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ipaD from Shigella flexneri 5a

Victor ID 29
Gene Name ipaD from Shigella flexneri 5a
Sequence Strain (Species/Organism) Shigella flexneri 5a
NCBI Gene ID 876444
NCBI Protein GI 13449072
Locus Tag pWR501_p133
Protein Accession NP_085288.1
Other Database IDs UniProtKB-ID: IPAD_SHIFL
UniRef100: UniRef100_P18013
UniRef90: UniRef90_Q03947
UniRef50: UniRef50_Q03947
UniParc: UPI000012D7D6
EMBL: J04117
EMBL: X15319
EMBL: AL391753
EMBL: AF348706
EMBL: AY206439
EMBL: AF386526
EMBL: M34849
EMBL-CDS: AAA26524.1
EMBL-CDS: CAA33383.1
EMBL-CDS: CAC05801.1
EMBL-CDS: AAK18444.1
EMBL-CDS: AAP78989.1
EMBL-CDS: AAL72350.1
EMBL-CDS: AAA98426.1
RefSeq_NT: NC_002698.1
RefSeq_NT: NC_004851.1
PDB: 2J0N
PDB: 2J0O
PDB: 2JAA
TCDB: 1.C.36.3.1
EnsemblGenome: EBESCG00000093166
Taxonomy ID 623
Plasmid No pWR501
Gene Starting Position 102112
Gene Ending Position 103110
Gene Strand (Orientation) -
Protein Name invasion protein
DNA Sequence 
>gi|13448939:102112-103110 Shigella flexneri 5a virulence plasmid pWR501, complete sequence
CTCAGAAATGGAGAAAAAGTTTATCTGTATCTGTACATGAGCTTATTGTACTACTCAAAACCTTTACTAA
ATTATCAAAAATACTATTGGCATTACTGTATTTTTGAACTAAAGTTTGAAGATTATTTTTCATTGTTTCA
TCTTCGGCAGAGAATCCGGCATTCCATGCCTGATATTTTGCATTATCTAGCACAACCTCGCCATTTCCAC
CTAGATTATCTAAGCTTTTTAACATATTGTCTATTGGGGTCATGTTTATACTGACAACATATCCCCCGTT
TTTTTGAGATACCTTGCCGATTGTTCCACCTAATTCTGTAAGCCATTTATTTGCTTGTTCCTGACTAACA
GTATTATTTGCTGGATATAGCGGTTTATCTTTATATTTTTCCTTGAGTTCTTCCAATGCCTTTTTAAGCG
AGTTGACTTGTAATTTCACGGAGTTTCCGTCGTTACCTCCGGGAGAGATCCAGCCGGCAAGACTGGAAAG
AACAGCGCTAAAATCTTGATACATTTGAGTATATGAACTAACGGCATGTTCATATACTTTCAGATACTGT
TCATTAATATCATTGATGGAGTTTGCAATTTTAGCCCACAGTTCTCTATGAGATATCATTTGATCTCCAT
CAAGCTCGGCTTCTTTCGGGGCTGAATGTAATAATTCTCTTGCGTCTTTATTAATTGGATATTCGTTCCT
GGAAAGAATATCCAATAGTTGAGCGGATTTATTTACATCCATGCTAATCTGAGATGAATGTAATGCTATT
TCTTCTAGCGATGTTTTAGTCAACGTTTTTTGTGAAAGCTCTTTCTTTAATGCCTGATTTGTTGTTCTGA
TATTATGAAGGGTGTCGTTGAGCATAGTAAGGGAACTTACAGGATGAGAACTGGTCGTTGTTTTTATATC
AGAATTAACTGTTTCGGTTGATGAACCGTTGGTATTGTTTGGACTGAATGATGAGGTGGAAATACTATTA
GTCAGAGTTGTTATATTCA
Protein Sequence 
>gi|13449072|ref|NP_085288.1| invasion protein [Shigella flexneri 5a str. M90T] MNITTLTNSISTSSFSPNNTNGSSTETVNSDIKTTTSSHPVSSLTMLNDTLHNIRTTNQALKKELSQKTLTKTSLEEIALHSSQISMDVNKSAQLLDILSRNEYPINKDARELLHSAPKEAELDGDQMISHRELWAKIANSINDINEQYLKVYEHAVSSYTQMYQDFSAVLSSLAGWISPGGNDGNSVKLQVNSLKKALEELKEKYKDKPLYPANNTVSQEQANKWLTELGGTIGKVSQKNGGYVVSINMTPIDNMLKSLDNLGGNGEVVLDNAKYQAWNAGFSAEDETMKNNLQTLVQKYSNANSIFDNLVKVLSSTISSCTDTDKLFLHF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ipaD mutants are completely unable to invade cultured cells or lyse RBCs (Picking et al., 2005) .
References
Picking et al., 2005: Picking WL, Nishioka H, Hearn PD, Baxter MA, Harrington AT, Blocker A, Picking WD. IpaD of Shigella flexneri is independently required for regulation of Ipa protein secretion and efficient insertion of IpaB and IpaC into host membranes. Infection and immunity. 2005; 73(3); 1432-1440. [PubMed: 15731041].