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boNT/A3

Victor ID 2565
Gene Name boNT/A3
Sequence Strain (Species/Organism) Clostridium botulinum A3 str. Loch Maree
NCBI Gene ID 6030483
NCBI Protein GI 169835008
Locus Tag CLK_A0076
Genbank Accession CP000963
Protein Accession YP_001715703
Other Database IDs UniProtKB-ID: B1L2G5_CLOBM
UniRef100: UniRef100_B1L2G5
UniRef90: UniRef90_Q45894
UniRef50: UniRef50_Q45894
UniParc: UPI00016DBC11
EMBL: CP000963
EMBL-CDS: ACA57525.1
RefSeq_NT: NC_010418.1
GenomeReviews: CP000963_GR
KEGG: cbl:CLK_A0076
HOGENOM: HBG419785
OMA: LKDFWGN
ProtClustDB: CLSK912378
Taxonomy ID 498214
Plasmid No pCLK
Gene Starting Position 62592
Gene Ending Position 66470
Gene Strand (Orientation) +
Protein Name botulinum neurotoxin type A3
Protein pI 5.44
Protein Weight 140565.68
Protein Length 1292
Protein Note identified by match to protein family HMM PF01742; match to protein family HMM PF07951; match to protein family HMM PF07952; match to protein family HMM PF07953
DNA Sequence 
>gi|169834729:62592-66470 Clostridium botulinum A3 str. Loch Maree plasmid pCLK, complete sequence
TATGCCATTTGTTAATAAACAATTTAATTATAGAGATCCTGTAAATGGTGTTGATATTGCTTATATAAAA
ATTCCAAATGCAGGACAAATGCAACCAGTAAAAGCTTTTAAAATTCATGAAGGAGTATGGGTTATTCCAG
AAAGGGATACCTTTACAAATCCTGAAGAAGGAGATTTAAATCCACCACCAGAAGCAAAACAAGTTCCAGT
CTCATATTATGATTCAACATATTTAAGTACAGATAATGAAAAAGATAATTATTTAAAGGGAGTTATAAAA
TTATTTGACAGAATTTATTCAACTGGGCTTGGAAGAATGTTGTTATCATTCATAGTAAAGGGAATACCAT
TTTGGGGTGGAAGTACAATAGATACAGAATTAAAAGTTATTGATACTAATTGTATTAATGTAATAGAACC
AGGTGGTAGTTATAGATCAGAAGAGCTTAATCTAGTAATAACAGGACCCTCAGCTGATATTATACAGTTT
GAATGTAAAAGTTTTGGACATGACGTTTTTAATCTTACGCGAAATGGTTATGGTTCTACTCAATACATTA
GATTTAGCCCAGATTTTACATTTGGTTTTGAGGAGTCACTTGAAGTTGATACAAATCCTCTTTTAGGTGC
AGGCACATTTGCTACAGATCCAGCGGTAACATTAGCACATGAACTTATACATGCTGCACATAGATTATAT
GGAATAGCAATTAATCCAAATAGGGTTTTAAAAGTAAAGACTAATGCCTATTATGAAATGAGTGGGTTAG
AAGTAAGCTTTGAGGAACTTAGAACATTTGGGGGAAATGATACAAACTTTATAGATAGTTTATGGCAAAA
AAAATTTAGTAGAGACGCTTATGATAATCTTCAAAATATAGCACGTATACTTAATGAAGCTAAAACAATA
GTAGGTACTACTACTCCATTACAGTATATGAAAAATATTTTTATACGGAAATATTTCTTATCTGAAGATG
CATCTGGAAAGATTTCGGTAAATAAAGCAGCATTTAAGGAATTTTACAGGGTGTTAACAAGGGGTTTCAC
AGAGTTAGAATTTGTTAATCCTTTTAAAGTAATTAACAGAAAAACATATTTGAATTTTGATAAAGCCGTA
TTTAGGATAAATATAGTACCTGATGAAAATTACACAATAAATGAGGGATTTAATTTAGAAGGTGCAAATT
