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purL from Vibrio cholerae M66-2

Victor ID 3859
Gene Name purL from Vibrio cholerae M66-2
Sequence Strain (Species/Organism) Vibrio cholerae M66-2
NCBI Gene ID 7772106
NCBI Protein GI 227081045
Locus Tag VCM66_0826
Protein Accession YP_002809596.1
Other Database IDs UniProtKB-ID: C3LTB9_VIBCM
UniRef100: UniRef100_Q9KTN2
UniRef90: UniRef90_Q9KTN2
UniRef50: UniRef50_Q1R8H7
UniParc: UPI0000132A60
EMBL: CP001233
EMBL-CDS: ACP05145.1
RefSeq_NT: NC_012578.1
GenomeReviews: CP001233_GR
KEGG: vcm:VCM66_0826
OMA: ERGIAYY
ProtClustDB: PRK05297
Taxonomy ID 579112
Chromosome No I
Gene Starting Position 889300
Gene Ending Position 893193
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|227080237:889300-893193 Vibrio cholerae M66-2 chromosome I, complete genome
CATGAGAATTTTGCGTGGCTCCCCAGCTCTTTCAGAGTTTCGTGTTAACAAGCTCCTGACCGCGTGTCGT
GAACAGCAACTGCCTGTAACCGGTATTTACGCCGAGTTTATGCACTTTGCCGATCTCAAGGCAGAGCTCA
ATCCGCAAGAGTTGGAAAAGCTCGAAAAACTGCTCACTTATGGTCCAACCATTCAAGAGCATGAACCGCA
AGGTTTACTGCTGTTGGTGACGCCGCGCCCCGGAACCATCTCACCTTGGTCCTCAAAAGCCACCGATATT
GCACACAACTGTGGCCTGCATGGCATCAAGCGCCTTGAGCGCGGTACGGCTTATTATGTTGAAGCAGAAA
CGGCGCTGACCGCAGCACAAATCGCAACACTTGAGGCGCTGCTGCATGATCGAATGATGGAAGTCGTGTT
CGCAGAACTCACCGATGCCCAGCAACTGTTCAGCGTAGCAGAGCCTGCGCCTATGAGTCAGGTCGATGTA
TTAGCGGGCGGTCGTCGTGCGCTTGAAGAGGCAAACGTTTCCCTTGGTCTGGCATTGGCTGAAGATGAAA
TTGATTATCTGGTTGAGAGCTTCACTAAACTGGGTCGTAATCCTAACGACATTGAACTGATGATGTTTGC
ACAGGCGAACTCAGAGCACTGCCGCCACAAGATTTTCAACGCCGATTGGACCATTGATGGGGTTAAGCAA
GACAAGTCACTGTTCAAAATGATCAAAAACACCTTTGAACAGACGCCGGATTATGTGCTTTCGGCTTATA
AAGATAATGCCGCAGTAATGACGGGCTCGACCGTTGGCCGTTTCTTCCCCGACCCCGAGAGCCGTCAGTA
CACTTATCACCATGAAGATGCCCACATTCTGATGAAAGTGGAAACGCATAACCACCCAACGGCGATTTCG
CCTTGGCCGGGGGCTTCGACTGGTTCTGGCGGTGAAATTCGTGATGAGGGCGCAACCGGTATTGGCGGCA
AGCCTAAAGCGGGATTGGTGGGCTTTACCACCTCGAACTTGCGTATTCCCGGTTTTGAACAGCCATGGGA
AAGCGATTTTGGTAAGCCAAGCCGCATTGTGAATGCGCTGGATATCATGCTGGAAGGGCCACTCGGCGGC
GCGGCGTTCAACAACGAATTTGGTCGCCCGAACCTACTTGGGTATTTCCGCACTTATGAAGAAAAAGTGA
