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ppsA

Victor ID 3670
Gene Name ppsA
Sequence Strain (Species/Organism) Burkholderia pseudomallei MSHR346
NCBI Gene ID 7889272
NCBI Protein GI 237812786
Locus Tag GBP346_A2540
Genbank Accession CP001408
Protein Accession YP_002897237
Other Database IDs UniProtKB-ID: C4KP65_BURPS
UniRef100: UniRef100_A3NAS6
UniRef90: UniRef90_A3NAS6
UniRef50: UniRef50_Q9K0I2
UniParc: UPI000043B27F
EMBL: CP001408
EMBL-CDS: ACQ98047.1
RefSeq_NT: NC_012695.1
OMA: ALIHFDE
ProtClustDB: PRK06464
Taxonomy ID 536230
Chromosome No I
Gene Starting Position 2471400
Gene Ending Position 2473799
Gene Strand (Orientation) -
Protein Name phosphoenolpyruvate synthase
Protein pI 5.1
Protein Weight 80824.57
Protein Length 799
Protein Note catalyzes the formation of phosphoenolpyruvate from pyruvate
DNA Sequence 
>gi|237810278:2471400-2473799 Burkholderia pseudomallei MSHR346 chromosome I, complete genome
ATTACTGCTTCGCGGCGAGCGCCTGCCACGTCTCGATGACCGTGTCCGGATTCAGCGAGATCGACGCGAT
GCCTTCGTCGGCGAGCCACTTCGCGAAATCCGGGTGATCGGACGGGCCCTGACCGCAGATGCCCACGTAC
TTGTCGAGCTTGCGACACGTGTCGATCGCGCGCTTCAACATGAACTTCACGGCCGGATCGCGTTCGTCGA
AATCGACGGCGAGCAGTTCCATGCCCGAATCGCGGTCGAGGCCGAGCGTCAGCTGCGTGAGGTCGTTCGA
GCCGATCGAGAAGCCGTCGAAGTGCTGCAGGAACTCCTCGGCGAGGATCGCGTTCGACGGCACTTCGCAC
ATCATGATGAGACGCAGGCCGTTGTCGCCGCGCTTCAGGCCGAACTTCCCGAGCAGGCCGACCACACGCT
CCGCCTGCTTCACGGTGCGCACGAACGGCACCATGATCTCGACGTTGGTCAGGCCCATTTCGTCGCGAAC
GCGCTTGAGCGCCATGCACTCCATCTCGAACGCCTGCGCGAAATCCTCGGCGATGTAGCGCGACGCGCCG
CGGAAACCCAGCATCGGGTTTTCCTCATCCGGCTCGTAGCGCGAGCCGCCGATCAGCTTCTTGTACTCGT
TCGACTTGAAGTCGGACAGACGCACGATCACGGGCTTCGGATAGAACGCCGCCGCGATCGTCGCGATGCC
TTCCGTCAGCTTGTCCACATAGAACGCCCGCGGCGACGCGTGGCCGCGCGCGACGCTCTCGACCGCCTTC
TTCAGGTCGGCGTCGACGTTCGGGTACTCGAGGATCGCCTTCGGATGCACACCGATGTTGTTGTTGATGA
TGAACTCGAGGCGCGCGAGGCCGACGCCCGCGTTCGGCAACTGCGAGAAGTCGAACGCGAGCTGCGGGTT
GCCGACGTTCATCATGATCTTGACCGGCACGCTCGGCAGCTCGCCGCGCTGCACCTCGGACACTTCGGTT
TCGAGCAGGCCGTCGTAGATCTTGCCCTCGTCGCCCTCCGCGCACGACACCGTGACGAGCGCGCCGTCCT
TCAGCACGTCGGTCGCGTCGCCGCAGCCGACCACCGCCGGCACGCCGAGCTCGCGCGCGATGATCGCCGC
ATGGCAGGTGCGCCCGCCGCGGTTCGTGACGATCGCCGACGCCCGCTTCATCACCGGCTCCCAGTTCGGG
TCGGTCATGTCGGCGACGAGCACGTCGCCCGGCTGCACACGCTCCATCTCCGACGGATCGTGGATCACGC
GCACGGGGCCCGCGCCGATCTTCTGGCCGATCGCGCGGCCCGTCGCGAGCACCTGCGACTGGCCCTTCAG
CTTGAAGCGCTGCTCGACCTTGCCGTGCGCCTGGCTCTTCACCGTTTCGGGACGCGCCTGCAGGATGAAG