CTAATGGTCAGAATACAGAAATTAATAGTAGGAATTTTACTAGATTAAAAAATTTTACAGGATTATTTGA
ATTTTATAAGCTGCTATGTGTAAGAGGGATAATACCTTTTAAAACTAAATCATTAGATGAAGGATACAAT
AAGGCATTAAATGATTTATGTATCAAAGTTAATAATTGGGACTTGTTTTTTAGTCCTTCAGAAGATAATT
TTACTAATGATTTAGATAAAGTAGAAGAAATTACAGCTGATACCAATATAGAAGCAGCAGAAGAAAATAT
TAGTTCAGATTTAATACAACAATATTATTTAACTTTTGATTTTGATAATGAACCTGAAAATATTTCAATA
GAAAATCTTTCAAGTGATATTATAGGCCAATTAGAGCCTATGCCTAATATAGAAAGATTTCCCAATGGAA
AAAAGTATGAGTTAGATAAATATACTATGTTCCATTATCTTCGTGCTCAAGAATTTGAACATGGTGATTC
TAGAATTATCTTAACAAATTCTGCTGAAGAAGCATTATTAAAGCCTAATGTTGCTTACACATTTTTTTCT
TCAAAATATGTAAAGAAGATTAATAAAGCCGTAGAGGCAGTTATTTTTTTAAGTTGGGCAGAAGAGTTAG
TATATGACTTTACCGATGAAACTAATGAAGTAACTACTATGGATAAAATTGCTGATATAACTATAATTGT
TCCATATATAGGGCCTGCTTTAAATATAGGTAATATGGTATCTAAAGGAGAGTTCGTAGAAGCTATACTA
TTTACGGGAGTTGTTGCTCTGTTAGAATTTATACCAGAGTATTCCCTCCCTGTATTTGGTACTTTTGCAA
TTGTATCATATATTGCCAATAAGGTTCTAACTGTTCAAACAATAAATAATGCTTTAAGTAAAAGAAATGA
AAAATGGGATGAAGTCTATAAATATACAGTAACAAATTGGCTAGCAAAGGTTAATACACAGATTGATCTA
ATAAGGGAAAAAATGAAAAAAGCTTTAGAAAATCAGGCAGAAGCAACAAGGGCTATAATAAACTATCAGT
ATAATCAATATACTGAGGAAGAGAAAAATAATATTAATTTTAATATTGATGATTTAAGTTCGAAACTTAA
TAGGTCTATAAATAGGGCTATGATTAACATAAATAAATTTTTGGATCAATGCTCTGTTTCATATTTAATG
AATTCTATGATACCTTATGCTGTTAAACGGTTAAAAGATTTTGATGCTAGTGTTAGAGATGTATTATTAA
AGTATATATATGATAATAGAGGAACTTTAATTCTTCAAGTAGATAGATTAAAAGATGAAGTTAATAATAC
ACTTAGTGCAGATATACCTTTTCAGCTTTCTAAATACGTAAATGATAAAAAATTATTATCTACATTTACT
GAATATATTAAGAATATTGTTAATACCTCTATATTGAGTATAGTATATAAAAAAGATGATTTAATAGATT
TATCTAGGTATGGAGCAAAAATAAATATTGGCGATAGAGTATATTATGATTCAATAGATAAAAATCAAAT
TAAATTAATTAATTTAGAAAGTAGTACAATTGAGGTAATTTTAAAAAATGCTATTGTATATAATAGTATG
TATGAAAATTTTAGTACTAGCTTTTGGATAAAAATTCCTAAGTATTTTAGCAAGATAAATCTAAATAATG
AATATACAATAATAAATTGTATAGAAAATAATTCAGGATGGAAAGTATCACTTAATTATGGTGAAATAAT
CTGGACTTTGCAGGATAATAAGCAAAACATACAAAGAGTAGTTTTTAAATACAGTCAAATGGTTAATATA
TCAGATTATATAAACAGATGGATGTTTGTAACTATCACTAATAATAGACTAACTAAATCTAAAATTTATA
TAAATGGAAGATTAATAGATCAAAAACCAATTTCAAATTTGGGTAATATTCATGCTAGTAATAAGATAAT
GTTTAAATTAGATGGCTGTAGAGATCCACGTAGATACATCATGATAAAATATTTCAATCTTTTCGATAAA
GAATTAAATGAAAAAGAAATCAAAGATTTATATGATAGTCAATCAAATCCAGGTATTTTAAAAGACTTTT
GGGGTAATTATTTACAATATGATAAACCATACTATATGTTAAATTTATTTGATCCAAATAAATATGTCGA
TGTAAATAATATAGGTATTAGAGGTTATATGTATCTTAAAGGGCCTAGAGGTAGCGTAATGACTACAAAC
ATTTATTTAAATTCAACTTTGTATATGGGGACAAAATTTATTATAAAAAAATATGCTTCTGGAAATGAAG