CGTCACATGCTGGTGAAGAGGTGCGTGGTTATCACAAGCCGATCATGATTGCCGGCGGTATGGGTAACAT
TCGCGCCGAGCATATTCAGAAGAAAGAGATCCCAGTGGGGGCAAAACTGATCGTACTCGGAGGCCCTGCG
ATGAACATCGGTCTCGGTGGTGGCGCAGCCTCTTCGATGGCTTCTGGCCAGTCTGCTGAAGATCTGGATT
TTGCTTCTGTGCAGCGTGAAAACCCAGAGATGGAGCGCCGCTGTCAGGAAGTGATTGACCGTTGTTGGCA
GCTCGGTGACAAAAACCCGATCGCCTTTATCCACGATGTGGGCGCGGGTGGTATCTCTAACGCTCTGCCT
GAGCTGGTGAATGACGGCGATCGCGGTGGTAAATTCCAGTTGCGCAACGTGCCGAATGATGAGCCGGGCA
TGAGCCCATTGGAAATCTGGTGTAATGAATCACAAGAGCGTTATGTGCTGGCGGTTGCTGCGGAAGATAT
GCCGCTGTTTGATGCGATTTGCCAGCGTGAACGCGCCCCTTATGCCGTGGTAGGTGAAGCGACCGAAGAG
CGCCATTTGACGCTGGAAGACAGCCACTTTGCTAACACGCCGATTGATATGCCAATGGATATTCTGTTGG
GTAAGCCGCCGAAAATGCATCGTGAAGCGAGCACGCTGAAAGTTTCAAGCCCAGCGCTAGAGCGTTCAGG
CATTGAGCTTAATGAAGCGGTGGATCGCGTACTGCGTTTACCGGCAGTCGCAGAAAAAACGTTCCTGATC
ACCATTGGTGACCGCTCAGTGACTGGCTTAGTCGCGCGGGATCAAATGGTCGGCCCATGGCAAGTTCCCG
TCGCAAACTGCGCAGTAACGGCCGCGAGTTTTGATTCTTACCACGGCGAAGCGATGTCTATGGGTGAGCG
TACCCCTGTTGCGCTGTTGGATTTCGGTGCCTCTGCACGTTTAGCGGTCGGTGAAGCTATTACCAACATA
GCCGCAACCGATATTGGCGAGCTGAAACGCATCAAACTTTCGGCGAACTGGATGTCTCCAGCGGGCCATC
CGGGTGAAGATGCCGGTCTGTATGAAGCGGTGAAAGCGGTCGGTGAAGAGCTTTGTCCTGCACTGGGTAT
CACTATCCCAGTCGGTAAAGACTCGATGTCGATGAAAACCAAGTGGCAGGAAAATGGCGAGCAGAAAGAA
GTGACTTCGCCGCTGTCACTCATCATCACCGCCTTTGCACGTGTGGAAGACATTCGCAAGACCGTGACCC
CACAACTGCGTACTGACCTTGGTGAGACAAGCTTAATCTTGATTGACTTGGGGAATGGTCAAAATCGTCT
TGGCGCAACCGCATTGGCGCAAGTGTACAAACAGTTGGGTGATAAGCCGGCTGATGTGGATAACGCGGCG
CAGCTCAAAGGCTTTTTTGATGCAGTACAAACGCTGGTGCGTAACGACAAGCTGGTGGCTTACCACGACA
AAGGTGACGGCGGTTTATTGGTGACGTTGGCAGAAATGGCTTTCGCGGGTCACTGTGGTATTAAAGCCAA
TATTGAAACCTTGGGTGATGATGCACTGGCGGCACTGTTCAATGAAGAGCTTGGCGCCGTGGTTCAAGTG
AAAAATGATGAGCTGAATGCTGTTCTGGCAACACTTGCCGCCCATGGTTTAGAAGCGTGTGCTCACGTGA
TTGGTGAAGTAGAAGCATCCGATCGTCTGCTGATCACTTGTGGTGAGGAAGTCTTGATTGAGCGCTCTCG
TACTGAGCTTCGCACCATCTGGGCGGAAATGACCCATAAGATGCAAGCGCTGCGTGATAACTCGGCGTGT
GCTGATCAAGAGTTTGCGGCCAAACAAGATAACCGTGACCCGGGCTTGAATGCGAAGTTAACTTACGATG
TGCAAGCCGACGTTGCTGCGCCGTACATCGCCAAAGGTGTGCGTCCGAAAATGGCGATTTTGCGTGAGCA
AGGCGTCAACTCACACGTTGAGATGGCGGCAGCGTTTGACCGCGCTGGTTTTGATGCGGTTGATGTGCAT