ATCTTGCCGTCGCGGCCGTCCTTGCCCCACTCGATGTCCATCGGGCGCTGGTAGTGCTTCTCGATGATGA
CCGCGTACTTCGCGAGCTCGATCACGTCGTCGTCGGTGATCGAATAGCGGTTGCGCTGCTCGTGCGGCAC
GTCGACCGTCTTCACGCGGCCCGGCTCGCCCGGCTGCGTGAATTCCATCTTGATCAGCTTCGAGCCGATC
GAGCGGCGGATGATCGGGTACTTGTCCTGTGCGAGCGTCGTCTTGAACACATAGAACTCGTCCGGATTCA
CCGCGCCCTGCACGACGGTTTCGCCCAGGCCGTAGCTCGCGGTGATGAACACGGCGTCCTTGAAGCCCGA
TTCGGTGTCGATCGTGAACATCACGCCGGCCGCGCCGACGTCCGAGCGCACCATCCGCTGCACGCCGGCC
GACAACGCGACCTCGGCGTGCGTGAAGCCCTTGTGCACGCGGTACGAGATCGCGCGATCGTTGTACAGCG
ACGCGAACACGTGCTTCATGCGGTCGAGCACGTCCTCGATGCCGACGACGTTCAGATACGACTCCTGCTG
ACCGGCGAACGATGCGTCGGGCAAGTCCTCCGCGGTCGCGGACGAGCGCACGGCGAACGACAGCTCGCCC
GGCGAGCCGTTCTTCAGGATCTCGAACTGCGCGCGGATTTCCTGCTCGAGGCGCGGCTGCAGCGGCGCGT
CGACGATCCACTTGCGGATCTCGGCGCCGGCTTCGGCGAGCGCCTTCACGTCGTCGATGTCGAGCGACTC
GAGACGTTGCGCGATGCGTTCGGTGAGGTTGTTGTGCTGGAGAAAATCGCGGAATGCGAGCGCGGTCGTC
GCGAAACCGGTGGGCACGCGCACGCCTGCCTCGGCCAACTGGCTGATCATCTCGCCGAGCGACGCATTCT
TGCCGCCGACGATTTCGACATCGGTCATTCGCAACTGCTCGAACGGAATTACATACGCCTGATCCTTTGC
GACGTTTGCTGCGTTAGTCA
Protein Sequence 
>gi|237812786|ref|YP_002897237.1| pyruvate, water dikinase [Burkholderia pseudomallei MSHR346]
MTNAANVAKDQAYVIPFEQLRMTDVEIVGGKNASLGEMISQLAEAGVRVPTGFATTALAFRDFLQHNNLT
ERIAQRLESLDIDDVKALAEAGAEIRKWIVDAPLQPRLEQEIRAQFEILKNGSPGELSFAVRSSATAEDL
PDASFAGQQESYLNVVGIEDVLDRMKHVFASLYNDRAISYRVHKGFTHAEVALSAGVQRMVRSDVGAAGV
MFTIDTESGFKDAVFITASYGLGETVVQGAVNPDEFYVFKTTLAQDKYPIIRRSIGSKLIKMEFTQPGEP
GRVKTVDVPHEQRNRYSITDDDVIELAKYAVIIEKHYQRPMDIEWGKDGRDGKIFILQARPETVKSQAHG
KVEQRFKLKGQSQVLATGRAIGQKIGAGPVRVIHDPSEMERVQPGDVLVADMTDPNWEPVMKRASAIVTN
RGGRTCHAAIIARELGVPAVVGCGDATDVLKDGALVTVSCAEGDEGKIYDGLLETEVSEVQRGELPSVPV
KIMMNVGNPQLAFDFSQLPNAGVGLARLEFIINNNIGVHPKAILEYPNVDADLKKAVESVARGHASPRAF
YVDKLTEGIATIAAAFYPKPVIVRLSDFKSNEYKKLIGGSRYEPDEENPMLGFRGASRYIAEDFAQAFEM
ECMALKRVRDEMGLTNVEIMVPFVRTVKQAERVVGLLGKFGLKRGDNGLRLIMMCEVPSNAILAEEFLQH
FDGFSIGSNDLTQLTLGLDRDSGMELLAVDFDERDPAVKFMLKRAIDTCRKLDKYVGICGQGPSDHPDFA
KWLADEGIASISLNPDTVIETWQALAAKQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ppsA mutant is attenuated in mice (Cuccui et al., 2007).
COG COG0574G, under G: Carbohydrate transport and metabolism
References
Cuccui et al., 2007: Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PC, Titball RW, Wren BW. Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infection and immunity. 2007; 75(3); 1186-1195. [PubMed: 17189432].