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ipgD from Shigella flexneri 5a

Victor ID 37
Gene Name ipgD from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876495
NCBI Protein GI 13449080
Locus Tag pWR501_p141
Protein Accession NP_085296.1
Other Database IDs UniProtKB-ID: IPGD_SHIFL
UniRef100: UniRef100_Q07566
UniRef90: UniRef90_Q07566
UniRef50: UniRef50_Q07566
UniParc: UPI000012D7DF
EMBL: L04309
EMBL: AL391753
EMBL: AF348706
EMBL: AF386526
EMBL: AY206439
EMBL-CDS: AAA26517.1
EMBL-CDS: CAC05808.1
EMBL-CDS: AAK18452.1
EMBL-CDS: AAL72339.1
EMBL-CDS: AAP78996.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
EnsemblGenome: EBESCG00000093123
EnsemblGenome_TRS: EBESCT00000094079
EnsemblGenome_PRO: EBESCP00000090286
GenomeReviews: AF386526_GR
KEGG: sfl:CP01
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 109386
Gene Ending Position 111002
Gene Strand (Orientation) +
Protein Name secreted protein
DNA Sequence 
>gi|13448939:109386-111002 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
AATGCACATAACTAATTTGGGATTGCATCAGGTTTCATTTCAAAGCGGAGATTCCTATAAAGGCGCAGAA
GAAACCGGAAAGCACAAAGGTGTAAGCGTGATTTCATATCAAAGAGTTAAAAATGGAGAAAGAAATAAGG
GGATCGAAGCGCTTAATCGATTATATTTACAGAACCAAACAAGCTTAACAGGAAAAAGCCTTTTGTTTGC
GCGTGACAAAGCTGAAGTTTTTTGCGAGGCAATAAAGTTGGCAGGTGGTGATACGTCAAAAATTAAAGCC
ATGATGGAACGATTAGATACCTATAAACTTGGTGAAGTTAATAAAAGACATATTAATGAGCTTAATAAAG
TAATAAGTGAAGAGATAAGAGCACAGCTAGGCATTAAAAATAAAAAGGAATTGCAAACGAAAATAAAACA
AATATTTACTGATTATTTAAATAATAAGAATTGGGGACCGGTCAACAAGAATATTAGTCATCATGGGAAA
AATTATAGTTTTCAATTAACTCCTGCCTCTCATATGAAGATAGGGAATAAAAATATATTTGTCAAAGAGT
ATAATGGAAAAGGAATTTGTTGTGCTTCTACGAGAGAGCGTGATCATATCGCGAATATGTGGCTTTCAAA
AGTGGTGGATGACGAGGGGAAGGAAATTTTTTCGGGTATCAGACATGGAGTTATATCAGCCTATGGATTG
AAAAAAAACTCATCTGAAAGAGCTGTTGCTGCTCGTAATAAAGCTGAGGAGTTAGTAAGCGCAGCATTAT
ATAGCAGACCAGAGTTATTATCACAGGCTTTGTCTGGTAAAACAGTAGATTTAAAGATTGTTTCGACTTC
TCTTCTGACGCCGACCAGTTTAACCGGGGGAGAGGAGAGTATGTTAAAAGATCAGGTGAGCGCATTAAAA
GGGTTAAACTCTAAAAGGGGGGGGCCAACGAAATTATTAATTCGGAATAGTGATGGTCTTCTGAAAGAAG
TAAGCGTTAATCTAAAAGTGGTGACATTTAACTTTGGTGTAAATGAATTAGCGCTAAAAATGGGCTTAGG
CTGGAGGAATGTTGACAAGCTTAATGATGAATCAATATGTTCTTTGTTGGGGGATAATTTCCTCAAAAAT
GGTGTGATTGGAGGTTGGGCTGCAGAAGCAATAGAAAAAAATCCACCATGTAAGAATGATGTGATATATC
TGGCTAACCAGATAAAAGAGATTGTAAACAATAAGTTACAAAAAAATGATAATGGAGAGCCGTATAAATT
GTCACAAAGAGTGACTCTATTGGCTTATACTATAGGTGCTGTACCTTGCTGGAATTGTAAGAGTGGGAAG
GACAGAACAGGTATGCAGGATGCTGAAATTAAAAGAGAAATAATAAGAAAACATGAAACAGGTCAGTTTT
CTCAATTAAATAGTAAATTATCCTCAGAAGAGAAAAGATTATTTTCTACTATTCTAATGAATAGTGGTAA
TATGGAAATCCAAGAGATGAATACTGGTGTGCCCGGAAATAAAGTCATGAAAAAATTGCCGCTATCTTCG
TTAGAGCTATCTTATTCTGAAAGAATAGGGGACCCAAAAATATGGAATATGGTGAAAGGGTATTCGTCAT
TTGTATA
Protein Sequence 
>gi|13449080|ref|NP_085296.1| secreted protein [Shigella flexneri 5a str. M90T] MHITNLGLHQVSFQSGDSYKGAEETGKHKGVSVISYQRVKNGERNKGIEALNRLYLQNQTSLTGKSLLFARDKAEVFCEAIKLAGGDTSKIKAMMERLDTYKLGEVNKRHINELNKVISEEIRAQLGIKNKKELQTKIKQIFTDYLNNKNWGPVNKNISHHGKNYSFQLTPASHMKIGNKNIFVKEYNGKGICCASTRERDHIANMWLSKVVDDEGKEIFSGIRHGVISAYGLKKNSSERAVAARNKAEELVSAALYSRPELLSQALSGKTVDLKIVSTSLLTPTSLTGGEESMLKDQVSALKGLNSKRGGPTKLLIRNSDGLLKEVSVNLKVVTFNFGVNELALKMGLGWRNVDKLNDESICSLLGDNFLKNGVIGGWAAEAIEKNPPCKNDVIYLANQIKEIVNNKLQKNDNGEPYKLSQRVTLLAYTIGAVPCWNCKSGKDRTGMQDAEIKREIIRKHETGQFSQLNSKLSSEEKRLFSTILMNSGNMEIQEMNTGVPGNKVMKKLPLSSLELSYSERIGDPKIWNMVKGYSSFV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipgD mutant is unable to dephosphorylate phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] and induces shorter filapodia in host cells (Niebuhr et al., 2002).
References
Niebuhr et al., 2002: Niebuhr K, Giuriato S, Pedron T, Philpott DJ, Gaits F, Sable J, Sheetz MP, Parsot C, Sansonetti PJ, Payrastre B. Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. The EMBO journal. 2002; 21(19); 5069-5078. [PubMed: 12356723].