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colT

Victor ID 2824
Gene Name colT
Sequence Strain (Species/Organism) Clostridium tetani E88
NCBI Gene ID 1061073
NCBI Protein GI 28373190
Locus Tag pE88_34
Genbank Accession AF528097
Protein Accession NP_783761
Other Database IDs UniProtKB-ID: Q899Y1_CLOTE
UniRef100: UniRef100_Q899Y1
UniRef90: UniRef90_Q899Y1
UniRef50: UniRef50_Q899Y1
UniParc: UPI000000FE49
EMBL: AF528097
EMBL-CDS: AAO37456.1
RefSeq_NT: NC_004565.1
HSSP: Q9S0X0
MEROPS: M09.002
GenomeReviews: AF528097_GR
KEGG: ctc:pE88_33
HOGENOM: HBG339862
ProtClustDB: CLSK912380
Taxonomy ID 212717
Plasmid No pE88
Gene Starting Position 39437
Gene Ending Position 42412
Gene Strand (Orientation) -
Protein Name collagenase ColT
Protein pI 6.12
Protein Weight 110303.28
Protein Length 991
DNA Sequence 
>gi|28373131:39437-42412 Clostridium tetani E88 plasmid pE88, complete sequence
ATTAATTTATTATTACTGAATAATTACCCTTATCACCAGAGTATTTATACACATATAAATAATATTTCCC
AGGACTTAAATTACATTTACCTACTATAGCATTATCTGATTTTGCTCCATAGGCAATATAATTATTTAAA
TCTGATTCTTTATAAAGGTTCCAGGCTATCCCTAAATTATTTAAATTAGTTAGCTTTATATTTAAATCCT
TAGTATTTTCTATATCAAATGAATAAATATCACTAACATCCTTATAATCTAGGTTACCTAATACAAGGGT
ATCAAGTGTAATTTTATTTGCAGTTTCGAAAGAATCATTATTTTCTTTTTCATGAATTTTTTTTATTACT
GGAGCCATATTAGTAGCATCACTTATATTTAACTTATAATTTACTTTATTTAAAGAGGTTTTATAAACTA
ATATATAATATCTACCAGGTTTATGTACTTTAAAACTGCCCATAAGTTTATTATCTTCTTTTTTTGTAGG
GTATGCAATATAATTATTTAAATCCTCATCATTGTAAACAAGCCAATTAAATGCATCAGAATTACCATGA
ATGTTTTCTATAGTTATATCTATACTTCCAGAGGTTAGAGCATCAAAGTAAAAGGTGTCCCTGTAGTCCT
CAGTATCTAAAGTAGCCATTACTATTTGGTTTTTATGAATTTTATTAGCTTTATCAAAAGAATCGTTATT
TTCTTTTTCATATATTACATTTTCAAAGGAATCCTTATCTTTAATTTCTGGCTCCTCTTTAACTTCTACC
TTTTCATTTGAATTTTTATTATGAGATAATAATCCATGGAAAACTATATCATATACTACTTCATTATTTG
AATTTAATCTAGGATTTGAGAAATAAGCAGTTACTGTTTTATATCCTCCCCAGCTTAAATTATCTAGTTT
ATTTAAAGCTTCGTTAATTTTATTATTCATATAATTCCAATTAGAAATTTCCCCTTTATTTGAACTTAAT
GTATAAGTTGCTTTTAAATTATAGGTATCAAAGTATTGGGAACTTTCTTTAGTTATTTGAGAATTTTTTA
CATCCATAGCTTTTTCAATATCTGATTTTATTTCATGTAAAGATTTATTATCATATTGTTTCATATAATC
ATCAGAAACTAATGGTATTGTGTAGTTATCATAATTATTAACTAAGTTTTCCATATGATATTCATAGTCT
TTATTAATTTTAGAATCTTTACTTGATTCTTCTATTAAAGCTTCATAACCTTTAACATCATTATTTTTCA
TGGTAGATACTAAATCACTAAATAATTTCTTGTTGTTATTATACATATAATCTGAGAAAGCATATCCATA
TTTATAAAAATCCCATCCATCACTATATTTTGAATGTAATAATTTATCTGCATTAAATCTTTCTTTAGGA
TTTTTAGAAAGTCCACCTACCATTGATTTTCTTGGTAATACAGAAGTTCTAGTTGAACCTGCAAAAAATT
CTGCAGAGCCTTCTTCAAACCATGTAATTCTTCCATTATTTCCTTTGTAAAAATCACCTTTATTAAATAG
ACCTGGTATTAAGTAACGTCCTTGTAAATAATGAGTGAATTCATGACGAAAAAGTTCTTCTAGGCTATAG
ATGCTTTCCTGTGGAGTTCTTTCATAGGTAAAGAAAGTACCAATTCCTTCAATATATATTCCACCATTAT
CTACACTATATCCATATAAAGTTTTGTTTAGTTTATATTCTTCTGGATTGTTGTATATTACTATAGTTAA
