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tox

Victor ID 3366
Gene Name tox
Sequence Strain (Species/Organism) Corynebacterium diphtheriae NCTC 13129
NCBI Gene ID 2650491
NCBI Protein GI 38232848
Locus Tag DIP0222
Genbank Accession BX248354
Protein Accession NP_938615
Other Database IDs UniProtKB-ID: Q6NK15_CORDI
UniRef100: UniRef100_P00587
UniRef90: UniRef90_P00588
UniRef50: UniRef50_P00588
UniParc: UPI000012994E
EMBL: BX248354
EMBL-CDS: CAE48728.1
RefSeq_NT: NC_002935.2
GenomeReviews: BX248353_GR
KEGG: cdi:DIP0222
NMPDR: fig|257309.1.peg.206
BioCyc: CDIP257309:DIP0222-MONOMER
Taxonomy ID 257309
Gene Starting Position 188978
Gene Ending Position 190660
Gene Strand (Orientation) +
Protein Name diphtheria toxin precursor
Protein pI 6.56
Protein Weight 56250.61
Protein Length 560
Protein Note Identical to previously sequenced Corynephage beta diphtheria toxin precursor SW:DTX_CORBE (P00588) (567 aa) fasta scores: E(): 6.2e-216, 100% id in 560 aa, and to Corynephage omega diphtheria toxin precursor SW:DTX_COROM (P00587) (560 aa) fasta scores: E(): 1.1e-215, 99.82% id in 560 aa. Note: The start codon for DIP0222 is 7 residues downstream of the one in Corynephage beta
DNA Sequence 
>gi|38232642:188978-190660 Corynebacterium diphtheriae NCTC 13129, complete genome
TGTGAGCAGAAAACTGTTTGCGTCAATCTTAATAGGGGCGCTACTGGGGATAGGGGCCCCACCTTCAGCC
CATGCAGGCGCTGATGATGTTGTTGATTCTTCTAAATCTTTTGTGATGGAAAACTTTTCTTCGTACCACG
GGACTAAACCTGGTTATGTAGATTCCATTCAAAAAGGTATACAAAAGCCAAAATCTGGTACACAAGGAAA
TTATGACGATGATTGGAAAGGGTTTTATAGTACCGACAATAAATACGACGCTGCGGGATACTCTGTAGAT
AATGAAAACCCGCTCTCTGGAAAAGCTGGAGGCGTGGTCAAAGTGACGTATCCAGGACTGACGAAGGTTC
TCGCACTAAAAGTGGATAATGCCGAAACTATTAAGAAAGAGTTAGGTTTAAGTCTCACTGAACCGTTGAT
GGAGCAAGTCGGAACGGAAGAGTTTATCAAAAGGTTCGGTGATGGTGCTTCGCGTGTAGTGCTCAGCCTT
CCCTTCGCTGAGGGGAGTTCTAGCGTTGAATATATTAATAACTGGGAACAGGCGAAAGCGTTAAGCGTAG
AACTTGAGATTAATTTTGAAACCCGTGGAAAACGTGGCCAAGATGCGATGTATGAGTATATGGCTCAAGC
CTGTGCAGGAAATCGTGTCAGGCGATCAGTAGGTAGCTCATTGTCATGCATAAATCTTGATTGGGATGTC
ATAAGGGATAAAACTAAGACAAAGATAGAGTCTTTGAAAGAGCATGGCCCTATCAAAAATAAAATGAGCG
AAAGTCCCAATAAAACAGTATCTGAGGAAAAAGCTAAACAATACCTAGAAGAATTTCATCAAACGGCATT
AGAGCATCCTGAATTGTCAGAACTTAAAACCGTTACTGGGACCAATCCTGTATTCGCTGGGGCTAACTAT
GCGGCGTGGGCAGTAAACGTTGCGCAAGTTATCGATAGCGAAACAGCTGATAATTTGGAAAAGACAACTG
CTGCTCTTTCGATACTTCCTGGTATCGGTAGCGTAATGGGCATTGCAGACGGTGCCGTTCACCACAATAC
AGAAGAGATAGTGGCACAATCAATAGCTTTATCGTCTTTAATGGTTGCTCAAGCTATTCCATTGGTAGGA
GAGCTAGTTGATATTGGTTTCGCTGCATATAATTTTGTAGAGAGTATTATCAATTTATTTCAAGTAGTTC
ATAATTCGTATAATCGTCCCGCGTATTCTCCGGGGCATAAAACACAACCATTTCTTCATGACGGGTATGC
TGTCAGTTGGAACACTGTTGAAGATTCGATAATCCGAACTGGTTTTCAAGGGGAGAGTGGGCACGACATA
AAAATTACTGCTGAAAATACCCCGCTTCCAATCGCGGGTGTCCTACTACCGACTATTCCTGGAAAGCTGG
ACGTTAATAAGTCCAAGACTCATATTTCCGTAAATGGTCGGAAAATAAGGATGCGTTGCAGAGCTATAGA
CGGTGATGTAACTTTTTGTCGCCCTAAATCTCCTGTTTATGTTGGTAATGGTGTGCATGCGAATCTTCAC
GTGGCATTTCACAGAAGCAGCTCGGAGAAAATTCATTCTAATGAAATTTCGTCGGATTCCATAGGCGTTC
TTGGGTACCAGAAAACAGTAGATCACACCAAGGTTAATTCTAAGCTATCGCTATTTTTTGAAATCAAAAG
CTG
Protein Sequence 
>gi|38232848|ref|NP_938615.1| diphtheria toxin precursor [Corynebacterium diphtheriae NCTC 13129]
MSRKLFASILIGALLGIGAPPSAHAGADDVVDSSKSFVMENFSSYHGTKPGYVDSIQKGIQKPKSGTQGN
YDDDWKGFYSTDNKYDAAGYSVDNENPLSGKAGGVVKVTYPGLTKVLALKVDNAETIKKELGLSLTEPLM
EQVGTEEFIKRFGDGASRVVLSLPFAEGSSSVEYINNWEQAKALSVELEINFETRGKRGQDAMYEYMAQA
CAGNRVRRSVGSSLSCINLDWDVIRDKTKTKIESLKEHGPIKNKMSESPNKTVSEEKAKQYLEEFHQTAL
EHPELSELKTVTGTNPVFAGANYAAWAVNVAQVIDSETADNLEKTTAALSILPGIGSVMGIADGAVHHNT
EEIVAQSIALSSLMVAQAIPLVGELVDIGFAAYNFVESIINLFQVVHNSYNRPAYSPGHKTQPFLHDGYA
VSWNTVEDSIIRTGFQGESGHDIKITAENTPLPIAGVLLPTIPGKLDVNKSKTHISVNGRKIRMRCRAID
GDVTFCRPKSPVYVGNGVHANLHVAFHRSSSEKIHSNEISSDSIGVLGYQKTVDHTKVNSKLSLFFEIKS
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: at saturating toxin concentrations, DT causes a complete cessation of protein synthesis in HeLa cells after a lag period of ~1.5 h (Collier, 2001).
References
Collier, 2001: Collier RJ. Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. Toxicon : official journal of the International Society on Toxinology. 2001; 39(11); 1793-1803. [PubMed: 11595641].