ATGAGCGACATTCTGACTGGGCAAACCGTGCTCGATGCTTACCAAGGTCTGGTGGCTTGTGGTGGCTTCT
CTTACGGCGACGTACTGGGTGCGGGCGAAGGTTGGGCGAAATCGATTCTGTTTAACGCCCAAGCGCGTGA
GCAGTTTGAGCAGTTCTTCCAACGTAAAGATACTTTCTCACTTGGGGTGTGTAACGGCTGTCAAATGCTG
TCTAACCTGCGTGATTTGATCCCGGGTGCTGAGCTATGGCCACGTTTTGTGCGTAACGAATCGGATCGTT
TTGAAGCGCGCTTTAGCTTAGTCGAAGTGCAAAAATCGCCATCGCTGTTCTTTAGCGAGATGGCGGGCTC
AAGAATGCCGATTGCGGTTTCTCATGGTGAAGGTCGTGTGGAAGTGCGTGATGCTCAGCATCTGGCGGCA
ATTGAGCAATCTGGCACCGTAGCGATTCGTTTCGTGGATAACTTTGGTCAGCCAACCCAAGCTTACCCAA
GCAACCCGAACGGTTCACCGAATGCGATTACCGGTTTAACCACTCAAGATGGCCGTGTGACGATTATGAT
GCCGCACCCTGAGCGTGTATTCCGTACCGTCGCCAACTCGTGGCACCCTGATAACTGGGGTGAGAATGGC
GCTTGGATGCGTATGTTCCAGAATGCTCGTAAATATTTTGGCTA
Protein Sequence 
>gi|227081045|ref|YP_002809596.1| phosphoribosylformylglycinamidine synthase [Vibrio cholerae M66-2] MRILRGSPALSEFRVNKLLTACREQQLPVTGIYAEFMHFADLKAELNPQELEKLEKLLTYGPTIQEHEPQGLLLLVTPRPGTISPWSSKATDIAHNCGLHGIKRLERGTAYYVEAETALTAAQIATLEALLHDRMMEVVFAELTDAQQLFSVAEPAPMSQVDVLAGGRRALEEANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPESRQYTYHHEDAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWESDFGKPSRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDKNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRERAPYAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKMHREASTLKVSSPALERSGIELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYHGEAMSMGERTPVALLDFGASARLAVGEAITNIAATDIGELKRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQLGDKPADVDNAAQLKGFFDAVQTLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKANIETLGDDALAALFNEELGAVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLITCGEEVLIERSRTELRTIWAEMTHKMQALRDNSACADQEFAAKQDNRDPGLNAKLTYDVQADVAAPYIAKGVRPKMAILREQGVNSHVEMAAAFDRAGFDAVDVHMSDILTGQTVLDAYQGLVACGGFSYGDVLGAGEGWAKSILFNAQAREQFEQFFQRKDTFSLGVCNGCQMLSNLRDLIPGAELWPRFVRNESDRFEARFSLVEVQKSPSLFFSEMAGSRMPIAVSHGEGRVEVRDAQHLAAIEQSGTVAIRFVDNFGQPTQAYPSNPNGSPNAITGLTTQDGRVTIMMPHPERVFRTVANSWHPDNWGENGAWMRMFQNARKYFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in mice (Merrell et al., 2002).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].