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boNT/A1 from Clostridium botulinum A str. Hall

Victor ID 2563
Gene Name boNT/A1 from Clostridium botulinum A str. Hall
Sequence Strain (Species/Organism) Clostridium botulinum A str. Hall
NCBI Gene ID 5398487
NCBI Protein GI 153936924
Locus Tag CLC_0862
Protein Accession YP_001386738.1
Other Database IDs UniProtKB-ID: BXA1_CLOBH
UniRef100: UniRef100_A5HZZ9
UniRef90: UniRef90_A5HZZ9
UniRef50: UniRef50_A5HZZ9
UniParc: UPI0000001386
EMBL: AM412317
EMBL: CP000727
EMBL-CDS: CAL82360.1
EMBL-CDS: ABS38337.1
RefSeq_NT: NC_009495.1
RefSeq_NT: NC_009698.1
PDB: 1XTF
PDB: 1XTG
PDB: 2W2D
PDB: 3K3Q
GenomeReviews: AM412317_GR
GenomeReviews: CP000727_GR
KEGG: cbh:CLC_0862
KEGG: cbo:CBO0806
HOGENOM: HBG419785
OMA: LKDFWGN
ProtClustDB: CLSK912378
BioCyc: CBOT36826:CBO0806-MONOMER
BioCyc: CBOT441771:CLC_0862-MONOM
Taxonomy ID 441771
Gene Starting Position 882202
Gene Ending Position 886092
Gene Strand (Orientation) +
Protein Name botulinum neurotoxin type A1, BoNT/A1
DNA Sequence 
>gi|153934468:882202-886092 Clostridium botulinum A str. Hall, complete genome
TATGCCATTTGTTAATAAACAATTTAATTATAAAGATCCTGTAAATGGTGTTGATATTGCTTATATAAAA
ATTCCAAATGCAGGACAAATGCAACCAGTAAAAGCTTTTAAAATTCATAATAAAATATGGGTTATTCCAG
AAAGAGATACATTTACAAATCCTGAAGAAGGAGATTTAAATCCACCACCAGAAGCAAAACAAGTTCCAGT
TTCATATTATGATTCAACATATTTAAGTACAGATAATGAAAAAGATAATTATTTAAAGGGAGTTACAAAA
TTATTTGAGAGAATTTATTCAACTGATCTTGGAAGAATGTTGTTAACATCAATAGTAAGGGGAATACCAT
TTTGGGGTGGAAGTACAATAGATACAGAATTAAAAGTTATTGATACTAATTGTATTAATGTGATACAACC
AGATGGTAGTTATAGATCAGAAGAACTTAATCTAGTAATAATAGGACCCTCAGCTGATATTATACAGTTT
GAATGTAAAAGCTTTGGACATGAAGTTTTGAATCTTACGCGAAATGGTTATGGCTCTACTCAATACATTA
GATTTAGCCCAGATTTTACATTTGGTTTTGAGGAGTCACTTGAAGTTGATACAAATCCTCTTTTAGGTGC
AGGCAAATTTGCTACAGATCCAGCAGTAACATTAGCACATGAACTTATACATGCTGGACATAGATTATAT
GGAATAGCAATTAATCCAAATAGGGTTTTTAAAGTAAATACTAATGCCTATTATGAAATGAGTGGGTTAG
AAGTAAGCTTTGAGGAACTTAGAACATTTGGGGGACATGATGCAAAGTTTATAGATAGTTTACAGGAAAA
CGAATTTCGTCTATATTATTATAATAAGTTTAAAGATATAGCAAGTACACTTAATAAAGCTAAATCAATA
GTAGGTACTACTGCTTCATTACAGTATATGAAAAATGTTTTTAAAGAGAAATATCTCCTATCTGAAGATA
CATCTGGAAAATTTTCGGTAGATAAATTAAAATTTGATAAGTTATACAAAATGTTAACAGAGATTTACAC
