Victors

HTNVsMgp1
Victor ID	2877
Gene Name	HTNVsMgp1
Sequence Strain (Species/Organism)	Hantavirus
NCBI Gene ID	2943079
NCBI Protein GI	38371714
Locus Tag	HTNVsMgp1
Protein Accession	NP_941987.1
Other Database IDs	UniProtKB-ID: GP_HANTV UniRef100: UniRef100_P08668 UniRef90: UniRef90_P16853 UniRef50: UniRef50_P21400 UniParc: UPI0000138737 EMBL: M14627 EMBL: Y00386 EMBL-CDS: AAA43836.1 EMBL-CDS: CAA68456.1 RefSeq_NT: NC_005219.1
Taxonomy ID	11599
Segment No	segment M
Gene Starting Position	40
Gene Ending Position	3447
Gene Strand (Orientation)	+
Protein Name	precursor structural polyprotein
DNA Sequence	>gi\|38371712:40-3447 Hantaan virus, complete genome CATGGGGATATGGAAGTGGCTAGTGATGGCCAGTTTAGTATGGCCTGTTTTGACACTGAGAAATGTCTAT GACATGAAAATTGAGTGCCCCCATACAGTAAGTTTTGGGGAAAACAGTGTGATAGGTTATGTAGAATTAC CCCCCGTGCCATTGGCCGACACAGCACAGATGGTGCCTGAGAGTTCTTGTAACATGGATAATCACCAATC GTTGAATACAATAACAAAATATACCCAAGTAAGTTGGAGAGGAAAGGCTGATCAGTCACAGTCTAGTCAA AATTCATTTGAGACAGTGTCCACTGAAGTTGACTTGAAAGGAACATGTGTTCTAAAACACAAAATGGTGG AAGAATCATACCGTAGTAGGAAATCAGTAACCTGTTACGACCTGTCTTGCAATAGCACTTACTGCAAGCC AACACTATACATGATTGTACCAATTCATGCATGCAATATGATGAAAAGCTGTTTGATTGCATTGGGACCA TACAGAGTACAGGTGGTTTATGAGAGAAGTTACTGTATGACAGGAGTCCTGATTGAAGGGAAATGCTTTG TCCCAGATCAAAGTGTGGTCAGTATTATCAAGCATGGGATCTTTGATATTGCAAGTGTTCATATTGTATG TTTCTTTGTTGCAGTTAAAGGGAATACTTATAAAATTTTTGAACAGGTTAAGAAATCCTTTGAATCAACA TGCAATGATACAGAGAATAAAGTGCAAGGATATTATATTTGTATTGTAGGGGGAAACTCTGCACCAATAT ATGTTCCAACACTTGATGATTTCAGATCCATGGAAGCATTTACAGGAATCTTCAGATCACCACATGGGGA AGATCATGATCTGGCTGGAGAAGAAATTGCATCTTATTCTATAGTCGGACCTGCCAATGCAAAAGTTCCT CATAGTGCTAGCTCAGATACATTGAGCTTGATTGCCTATTCAGGTATACCATCTTATTCTTCCCTTAGCA TCCTAACAAGTTCAACAGAAGCTAAGCATGTATTCAGCCCTGGGTTGTTCCCAAAACTTAATCACACAAA TTGTGATAAAAGTGCCATACCACTCATATGGACTGGGATGATTGATTTACCTGGATACTACGAAGCTGTC CACCCTTGTACAGTTTTTTGCGTATTATCAGGTCCTGGGGCATCATGTGAAGCCTTTTCTGAAGGCGGGA TTTTCAACATAACCTCTCCCATGTGCTTAGTGTCAAAACAAAATCGATTCCGGTTAACAGAACAGCAAGT GAATTTTGTGTGTCAGCGAGTGGACATGGACATTGTTGTGTACTGCAACGGGCAGAGGAAAGTAATATTA ACAAAAACTCTAGTTATTGGACAGTGTATATATACTATAACAAGCTTATTCTCATTACTACCTGGAGTAG CACATTCTATTGCTGTTGAATTGTGTGTACCTGGGTTCCATGGTTGGGCCACAGCTGCTCTGCTTGTTAC ATTCTGTTTCGGATGGGTTCTTATACCAGCAATTACATTTATCATACTAACAGTCCTAAAGTTCATTGCT AATATTTTTCACACAAGTAATCAAGAGAATAGGCTAAAATCAGTACTTAGAAAGATAAAGGAAGAGTTTG AAAAAACAAAAGGCTCAATGGTATGTGATGTCTGCAAGTATGAGTGTGAAACCTATAAAGAATTAAAGGC ACACGGGGTATCATGCCCCCAATCTCAATGTCCTTACTGTTTTACTCATTGTGAACCCACAGAAGCAGCA TTCCAAGCTCATTACAAGGTATGCCAAGTTACTCACAGATTCAGGGATGATCTAAAGAAAACTGTTACTC CTCAAAATTTTACACCAGGATGTTACCGGACACTAAATTTATTTAGATACAAAAGCAGGTGCTACATCTT TACAATGTGGATATTTCTTCTTGTCTTAGAATCCATACTGTGGGCTGCAAGTGCATCAGAGACACCATTA ACTCCTGTCTGGAATGACAATGCCCATGGGGTAGGTTCTGTTCCTATGCATACAGATTTAGAGCTTGATT