACGGCACAGTACGCGCAGC
ACGTGGGTTTACTTCAATCAGGTAAACTTCGTTGTCTTTGACTGCAAACTGAATGTTCATCAGGCCACGA
ACACCGAGTTCAAATGCCAACTTCTCAACTTGCTCACGCATCTTGTCTTGGATTTCTTGGCTCAAGGTGT
AAGCCGGCAGAGAACAGGCTGAGTCACCTGAGTGAACACCCGCTTGTTCAATGTGCTCCATGATGCCGCC
AATCACCACGCGCTCACCGTCACAAATCGCATCCACGTCCACTTCGGTTGCATCATCAAGGAAGCGATCC
AGCAGAACTGGTGATTCATTCGACACGCTCACCGCTTCGTTGAAGTAACGACGCAGATCTTGCTCATCGT
ACACAATCTCCATCGCACGGCCACCCAGAACATAAGAGGGGCGAACTACGAGTGGGAAACCGATTTCACG
CGACTTCTCAATCGCTTGCTCGATAGCGGTTACGGTTGCGTTGTCTGGCTGTTTGAGGCCTAAACGCTGT
ACCGCTTGTTGGAAACGTTCACGGTCTTCAGCGCGGTCAATCGCATCTGGGCTGGTACCAATCACAGGTA
CGCCAGCCGCTTCCAGCGCTCGCGCCAGTTTCAGTGGTGTTTGACCGCCGTACTGCACGATCACGCCTTT
TGGCTTCTCAACACGCACGATAGCCAGCACATCCTCTAGAGTTACAGGCTCAAAGTAGAGGCGATCTGAG
GTGTCGTAATCGGTTGATACGGTTTCTGGGTTACAGTTAACCATGATGGTTTCGTAACCATCTTCACGCA
GTGCAAGCGCGGCGTGTACACAGCAGTAGTCAAACTCGATACCTTGACCGATACGGTTTGGACCACCGCC
CAGCACCATGATCTTGTCTTTGTCAGTCGGATTGGCTTCACACTCTTCATCATACGTGGAGTACATGTAA
GCCGTATCTGACTTAAATTCTGCCGCGCAGGTATCCACACGCTTGTAAACTGGGTGGATGTTGTATTGGT
CACGCAGACGACGGATTTCGTTTTCGCTCACGCCGAGCAGTTTTGACAAACGCGCATCAGAGAAGCCTTT
GCGCTTCATCTTACGCAGTACGTCTTGGTTCAAGCCCGCAAAGCCACCGGCTTTCACTTCGGCTTCCAGC
TTCACCAGTTCTTCAATTTGCACTAGGAACCAGCGATCGATGTTGGTCAGGTTAAATACCCCATCCACTG
ACATACCGGCACGGAATGCATCCGCGATGTACCAAATACGCTCTGCGCCTGCTTCTTTCAGCTCATAACG
AATTTTGGTCAGAGCGTCTGGCGCGTCCAGATCCACTTTCTCATCCAGACCAGCCGCACCCACTTCCAAG
CCGCGCAGTGCTTTTTGCAGTGATTCTTGTTGGTTACGACCAATCGCCATCACCTCACCTACTGACTTCA
TTTGTGTAGTCAGACGGTCATTGGCACCGGCGAATTTTTCGAAGTTGAAACGAGGGATCTTAGTGACCAC
GTAGTCGATGGTCGGTTCGAACGAGGCTGGTGTTGCGCCGCCTGTGATGTCGTTCATCAACTCATCCAGA
GTGAAACCCACTGCCAGTTTGGCCGCCACTTTCGCAATTGGGAAACCGGTGGCTTTTGAAGCCAACGCAG
AAGAGCGCGATACACGTGGATTCATCTCGATGATCACCATGCGGCCATCTTTCGGGTTGATACCAAACTG
AACGTTTGAACCGCCGGTTTCTACGCCGATTTCACGCAGTACCGCCAAAGAGGCGTTACGCATGATTTGG
TATTCTTTGTCAGTTAGCGTTTGCGCTGGAGCGACAGTGATCGAGTCACCCGTGTGGATGCCCATTGGGT
CGAAGTTTTCAATCGCACAGACGATGATGCAGTTATCGTTCTTATCACGCACCACTTCCATCTCGTACTC
TTTCCAACCAATCAGTGATTCATCGATCAGCAGTTCATTGGTCGGTGAAAGATCCAGACCGCGAGTACAG