AGAGGATAATTTTGTTAAGTTTTTTAAAGTACTTAACAGAAAAACATATTTGAATTTTGATAAAGCCGTA
TTTAAGATAAATATAGTACCTAAGGTAAATTACACAATATATGATGGATTTAATTTAAGAAATACAAATT
TAGCAGCAAACTTTAATGGTCAAAATACAGAAATTAATAATATGAATTTTACTAAACTAAAAAATTTTAC
TGGATTGTTTGAATTTTATAAGTTGCTATGTGTAAGAGGGATAATAACTTCTAAAACTAAATCATTAGAT
AAAGGATACAATAAGGCATTAAATGATTTATGTATCAAAGTTAATAATTGGGACTTGTTTTTTAGTCCTT
CAGAAGATAATTTTACTAATGATCTAAATAAAGGAGAAGAAATTACATCTGATACTAATATAGAAGCAGC
AGAAGAAAATATTAGTTTAGATTTAATACAACAATATTATTTAACCTTTAATTTTGATAATGAACCTGAA
AATATTTCAATAGAAAATCTTTCAAGTGACATTATAGGCCAATTAGAACTTATGCCTAATATAGAAAGAT
TTCCTAATGGAAAAAAGTATGAGTTAGATAAATATACTATGTTCCATTATCTTCGTGCTCAAGAATTTGA
ACATGGTAAATCTAGGATTGCTTTAACAAATTCTGTTAACGAAGCATTATTAAATCCTAGTCGTGTTTAT
ACATTTTTTTCTTCAGACTATGTAAAGAAAGTTAATAAAGCTACGGAGGCAGCTATGTTTTTAGGCTGGG
TAGAACAATTAGTATATGATTTTACCGATGAAACTAGCGAAGTAAGTACTACGGATAAAATTGCGGATAT
AACTATAATTATTCCATATATAGGACCTGCTTTAAATATAGGTAATATGTTATATAAAGATGATTTTGTA
GGTGCTTTAATATTTTCAGGAGCTGTTATTCTGTTAGAATTTATACCAGAGATTGCAATACCTGTATTAG
GTACTTTTGCACTTGTATCATATATTGCGAATAAGGTTCTAACCGTTCAAACAATAGATAATGCTTTAAG
TAAAAGAAATGAAAAATGGGATGAGGTCTATAAATATATAGTAACAAATTGGTTAGCAAAGGTTAATACA
CAGATTGATCTAATAAGAAAAAAAATGAAAGAAGCTTTAGAAAATCAAGCAGAAGCAACAAAGGCTATAA
TAAACTATCAGTATAATCAATATACTGAGGAAGAGAAAAATAATATTAATTTTAATATTGATGATTTAAG
TTCGAAACTTAATGAGTCTATAAATAAAGCTATGATTAATATAAATAAATTTTTGAATCAATGCTCTGTT
TCATATTTAATGAATTCTATGATCCCTTATGGTGTTAAACGGTTAGAAGATTTTGATGCTAGTCTTAAAG
ATGCATTATTAAAGTATATATATGATAATAGAGGAACTTTAATTGGTCAAGTAGATAGATTAAAAGATAA
AGTTAATAATACACTTAGTACAGATATACCTTTTCAGCTTTCCAAATACGTAGATAATCAAAGATTATTA
TCTACATTTACTGAATATATTAAGAATATTATTAATACTTCTATATTGAATTTAAGATATGAAAGTAATC
ATTTAATAGACTTATCTAGGTATGCATCAAAAATAAATATTGGTAGTAAAGTAAATTTTGATCCAATAGA
TAAAAATCAAATTCAATTATTTAATTTAGAAAGTAGTAAAATTGAGGTAATTTTAAAAAATGCTATTGTA
TATAATAGTATGTATGAAAATTTTAGTACTAGCTTTTGGATAAGAATTCCTAAGTATTTTAACAGTATAA
GTCTAAATAATGAATATACAATAATAAATTGTATGGAAAATAATTCAGGATGGAAAGTATCACTTAATTA
TGGTGAAATAATCTGGACTTTACAGGATACTCAGGAAATAAAACAAAGAGTAGTTTTTAAATACAGTCAA
ATGATTAATATATCAGATTATATAAACAGATGGATTTTTGTAACTATCACTAATAATAGATTAAATAACT
CTAAAATTTATATAAATGGAAGATTAATAGATCAAAAACCAATTTCAAATTTAGGTAATATTCATGCTAG
TAATAATATAATGTTTAAATTAGATGGTTGTAGAGATACACATAGATATATTTGGATAAAATATTTTAAT
