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DIP2010

Victor ID 3364
Gene Name DIP2010
Sequence Strain (Species/Organism) Corynebacterium diphtheriae NCTC 13129
NCBI Gene ID 2650114
NCBI Protein GI 38234574
Locus Tag DIP2010
Genbank Accession BX248359
Protein Accession NP_940341
Other Database IDs UniProtKB-ID: Q6NF84_CORDI
UniRef100: UniRef100_Q6NF84
UniRef90: UniRef90_Q6NF84
UniRef50: UniRef50_Q6NF84
UniParc: UPI0000213BFA
EMBL: BX248359
EMBL-CDS: CAE50541.1
RefSeq_NT: NC_002935.2
GenomeReviews: BX248353_GR
KEGG: cdi:DIP2010
NMPDR: fig|257309.1.peg.1932
BioCyc: CDIP257309:DIP2010-MONOMER
Taxonomy ID 257309
Gene Starting Position 2059671
Gene Ending Position 2065289
Gene Strand (Orientation) -
Protein Name putative surface-anchored membrane protein
Protein pI 4.99
Protein Weight 189830.43
Protein Length 1872
Protein Note Similar to Actinomyces viscosus putative usher-like protein precursor TR:Q9AJ93 (EMBL: AF106034) (1411 aa) fasta scores: E(): 0.034, 22.657% id in 843 aa, and to Actinomyces naeslundii putative fimbrial associated protein TR:O05995 (EMBL: U85708) (375 aa) fasta scores: E(): 0.14, 25.131% id in 191 aa. Note: Contains a potential sortase anchor site (LPLTG) upstream of the C-terminal region transmembrane domain
DNA Sequence 
>gi|38232642:2059671-2065289 Corynebacterium diphtheriae NCTC 13129, complete genome
CCTAACGCTTACGACGCGCCACTAACCACAATGCTGCAGCCACCAACAGGCCCGCAGCACCGGCCAACAG
CCACCGCAAGTAACCATTCGAACCAGTCAACGGCAGTGTGGATGCCGACACATTAGCCACCTTGATCAAC
CACGGCTTACCCTGCGGGTGCTCCACCGTGATCAACCCCGAATCAGCATCATAGTTATCCAAGGTCACCT
CAAGATCACCTATCGCACCCGCATTCGCAGCCTTGACATCAAAACGCCACGGCTTAGGCAGCAACTGCCC
ACCCTGAGGAGCCTGAGTCTCCACCAACTCGTAACTACCAGGGCGCAAGCGCACTGCAAACAACGCCTGC
TCCACCGACTTCGCCGACTTCGCCGGCGCATCCGCAACCTCAGGCAACTCTTTACGCTGGCCATTCTCCC
CTATCCCATAGATGGCGAAGTGCGCGCCGGGCAGCGGAGAGTTATCGGCGTTCACCTTGGCAATGTTGAT
CTCAGCGTCAGTGGTGTACACGTTGTTGATCACCACGGTGTGCGAGTGGGCGTCGTTAAGCTCAATGCCT