ATTTCTTCAAACTCTTCACGGTTGTAAGCGATACCACCACCGCTGCCGCCCATGGTGAAAGAAGGACGGA
TGATACATGGGAAGCCAACCATATCGAGGACTTTGTACGCTTCTTCCATGCTTTTTGCGGTATCAGCGCG
AGGACACTCTAGGCCGATTGATTTCATCGCTTTATCAAAGCGTGAGCGGTCTTCCGCTTTATCAATCGCA
TCGGCGGTTGCGCCGATCATCTCAACGCCAAACTCAGCCAATACGCCATGTTTTTCGAGTGCCAGCGCAC
AGTTCAGCGCAGTCTGGCCGCCCATGGTGGGCAAAATCGCATCTGGGCGCTCTTTTTCGATGATCTTACG
CACCACTTCCCAGTGGATAGGCTCGATGTAAGTCGCATCGGCCATTTCTGGGTCAGTCATGATGGTCGCT
GGGTTTGAGTTAACCAGAATAACGCGGTAACCCTCTTCGCGCAGGGCTTTACACGCTTGCGCGCCTGAGT
AGTCAAACTCACAAGCCTGACCGATAACAATTGGACCCGCACCAAGGATAAGGATGCTTTGAATGTCAGT
ACGTTTTGGCA
Protein Sequence 
>gi|227082512|ref|YP_002811063.1| carbamoyl phosphate synthase large subunit [Vibrio cholerae M66-2] MPKRTDIQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAILPTMGGQTALNCALALEKHGVLAEFGVEMIGATADAIDKAEDRSRFDKAMKSIGLECPRADTAKSMEEAYKVLDMVGFPCIIRPSFTMGGSGGGIAYNREEFEEICTRGLDLSPTNELLIDESLIGWKEYEMEVVRDKNDNCIIVCAIENFDPMGIHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVETGGSNVQFGINPKDGRMVIIEMNPRVSRSSALASKATGFPIAKVAAKLAVGFTLDELMNDITGGATPASFEPTIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNQQESLQKALRGLEVGAAGLDEKVDLDAPDALTKIRYELKEAGAERIWYIADAFRAGMSVDGVFNLTNIDRWFLVQIEELVKLEAEVKAGGFAGLNQDVLRKMKRKGFSDARLSKLLGVSENEIRRLRDQYNIHPVYKRVDTCAAEFKSDTAYMYSTYDEECEANPTDKDKIMVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLAIVRVEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQQAVQRLGLKQPDNATVTAIEQAIEKSREIGFPLVVRPSYVLGGRAMEIVYDEQDLRRYFNEAVSVSNESPVLLDRFLDDATEVDVDAICDGERVVIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDKMREQVEKLAFELGVRGLMNIQFAVKDNEVYLIEVNPRAARTVPFVSKATGAPLAKIAARVMVGQTLEQQGFTKEIIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGATFAEAYAKAELGCGSVYPEGGRALLSVREGDKQRVVDLASKLVKLGYQLDATHGTAVILGEAGINPRLVNKVHEGRPHILDRIKNHEYTYIVNTASGRQAIEDSKVLRRGALAHKVNYTTTLNAAFATCMSHTADAKASVTSVQELHARVKANQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: carB mutant is attenuated in mice (Merrell et al., 2002).
COG COG0458EF, under E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].