CTTTTTGATAAGGAATTAAATGAAAAAGAAATCAAAGATTTATATGATAATCAATCAAATTCAGGTATTT
TAAAAGACTTTTGGGGTGATTATTTACAATATGATAAACCATACTATATGTTAAATTTATATGATCCAAA
TAAATATGTCGATGTAAATAATGTAGGTATTAGAGGTTATATGTATCTTAAAGGGCCTAGAGGTAGCGTA
ATGACTACAAACATTTATTTAAATTCAAGTTTGTATAGGGGGACAAAATTTATTATAAAAAAATATGCTT
CTGGAAATAAAGATAATATTGTTAGAAATAATGATCGTGTATATATTAATGTAGTAGTTAAAAATAAAGA
ATATAGGTTAGCTACTAATGCATCACAGGCAGGCGTAGAAAAAATACTAAGTGCATTAGAAATACCTGAT
GTAGGAAATCTAAGTCAAGTAGTAGTAATGAAGTCAAAAAATGATCAAGGAATAACAAATAAATGCAAAA
TGAATTTACAAGATAATAATGGGAATGATATAGGCTTTATAGGATTTCATCAGTTTAATAATATAGCTAA
ACTAGTAGCAAGTAATTGGTATAATAGACAAATAGAAAGATCTAGTAGGACTTTGGGTTGCTCATGGGAA
TTTATTCCTGTAGATGATGGATGGGGAGAAAGGCCACTGTA
Protein Sequence 
>gi|153936924|ref|YP_001386738.1| botulinum neurotoxin type A1 [Clostridium botulinum A str. Hall] MPFVNKQFNYKDPVNGVDIAYIKIPNAGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLKNFTGLFEFYKLLCVRGIITSKTKSLDKGYNKALNDLCIKVNNWDLFFSPSEDNFTNDLNKGEEITSDTNIEAAEENISLDLIQQYYLTFNFDNEPENISIENLSSDIIGQLELMPNIERFPNGKKYELDKYTMFHYLRAQEFEHGKSRIALTNSVNEALLNPSRVYTFFSSDYVKKVNKATEAAMFLGWVEQLVYDFTDETSEVSTTDKIADITIIIPYIGPALNIGNMLYKDDFVGALIFSGAVILLEFIPEIAIPVLGTFALVSYIANKVLTVQTIDNALSKRNEKWDEVYKYIVTNWLAKVNTQIDLIRKKMKEALENQAEATKAIINYQYNQYTEEEKNNINFNIDDLSSKLNESINKAMININKFLNQCSVSYLMNSMIPYGVKRLEDFDASLKDALLKYIYDNRGTLIGQVDRLKDKVNNTLSTDIPFQLSKYVDNQRLLSTFTEYIKNIINTSILNLRYESNHLIDLSRYASKINIGSKVNFDPIDKNQIQLFNLESSKIEVILKNAIVYNSMYENFSTSFWIRIPKYFNSISLNNEYTIINCMENNSGWKVSLNYGEIIWTLQDTQEIKQRVVFKYSQMINISDYINRWIFVTITNNRLNNSKIYINGRLIDQKPISNLGNIHASNNIMFKLDGCRDTHRYIWIKYFNLFDKELNEKEIKDLYDNQSNSGILKDFWGDYLQYDKPYYMLNLYDPNKYVDVNNVGIRGYMYLKGPRGSVMTTNIYLNSSLYRGTKFIIKKYASGNKDNIVRNNDRVYINVVVKNKEYRLATNASQAGVEKILSALEIPDVGNLSQVVVMKSKNDQGITNKCKMNLQDNNGNDIGFIGFHQFNNIAKLVASNWYNRQIERSSRTLGCSWEFIPVDDGWGERPL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a BoNT/A mutant was rendered nontoxigenic (Bradshaw et al., 2010)
References
Bradshaw et al., 2010: Bradshaw M, Marshall KM, Heap JT, Tepp WH, Minton NP, Johnson EA. Construction of a nontoxigenic Clostridium botulinum strain for food challenge studies. Applied and environmental microbiology. 2010; 76(2); 387-393. [PubMed: 19933346].