GATTCTGGCATCTGGAGGCGAGGCTCCGTGCCGTTATAAATCGGACGGTCTGTCAACGGCGGAATCACTG
GCGCACTAGCAGCTCCTGCACGCTCCGTGGGGAACAAGTAGGTAGGCACCATGCGCAGCGCATTGTTTTC
CAACTTGGTGCGCAAGGCGGGGTCGTCTTCTTCCTTGATCGTGCAGGACGTACCAATAGGGACTTCAGGA
GATCGCCATGTCTCACCTTCTCGAATCTTAATGACGCCACGTGCAACCTTGTTTCCTACTTCTTGCGACA
TAGGATTGGGTTGATTTGGGAATAGATGCGGCATGGTGCAGGTGTAGGAGAATTCAAATGTTTCTTCTGG
AGCAATCACAGCATGGCCGGGGTCGCCCTCAACATATTTTTGTAGGCTCAAAATTCGTTGAGGCATCACG
TATGAATTGGTGAATTCAATTCGTGTTGGTTCAGATTCCGACAAAACAACATCTTTAATTTCTGGGGTGA
AATAGGAGCGCTTTTCATGTTCCCCAGCGAATTCAGCAACTTTATTCGTTTCATCCACTACGCCTTTTAC
CTCTCCTGGTAAATGCCCTTCGGTGTTTTCACTGAAAGTACATACTGCCGACGCAGGAATTTTTACGTGA
GCCGTAGGATCAGCGAAAATTGGCGTTGGTTTTTCTGCATCAGCTTGTATATCTACGTCGTTTGAATAGG
AACGATCCTTGATGTATGGATCGTCGCACTTATAAGTGATGCTGTATGTAGTGTTAAGCAACCAAGGATC
TACCGAGTGTTCTGGTTTTGCGATTGTCTTATGCACCATGACATCGGCGCGCGGACGAATGTAATCATTA
GTTACCTGAATTTTTTGAGTGCCATTATTTTCTTGTTTCTCCGTGACAAAACGAGCCGAGGCGGAGTTTG
ATGATGTGCGTTGCACAGCCGTATTTTCCACCACTGCCGGACCACTGAATTGGGTCGTCGCTTTGGCATC
ATAAAGTGCAATCGGGTTTTCGGTCACAGTGCAGTTATACCCAACAGGAACCTCAACGCTATCGTGCCGT
TCGTCTGCAACTTGGTACGACGCTCGGCTTTGGCCTTTAGCATTTAATGCAACTGTAATTGTGGGGTCTG
GAATGGAATGCTTATCTGCCAAATCACTTCCTGCAAAACGAGGATCAGTACATTTCAAGGTGAAGGCAAA
GTTATCTTTACCAGCAAGTTCTGGACCATCATTCGTCAACACCTTGTTGATCTCTACCTTTGTTTTATCG
TAAGTGTAGGTGTTCCATACGATAAAGGTTCCTTGGAAATTCTCTTTCTCATTTCCAGCAATAACCACTG
TGGTTGCAAACTCATTTTTTGGATCCACTTCGCACGCTGCATGATTTTCGCATGCTGCTTCGGTATCGCC
CCAGCCATTCGTGCTGTCTGTATGAGTCCAACGAGCTGTCACTTGTGCGTTTGGCTCTTGGGCTTTCTCA
GAGTCCTCAATAATCTCACATGATGCACCCACGGGAATGTCTTTAACAGAATGCGATTCGGCACTATCAA
AACGTCCCAGCGTAATGGTGCCGTTTTTCTTCCAGTCGCCTAAGGTACAACGATACGAAATTTCAAAGCG
TCGATCCTCATGGATGGTAGATACTCCTTCACCATCGACTTTCTTTTTAAGGTTAAATGAGCCAGTCTTC
AACGTGAAAGTATTAGTAGCATCTAGTCGGTTATGATCCGAGTTTATCGCTACCGATGCCTTATCATTCG
TTTTTGTTCCGTGAACGAAGAACTCAACGTGAGATAACGTTGCATTAGACAACTCCACTGAAGAGGAATC