TCTCTTTAACATCCAGTTCCAAGTATACATACCGTAGGAAGTTAACAAACCCACTTGAGGAAGCACAATC CATTGACCTACATATTGAAATAGAAGAACAGACAATTGGTGTTGATGTGCATGCTCTAGGACACTGGTTT GATGGTCGTCTTAACCTTAAAACATCCTTTCACTGTTATGGTGCTTGTACAAAGTATGAATACCCTTGGC ATACTGCAAAGTGCCATTATGAAAGAGATTACCAATATGAGACGAGCTGGGGTTGTAATCCATCAGATTG TCCTGGGGTGGGCACAGGCTGTACAGCATGTGGTTTATACCTAGATCAACTGAAACCAGTTGGTAGTGCT TATAAAATTATCACAATAAGGTACAGCAGGAGAGTCTGTGTTCAGTTTGGGGAGGAAAACCTTTGTAAGA TAATAGACATGAATGATTGTTTTGTATCTAGGCATGTTAAGGTCTGCATAATTGGTACAGTATCTAAATT CTCTCAGGGTGATACCTTATTGTTTTTTGGACCGCTTGAAGGTGGTGGTCTAATATTTAAACACTGGTGT ACATCCACATGTCAATTTGGTGACCCAGGAGATATCATGAGTCCAAGAGACAAAGGTTTTTTATGCCCTG AGTTTCCAGGTAGTTTCAGGAAGAAATGCAACTTTGCTACTACCCCTATTTGTGAGTATGATGGAAATAT GGTCTCAGGTTACAAGAAAGTGATGGCGACAATTGATTCCTTCCAATCTTTTAATACAAGCACTATGCAC TTCACTGATGAAAGGATAGAGTGGAAAGACCCTGATGGAATGCTAAGGGACCATATAAACATTTTAGTAA CGAAGGACATTGACTTTGATAACCTTGGTGAAAATCCTTGCAAAATTGGCCTACAAACATCTTCTATTGA GGGGGCCTGGGGTTCTGGTGTGGGGTTCACATTAACATGTCTGGTATCACTAACAGAATGTCCTACCTTT TTGACCTCAATAAAGGCTTGTGATAAGGCTATCTGTTATGGTGCAGAGAGTGTAACATTGACAAGAGGAC AAAATACAGTCAAGGTATCAGGGAAAGGTGGCCATAGTGGTTCAACATTTAGGTGTTGCCATGGGGAGGA CTGTTCACAAATTGGACTCCATGCTGCTGCACCTCACCTTGACAAGGTAAATGGGATTTCTGAGATAGAA AATAGTAAAGTATATGATGATGGGGCACCGCAATGTGGGATAAAATGTTGGTTTGTTAAATCAGGGGAAT GGATTTCAGGGATATTCAGTGGTAATTGGATTGTACTCATTGTCCTCTGTGTATTTCTATTGTTCTCCTT GGTTTTACTAAGCATTCTCTGTCCCGTAAGGAAGCATAAAAAATCATA
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: Two Hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11E10), were used to examine the pathogenesis of Hantaan virus infection in a mouse model and identify virus factors relating to virulence. After subcutaneous inoculation of newborn BALB/c mice, cl-1 caused fatal disease with high viral multiplication in peripheral organs, but mu11E10 produced nonfatal infection with a low level of virus multiplication. Sequence comparison detected a single deduced amino acid change (cl-1 Ile to mu11E10 Thr) at amino acid number 515 in glycoprotein G1. In mouse brain microvascular endothelial cells in vitro, viruses possessing a cl-1-derived M segment grew more rapidly than viruses containing a mu11E10-derived M segment. These results suggest that the single amino acid change in the glycoprotein alters peripheral growth, which affects invasion of the central nervous system in mice (Ebihara et al., 2000).
References	*Ebihara et al., 2000:* Ebihara H, Yoshimatsu K, Ogino M, Araki K, Ami Y, Kariwa H, Takashima I, Li D, Arikawa J. Pathogenicity of Hantaan virus in newborn mice: genetic reassortant study demonstrating that a single amino acid change in glycoprotein G1 is related to virulence. Journal of virology. 2000; 74(19); 9245-9255. [PubMed: 10982372].


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HTNVsMgp1