TATATCATCAGCATTGCCTACCTCTAGGGGTTTATCATTACCTATTATCCTATGAAATTGAGATTTTACT
TCTTTAGATGCCCAGTAAAGTTTTTGAATTTTTGATTCTTCTACTTTATCTCCAGCCTTTATAATGATTT
TTCCATTGTCAAAGGTATAAGTTTTAGGTAGATAATGTTTTTTACCTTCTTCTATTAACTTATTAATGTC
TATAACATTGCCCTTTGAGTCCCTTGAATTAAAATCTTCCTTTATTGCCTCTATTGCAGTAAAATATTGT
TCGCTATAATCAGGAAAAATTTCAATGCAATTATCTATTACTGAATGAGGAATAGATGGATTACTGTGGT
ATTTTGAAAGTTTTGCAGTATAATAAATACTATTATTTATAATCCAGCCATTATCCTTTGTAACATTAGA
TATACTTGCAAATTTTGAAATTGTATCTATAAAGGAATCTATTTTACCAGACCAAGGAGTATTTTTATAA
TCTCTAATATTATGAGCATATTCATATTGTGAAATATCATAATTTATTTCTTTCATAAAATTATATACAG
CATTGGATTTTAGTCTATCCTTTGAATACTTATCTATTTCATTATAATATTGTTCTAAAATAGGAATTGT
TTTATTAACTACTTCATCATTGCAAGAAGTATTTCCTATAAGTTTACCTAAAGCATGTACTACTGTATCT
TGACCATTTTCACCTAGTTTGAAATTTTTATTATTTTCTATAGCAATCATTGCTGGAATACATTTATCCT
TAAAAGATTTATCATTTAAGTATTTTAAAGAATCATTATAATATCCTAAATAAAATCCAGATCTTAAAAT
TTCAACTAATGTATCAATTCCTTTGTCATCAGTGCTAGTATAATTACAACCTTTTTCATATAATCCATCT
ATTAAAGCTTGTACACGTTCTTTGTTTGAATAAAAGGTATAACTATCCTTGTTATACTGAAAAAGATCAG
AAATATCACTCCATTTTATTTTTGAAGTTAAATCTAAAATTTCCTTATTACTTAGTTTGTTTAAATCATT
AAAAGAATACTTTGTTTTGTAGGGGTTTGTAGAATTTAAACTTAAGGATTTAAATTCACCATTTGGGTTA
GTTTTAGTATTGCCATTAGAAAAAGCAGATACTTTAATTGAATAGCTTGTACTTATCATACAACCTATAG
CTATGGAACATAGCATTTTAATAAATTTTTTTTTCA
Protein Sequence 
>gi|28373190|ref|NP_783761.1| collagenase ColT [Clostridium tetani E88]
MKKKFIKMLCSIAIGCMISTSYSIKVSAFSNGNTKTNPNGEFKSLSLNSTNPYKTKYSFNDLNKLSNKEI
LDLTSKIKWSDISDLFQYNKDSYTFYSNKERVQALIDGLYEKGCNYTSTDDKGIDTLVEILRSGFYLGYY
NDSLKYLNDKSFKDKCIPAMIAIENNKNFKLGENGQDTVVHALGKLIGNTSCNDEVVNKTIPILEQYYNE
IDKYSKDRLKSNAVYNFMKEINYDISQYEYAHNIRDYKNTPWSGKIDSFIDTISKFASISNVTKDNGWII
NNSIYYTAKLSKYHSNPSIPHSVIDNCIEIFPDYSEQYFTAIEAIKEDFNSRDSKGNVIDINKLIEEGKK
HYLPKTYTFDNGKIIIKAGDKVEESKIQKLYWASKEVKSQFHRIIGNDKPLEVGNADDILTIVIYNNPEE
YKLNKTLYGYSVDNGGIYIEGIGTFFTYERTPQESIYSLEELFRHEFTHYLQGRYLIPGLFNKGDFYKGN
NGRITWFEEGSAEFFAGSTRTSVLPRKSMVGGLSKNPKERFNADKLLHSKYSDGWDFYKYGYAFSDYMYN
NNKKLFSDLVSTMKNNDVKGYEALIEESSKDSKINKDYEYHMENLVNNYDNYTIPLVSDDYMKQYDNKSL
HEIKSDIEKAMDVKNSQITKESSQYFDTYNLKATYTLSSNKGEISNWNYMNNKINEALNKLDNLSWGGYK
TVTAYFSNPRLNSNNEVVYDIVFHGLLSHNKNSNEKVEVKEEPEIKDKDSFENVIYEKENNDSFDKANKI
HKNQIVMATLDTEDYRDTFYFDALTSGSIDITIENIHGNSDAFNWLVYNDEDLNNYIAYPTKKEDNKLMG
SFKVHKPGRYYILVYKTSLNKVNYKLNISDATNMAPVIKKIHEKENNDSFETANKITLDTLVLGNLDYKD
VSDIYSFDIENTKDLNIKLTNLNNLGIAWNLYKESDLNNYIAYGAKSDNAIVGKCNLSPGKYYLYVYKYS
GDKGNYSVIIN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: colT is a collagenase that catalyzes the hydrolysis of collagen in host tissues (Brüggemann and Gottschalk, 2004).
References
Brüggemann and Gottschalk, 2004: Brüggemann H, Gottschalk G. Insights in metabolism and toxin production from the complete genome sequence of Clostridium tetani. Anaerobe. 2004; 10(2); 53-68. [PubMed: 16701501].