TTCTTCAACCGTACAAATAGATCCCCGTGGCACCTTAGTGGCACCAGTGTTAATCGCATCGGCGCTTAAG
GTATTTTCTGCAACTACTTGACCATTGATTTCACAACGGTATCGGAATAGGAAGGGTTGTTCTGGACGGA
CAACTGCATTTTTTAGTTCCGAGTTAACGTCATTTCCAACTTGGTCAATGACCCGAACACGTTTGGTAAG
TTCCAAAGATACAGCATCGGTTTCGTAATGGTTTTCCAATCGAATTGCGTTACTACCATTAGGGTTAATC
GTGATGTCCGTAGAATCTGCAACTTCAAGCAGCTCGCCTTTAATCCAGTGCTTGTGATGGGTAGCCCCAG
TTATAGGAGTTACTTCCTCACTTAATGTGCAGCTTTCACCTGCAACAACCCCAGGTACGGCTTTCTGCTC
ATCTTTTTGCAAAGTGATGGAATGATTACCGGTGATTGAGCATGCGACGTTGACTGTAAAACTCGATGGA
ATCTGGTCTACTAATGCTTGAGGCATATCACCATCGAGTACTTTTTTGGTTACTTTTAGCTCGCCACGTG
CATTTTCAAACGTATTCGTCAGCACCTTATTTATAGGAGTGGAGTCCTCAATTGTCACCTCTGGACCATC
CGCGAATTTATAACTCATTTCGGTTCCGGCAGGGGCTTCGGTGAGCTCGCTAAAGCTACAAGTAGTTCCC
ACTGGAAAGTTTCCAAATTCAACAGTTTGATTATCACTTACTGTTTTTAGAACTTTTCGAGGCGTTTCTA
CACCAGGAACCGTACATTCTGCCACCACACTGTATGTTAATGCATCGATTGATGCAGAAATTTCAGGAGA
AAATGTGTCTTTTTTATGAACTTTTTTCTGTATTGAAATAGGAGCTACCTGACGTTTTGCGGTGTTATCT
ACAACCACTTTGACAATGTCGCCGGCAGTTGAAGCACGAAGATGGAACGGCGCGGGGACCACAAAATCCA
CGCCTTTTTGTTCAGGCTGTTTTTCGCTCAACGTACAATTGGCATCGACAGGAATGTTTTCGATGACTTG
CCGTCCGTCCTTCTTCACCACGATATTGTCTTGCGAATAGACTTCTACTCCGGAATCTTCACATCGAAGA
TTGAATGAAAACTCGTGTGAATTCGTGAGATCAGAGGCATCGCCGCTCACCGTCTTTTCGATCTCCACGC
TCGCAAGCTCACGCGTGTATGTATTTTCTACGTTGAGCGAATATTGACCTGGTTTGGGAATCCATACTGA
GTTAGTAGAACAATCTTGAGAATTATTATCGATAGTGTTTCCAAAACAGATGTTGGAATTCCACTCAGTT
TTCAAACTAAAACCAGGAATTTTAGCGTCTGCTTGAACATTCGGATCGAGTCGTGCAGTTTCTTCAAAAC
TGCACTGTGTTCCCACTGGAAAAGGTCCGATTTCTATACTTCCATCACGAGGAACGACAACGGTTTTAGA
GTCTACAAAATACGGATTGGTTTCTGGGAGCCCACCATGTTCGGGGCGAGCATTAGGATGTGGTACGTAA
CGACAGGTGTAAGTGACAGGAAACTTCTCGGGCAGTTTTGTTGCTGGAATTTTGTCACGGTTAATGATGG
TCTTGGTCAGCTTAATAGTGGCTGTTTGAGCCTCATAGTTATTTTCTGCTGTAGCTAGAACTGTTTTCTT
GTTTTTAAACGCATCGGTGTCGGCTTTAAAGCGGTATGTACCGTTATCCTGATTAGCATCTGCAGTGGTG
TTTTCACTGCTCCAAGTGGTGGAAAGCTTCATCCGAGAATCGTCGACTTTGGGGGTAACTTCCTTGATTT
CGCACTGAGTTCCAACAGCAACTTTTCCGATTTCTTTGGATTCTCCGTTGTGGACGCCCTTAATTTCTCC
