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ipaC from Shigella flexneri 5a

Victor ID 31
Gene Name ipaC from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876448
NCBI Protein GI 13449073
Locus Tag pWR501_p134
Protein Accession NP_085289.1
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 103161
Gene Ending Position 104309
Gene Strand (Orientation) -
Protein Name invasion protein
DNA Sequence 
>gi|13448939:103161-104309 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
ATTAAGCTCGAATGTTACCAGCAATCTGACTGGCTGCCGAATTCTTTGATTGGTTGATGCTGTCAATTAT
ATTCAATAATTTTTGTATTAATTGATTTGTCGCTTGGGATGCTTCTTTAGATACTTGGGATGCTTCCTCT
GCTTGTTTACTGCTGGCCTGACTGATTAGTTGTTCTTCTTCTTCAAGAGCAGATGCATAACGCCCTCCTG
ATGTGGATATATTACCAGCAACGGCTGATGTTTCCATTGTTGCACGGCCAATGTTTTGTTTTTGCTGCGC
AGAAAGGGTATTGAGCTCGTAAGTTCTTCTCTGGGTGTCAATTTTATCCTGCAAAGAAATATCGGGAGAA
CTAAGAGAAGTTTTATGTTCAGTTGACAGGGATATATTATCTGGCGCCAGTTTATTTTTACCTAAAAATT
TTGTGCTAGAGTTAGTTTGTGGTGAGGTGATATTTGTATCTATTTGTTTATTTAACCCTAATTTAGAACC
TGCAAGCTCTTTTTCAAGAGATTGAGCAGTGGCAAGGTTCTTTCTTAAGGCTCCTTTTTGGTCGCTAATC
CCTGAATGCGTTTTTTTGGCACCGATACCCGTTATACCTACTTGTGTGACTGCTCCAGTAATGCTTGATG
ATAGGGCTGCCAGGCCTTGCCGAACAATGTTCTCTGCAGCTGATTTTGTAGCATCGAACGCAATCAATGA
CAATTGAGAGCCCAATTTAGTTTCTGCAGTGCGGAGAGCAGAAAGTAGAACGGCTACACTAATAATTAAA
GAAACAGCATTAGAAGAAAGACTGGAAATATCCAGAGTGTTCTCTGGAGTAAGGGTGTGACTCATCTCTG
AAAGATCTTTCATCTTTTTGTCAGTAAGGCGAGCAATGATTTCTGAATCATGCTGAACCTGCTCTGATAA
CTTTAAAAGTTGATCATCATTTAATGTGGTTGTTAATACGGGATTTTTACCGACATTAAGTGGAATATGC
GCTGCAATCTGCTGATAATTTTGTGATTTTTGTGTTTCGGAAGAACTTTGAGTTTGTTTTGTGGATATAT
CTGTATATAAAGTCTGGGTTGGTTTTGTGTTTTGAATTTCCATAACATTCTCCTTATTTGTATCAAGCAG
TAGTTTGTTGCAAAATTGCTTTTGCAACA
Protein Sequence 
>gi|13449073|ref|NP_085289.1| invasion protein [Shigella flexneri 5a str. M90T] MLQKQFCNKLLLDTNKENVMEIQNTKPTQTLYTDISTKQTQSSSETQKSQNYQQIAAHIPLNVGKNPVLTTTLNDDQLLKLSEQVQHDSEIIARLTDKKMKDLSEMSHTLTPENTLDISSLSSNAVSLIISVAVLLSALRTAETKLGSQLSLIAFDATKSAAENIVRQGLAALSSSITGAVTQVGITGIGAKKTHSGISDQKGALRKNLATAQSLEKELAGSKLGLNKQIDTNITSPQTNSSTKFLGKNKLAPDNISLSTEHKTSLSSPDISLQDKIDTQRRTYELNTLSAQQKQNIGRATMETSAVAGNISTSGGRYASALEEEEQLISQASSKQAEEASQVSKEASQATNQLIQKLLNIIDSINQSKNSAASQIAGNIRA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaC mutants cannot invade cultured cells or lyse red blood cells (Terry et al., 2008).
References
Terry et al., 2008: Terry CM, Picking WL, Birket SE, Flentie K, Hoffman BM, Barker JR, Picking WD. The C-terminus of IpaC is required for effector activities related to Shigella invasion of host cells. Microbial pathogenesis. 2008; 45(4); 282-289. [PubMed: 18656530].