ATAATATTGTTAGAAATAATGATCGTGTATATATTAATGTAGTAGTTAAAAATAAAGAATATAGGTTAGC
TACTAATGCATCACAGGCAGGCGTAGAAAAAATACTAAGTGCATTAGAAATACCTGATGTAGGAAATCTA
AGTCAAGTAGTAGTAATGAAGTCAAAAGATGATCAAGGAATAAGAAATAAATGCAAAATGAATTTACAAG
ATAATAATGGGAATGATATAGGCTTTGTAGGATTTCATTTGTATGATAATATAGCTAAACTAGTAGCAAG
TAATTGGTATAATAGACAAGTGGGAAAAGCTAGTAGGACTTTCGGTTGTTCATGGGAGTTTATTCCTGTA
GATGATGGATGGGGAGAAAGTTCACTGTA
Protein Sequence 
>gi|169835008|ref|YP_001715703.1| botulinum neurotoxin type A3 [Clostridium botulinum A3 str. Loch Maree]
MPFVNKQFNYRDPVNGVDIAYIKIPNAGQMQPVKAFKIHEGVWVIPERDTFTNPEEGDLNPPPEAKQVPV
SYYDSTYLSTDNEKDNYLKGVIKLFDRIYSTGLGRMLLSFIVKGIPFWGGSTIDTELKVIDTNCINVIEP
GGSYRSEELNLVITGPSADIIQFECKSFGHDVFNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGA
GTFATDPAVTLAHELIHAAHRLYGIAINPNRVLKVKTNAYYEMSGLEVSFEELRTFGGNDTNFIDSLWQK
KFSRDAYDNLQNIARILNEAKTIVGTTTPLQYMKNIFIRKYFLSEDASGKISVNKAAFKEFYRVLTRGFT
ELEFVNPFKVINRKTYLNFDKAVFRINIVPDENYTINEGFNLEGANSNGQNTEINSRNFTRLKNFTGLFE
FYKLLCVRGIIPFKTKSLDEGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLDKVEEITADTNIEAAEENI
SSDLIQQYYLTFDFDNEPENISIENLSSDIIGQLEPMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGDS
RIILTNSAEEALLKPNVAYTFFSSKYVKKINKAVEAVIFLSWAEELVYDFTDETNEVTTMDKIADITIIV
PYIGPALNIGNMVSKGEFVEAILFTGVVALLEFIPEYSLPVFGTFAIVSYIANKVLTVQTINNALSKRNE
KWDEVYKYTVTNWLAKVNTQIDLIREKMKKALENQAEATRAIINYQYNQYTEEEKNNINFNIDDLSSKLN
RSINRAMININKFLDQCSVSYLMNSMIPYAVKRLKDFDASVRDVLLKYIYDNRGTLILQVDRLKDEVNNT
LSADIPFQLSKYVNDKKLLSTFTEYIKNIVNTSILSIVYKKDDLIDLSRYGAKINIGDRVYYDSIDKNQI
KLINLESSTIEVILKNAIVYNSMYENFSTSFWIKIPKYFSKINLNNEYTIINCIENNSGWKVSLNYGEII
WTLQDNKQNIQRVVFKYSQMVNISDYINRWMFVTITNNRLTKSKIYINGRLIDQKPISNLGNIHASNKIM
FKLDGCRDPRRYIMIKYFNLFDKELNEKEIKDLYDSQSNPGILKDFWGNYLQYDKPYYMLNLFDPNKYVD
VNNIGIRGYMYLKGPRGSVMTTNIYLNSTLYMGTKFIIKKYASGNEDNIVRNNDRVYINVVVKNKEYRLA
TNASQAGVEKILSALEIPDVGNLSQVVVMKSKDDQGIRNKCKMNLQDNNGNDIGFVGFHLYDNIAKLVAS
NWYNRQVGKASRTFGCSWEFIPVDDGWGESSL
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: BoNT/A3 is a neurotoxin with prolonged effects (Smith et al., 2007)
References
Smith et al., 2007: Smith TJ, Hill KK, Foley BT, Detter JC, Munk AC, Bruce DC, Doggett NA, Smith LA, Marks JD, Xie G, Brettin TS. Analysis of the neurotoxin complex genes in Clostridium botulinum A1-A4 and B1 strains: BoNT/A3, /Ba4 and /B1 clusters are located within plasmids. PloS one. 2007; 2(12); e1271. [PubMed: 18060065].