CTTGATTTCTTTTTCATTAGCTCCTTTTTCACAGCTATAGGTGAAATCAAAGGTTTGATTGTTGAGCTCT
TCTAAAAGTTGTGGCGTATTTACGTTTACTTTTTTCGAAACCGAGACTGGTACAACTGGCAGATTGTTAA
AACCGCAAGAAATCAAGCTTTTGGTGTCTGCAGTCAAAGTAATTGAAGTATCGCTAGTTTTGATCGGAAT
ATCAGTAGGTGCTTGCCCATAGGAGTAGCGCTGGCAGCGTGCGTTTTTAAACCGGAAGTTTTGTTTTTGA
TCTCCGGTAGGTCGCTCAGTGATAGTGATCTTAAAGGATTCCTTATTAATCGACTTCATAGCAAAGGTGT
CTTGGCCATTTTTATCTGTCTCGATCGACGGAGGAATGCCTTGCACACCAGCCGCTGTAATATCGAAATT
CCAGCCAGCTGGATTTTCTATCACGTTTCCGTCTGCATCAATAATGTTTTTAGCGATTTGGAAACATCCG
GTAAAAATCTGTTGTCCCATTCGCTGCGGCAATGTGGAATAGTCGGGCAAAATAATTGGCTCTAGGCCCG
GTGAGGTTATCTTCTCCAGCATTTGTTTGCCGGTCAGGGAACGATCTATTTTCCATGGATAACGCGACCA
ATAGTAATCGTCTTCGGAAGGAAGAATCGGTTTATAGAGATCAAACGGCTTATCATCAGAAAGCTGGCCA
ATACCCACCGGAATAAGTTTTGCGCCTTTATCAGAAATAAGTTTGGCTTGGGTAACGGCATTTTCTAATT
CCACAACCTCGGTGGTGGTTCCCAACCAATTTCTCCCATTGTTATCCCAAGTTGGTTGACCATCAGTGAT
GAAGTAAACGGCGTCATACTTGATGCCTCTGTCTATGTCATTCGCGATTGCTTGGAGCCCGCCCTCCCAG
TTGGTACCACCGTTGGGAGAACCCTTTTTGTTCTCTCGGATCGCTGGCATCTGGATGTCATTGATAGCGG
CAACAACTTTGTTGTATCCGTCATCATTAGCAAGACTTACTGGCGTGAAATTTTTGTTTCCAGCAGCAGG
CGAGTGTGAAGCAAAGGTATAAATACCAAAACGATAGGGAGATCCTTTCAAGCTCTTGACCAGCTCCAAC
GCTGCTTGCTTAGATTTTTCCACGTCCGAAGCGCTCAGGGAATTGGACAAGTCAAAGGAAATCGCAACAG
AACCGCCACAGGTTTCAAACTCTTTTTTCGGCAGTGGCTCCGCATTCGCTGATGGCGCTGCAATTAACGG
CACAAGAACAATGCTCATGACCATTGCGAGGATGGCGACGAGTGCTGCGGGGATAGACGCTCGTTTCTTG
ATGGTGCGTAGGTTACTCA
Protein Sequence 
>gi|38234574|ref|NP_940341.1| putative surface-anchored membrane protein [Corynebacterium diphtheriae NCTC 13129]
MSNLRTIKKRASIPAALVAILAMVMSIVLVPLIAAPSANAEPLPKKEFETCGGSVAISFDLSNSLSASDV
EKSKQAALELVKSLKGSPYRFGIYTFASHSPAAGNKNFTPVSLANDDGYNKVVAAINDIQMPAIRENKKG
SPNGGTNWEGGLQAIANDIDRGIKYDAVYFITDGQPTWDNNGRNWLGTTTEVVELENAVTQAKLISDKGA
KLIPVGIGQLSDDKPFDLYKPILPSEDDYYWSRYPWKIDRSLTGKQMLEKITSPGLEPIILPDYSTLPQR
MGQQIFTGCFQIAKNIIDADGNVIENPAGWNFDITAAGVQGIPPSIETDKNGQDTFAMKSINKESFKITI
