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mxiG from Shigella flexneri 5a

Victor ID 38
Gene Name mxiG from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876497
NCBI Protein GI 13449083
Locus Tag pWR501_p144
Protein Accession NP_085299.1
Other Database IDs UniProtKB-ID: MXIG_SHIFL
UniRef100: UniRef100_P0A221
UniRef90: UniRef90_P0A221
UniRef50: UniRef50_P0A221
UniParc: UPI000012FAAF
EMBL: Z48957
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL-CDS: CAA88822.1
EMBL-CDS: CAC05811.1
EMBL-CDS: AAK18455.1
EMBL-CDS: AAL72329.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093247
EnsemblGenome_TRS: EBESCT00000094203
EnsemblGenome_PRO: EBESCP00000090410
GenomeReviews: AF386526_GR
KEGG: sfl:CP0136
HOGENOM: HBG683613
OMA: INQRFPY
P
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 111841
Gene Ending Position 112956
Gene Strand (Orientation) +
Protein Name Type III secretion protein
DNA Sequence 
>gi|13448939:111841-112956 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
TATGTCTGAGGCAAAGAACTCAAATCTTGCACCATTCAGGTTATTAGTGAAACTCACAAACGGTGTCGGG
GATGAGTTTCCGTTATATTATGGGAATAACTTAATTGTTCTCGGACGGACGATAGAAACACTTGAGTTTG
GAAACGACAATTTCCCAGAAAATATTATTCCTGTAACAGATAGTAAATCGGATGGTATAATTTATTTGAC
CATAAGCAAAGATAATATCTGTCAATTTAGTGATGAAAAAGGTGAGCAAATTGATATCAATTCACAATTT
AATTCATTTGAATATGACGGGATTTCTTTTCACCTTAAAAATATGAGGGAGGATAAATCGAGAGGCCATA
TACTAAACGGAATGTATAAGAACCACTCGGTGTTTTTTTTCTTTGCTGTTATTGTTGTGTTAATTATAAT
TTTTTCCCTCTCTTTAAAGAAAGATGAAGTAAAAGAAATTGCTGAAATTATAGATGATAAGAGATATGGA
ATAGTCAACACTGGACAGTGCAATTATATTCTTGCCGAAACACAAAATGATGCGGTATGGGCGTCTGTAG
CCTTAAATAAAACCGGATTTACCAAATGCAGATATATTCTGGTGTCAAACAAAGAAATAAATAGAATTCA
ACAATATATCAATCAACGATTCCCATTTATCAATTTGTATGTGTTGAATTTAGTGAGTGATAAAGCGGAA
TTACTGGTGTTTTTAAGTAAAGAAAGAAATAGTTCAAAAGATACCGAACTTGATAAATTGAAAAATGCTC
TGATTGTTGAATTTCCGTATATCAAAAATATTAAATTCAACTATCTTAGCGATCATAATGCAAGGGGGGA
TGCTAAAGGTATTTTCACAAAGGTAAATGTCCAGTATAAAGAGATTTGTGAAAATAATAAAGTTACATAT
TCTGTCAGAGAAGAACTGACAGATGAAAAGCTTGAGCTCATTAATAGACTGATTTCTGAACATAAAAATA
TATATGGAGATCAGTATATTGAGTTTTCTGTACTTTTGATAGATGATGATTTTAAAGGTAAATCATATCT
TAACAGCAAAGACAGTTATGTAATGTTGAATGATAAACACTGGTTTTTTTTAGATAAAAATAAGTG
Protein Sequence 
>gi|13449083|ref|NP_085299.1| Type III secretion protein [Shigella flexneri 5a str. M90T] MSEAKNSNLAPFRLLVKLTNGVGDEFPLYYGNNLIVLGRTIETLEFGNDNFPENIIPVTDSKSDGIIYLTISKDNICQFSDEKGEQIDINSQFNSFEYDGISFHLKNMREDKSRGHILNGMYKNHSVFFFFAVIVVLIIIFSLSLKKDEVKEIAEIIDDKRYGIVNTGQCNYILAETQNDAVWASVALNKTGFTKCRYILVSNKEINRIQQYINQRFPFINLYVLNLVSDKAELLVFLSKERNSSKDTELDKLKNALIVEFPYIKNIKFNYLSDHNARGDAKGIFTKVNVQYKEICENNKVTYSVREELTDEKLELINRLISEHKNIYGDQYIEFSVLLIDDDFKGKSYLNSKDSYVMLNDKHWFFLDKNK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: mxiG mutant was unable to enter HeLa cells and to provoke keratoconjunctivitis in guinea-pigs (Allaoui et al., 1995).
References
Allaoui et al., 1995: Allaoui A, Sansonetti PJ, Ménard R, Barzu S, Mounier J, Phalipon A, Parsot C. MxiG, a membrane protein required for secretion of Shigella spp. Ipa invasins: involvement in entry into epithelial cells and in intercellular dissemination. Molecular microbiology. 1995; 17(3); 461-470. [PubMed: 8559065].