TERPTGDQKQNFRFKNARCQRYSYGQAPTDIPIKTSDTSITLTADTKSLISCGFNNLPVVPVSVSKKVNV
NTPQLLEELNNQTFDFTYSCEKGANEKEIKGEIKGVHNGESKEIGKVAVGTQCEIKEVTPKVDDSRMKLS
TTWSSENTTADANQDNGTYRFKADTDAFKNKKTVLATAENNYEAQTATIKLTKTIINRDKIPATKLPEKF
PVTYTCRYVPHPNARPEHGGLPETNPYFVDSKTVVVPRDGSIEIGPFPVGTQCSFEETARLDPNVQADAK
IPGFSLKTEWNSNICFGNTIDNNSQDCSTNSVWIPKPGQYSLNVENTYTRELASVEIEKTVSGDASDLTN
SHEFSFNLRCEDSGVEVYSQDNIVVKKDGRQVIENIPVDANCTLSEKQPEQKGVDFVVPAPFHLRASTAG
DIVKVVVDNTAKRQVAPISIQKKVHKKDTFSPEISASIDALTYSVVAECTVPGVETPRKVLKTVSDNQTV
EFGNFPVGTTCSFSELTEAPAGTEMSYKFADGPEVTIEDSTPINKVLTNTFENARGELKVTKKVLDGDMP
QALVDQIPSSFTVNVACSITGNHSITLQKDEQKAVPGVVAGESCTLSEEVTPITGATHHKHWIKGELLEV
ADSTDITINPNGSNAIRLENHYETDAVSLELTKRVRVIDQVGNDVNSELKNAVVRPEQPFLFRYRCEING
QVVAENTLSADAINTGATKVPRGSICTVEEDSSSVELSNATLSHVEFFVHGTKTNDKASVAINSDHNRLD
ATNTFTLKTGSFNLKKKVDGEGVSTIHEDRRFEISYRCTLGDWKKNGTITLGRFDSAESHSVKDIPVGAS
CEIIEDSEKAQEPNAQVTARWTHTDSTNGWGDTEAACENHAACEVDPKNEFATTVVIAGNEKENFQGTFI
VWNTYTYDKTKVEINKVLTNDGPELAGKDNFAFTLKCTDPRFAGSDLADKHSIPDPTITVALNAKGQSRA
SYQVADERHDSVEVPVGYNCTVTENPIALYDAKATTQFSGPAVVENTAVQRTSSNSASARFVTEKQENNG
TQKIQVTNDYIRPRADVMVHKTIAKPEHSVDPWLLNTTYSITYKCDDPYIKDRSYSNDVDIQADAEKPTP
IFADPTAHVKIPASAVCTFSENTEGHLPGEVKGVVDETNKVAEFAGEHEKRSYFTPEIKDVVLSESEPTR
IEFTNSYVMPQRILSLQKYVEGDPGHAVIAPEETFEFSYTCTMPHLFPNQPNPMSQEVGNKVARGVIKIR
EGETWRSPEVPIGTSCTIKEEDDPALRTKLENNALRMVPTYLFPTERAGAASAPVIPPLTDRPIYNGTEP
RLQMPESGIELNDAHSHTVVINNVYTTDAEINIAKVNADNSPLPGAHFAIYGIGENGQRKELPEVADAPA
KSAKSVEQALFAVRLRPGSYELVETQAPQGGQLLPKPWRFDVKAANAGAIGDLEVTLDNYDADSGLITVE
HPQGKPWLIKVANVSASTLPLTGSNGYLRWLLAGAAGLLVAAALWLVARRKR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spaC (DIP2010) mutant has diminished adherence to human pharyngeal epithelial cells (Mandlik et al., 2007).
References
Mandlik et al., 2007: Mandlik A, Swierczynski A, Das A, Ton-That H. Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells. Molecular microbiology. 2007; 64(1); 111-124. [PubMed: 17376076].