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VC0647

Victor ID 2469
Gene Name VC0647
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2615437
NCBI Protein GI 15640667
Locus Tag VC0647
Genbank Accession AE003852
Protein Accession NP_230296
Other Database IDs UniProtKB-ID: PNP_VIBCH
UniRef100: UniRef100_C3LSQ2
UniRef90: UniRef90_A5F913
UniRef50: UniRef50_B8DFZ6
UniParc: UPI00000C2D5C
EMBL: AE003852
EMBL-CDS: AAF93813.1
RefSeq_NT: NC_002505.1
HSSP: P05055
GenomeReviews: AE003852_GR
KEGG: vch:VC0647
TIGR: VC_0647
HOGENOM: HBG382411
OMA: YGETVVL
ProtClustDB: PRK11824
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 690244
Gene Ending Position 692373
Gene Strand (Orientation) +
Protein Name polynucleotide phosphorylase/polyadenylase
Protein pI 4.79
Protein Weight 69641.8
Protein Length 709
Protein Note similar to GB:J02638 SP:P05055 GB:M14425 GB:X00761 PID:147749; identified by sequence similarity; putative
DNA Sequence 
>gi|15640032:690244-692373 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
CATGTTCGAAAAACCAGTAGTAAAAACGTTTCAGTACGGTAACCACACCGTTACTCTCGAAACGGGTGTA
ATGGCTCGCCAAGCAACGGCAGCAGTAATGGCTACCATGGATGACACTGCGGTGTTTGTCTCTGTGGTCG
GTAAGAAAGAAGCGGTAGTGGGTCAAGATTTCTTCCCTCTGACTGTAAACTACCAAGAGCGTACTTACGC
GGCAGGTAAAATCCCTGGCGGTTTCTTTAAGCGCGAAGGTCGTCCTTCTGAAGGCGAAACGCTGATTGCT
CGTCTGATTGACCGTCCAATTCGTCCGCTGTTCCCTGATGGTTTCACTAACGAAGTGCAAGTGATCGCGA
CTGTGGTTTCAGTAAACCCAGACGTGCAACCTGACATCATCTCGATGATCGGTACTTCTGCAGCACTGGC
GATTTCTGGACTCCCATTCAATGGTCCAATCGGTGCGGCTCGCGTAGGTCACATTGATGGTCAATTGGTT
CTGAACCCAAGTGAAAAAGAGCTGAAACAGTCTCGTTTGGATCTGGTGGTTGCGGGTACTGACAACGCAG
TACTGATGGTGGAATCAGAAGCACAAATTCTGACTGAAGAAGAGATGCTGGCTGCCGTTGTGTTTGGTCA
CGATCAACAACAAGCCGTGATCAAAGCAATCAATGAATTCGCAGCGGAAGTTGCAACACCAGCATGGGAA
TGGGTTGCACCAGCCGAGAACACTGAGCTGAAAGCGAAAGTGGCTGCTCTGGCAGAAACTCGTTTGGTGG
AAGCGTACCAAATCACTGAGAAAATGGCGCGTTATGATCGTATCCATGAAATCAGTGCAGAAGTCACGGC
GGCTCTGCTGGCTGAAAACGAAGCTTTAGACACCAAAGAAATTCACACCATTTTCCACGATCTGGAAAAA
ACCGTTGTTCGTCGCAGCATCATCGCGGGTAACCCACGTATCGATGGCCGTGAAAAAGACATGGTTCGTG
CTCTGGACGTTCGTACTGGCGTTCTGCCACGTACTCACGGCTCTGCTCTGTTCACACGTGGTGAAACTCA
GGCTCTGGTTACCGCAACTCTAGGCACTCAGCGTGATGCGCAAATCATCGATGAGCTGACTGGCGAGAAG
AAAGATCACTTCCTACTGCACTACAACTTCCCTCCATACTGTGTGGGTGAAACGGGTTTTGTGGGTTCTC
CTAAGCGTCGCGAAATCGGTCACGGCCGTTTGGCGAAGCGTGGTATTGCTGCGGTTATGCCATCACCAGA
AGAGTTCCCGTACACAGTACGTGTCGTTTCTGAAATCACGGAATCTAACGGTTCATCTTCAATGGCTTCT
GTGTGTGGTTCATCGCTTGCTCTGATGGATGCCGGTGTTCCAATCAAGGCTTCTGTTGCGGGTATCGCAA
TGGGTCTGGTGAAAGAAGAAAATGATTTCGTGGTTCTGTCTGACATCCTAGGTGATGAAGATCACCTTGG
CGACATGGACTTTAAAGTCGCGGGTACCGCGACAGGTGTTACTGCACTGCAGATGGACATCAAGATCGAA
GGTATCACCAAAGAGATCATGCAAATCGCTCTGAACCAAGCGAAAGGTGCTCGTCTACACATTCTGTCTG
TGATGGATCAAGCGATCTCTGCAGCGCGTAGCGATATCTCTGAATTTGCGCCACGTATCCACACGATGAA
GATCAGCGTTGAGAAGATCAAAGACGTGATCGGTAAAGGCGGTGCGGTAATTCGTCAGTTGACGGAAGAA
ACGGGTACCACCATCGAGATCGAAGATGACGGCACGATCAAGATTGCTGCGACTGACGGCGATCAAGCGA
AAGAAGCGATCCGCCGTATTCAAGAGATCACCGCCGAAGTTGAAGTGGGCGTGATCTACACTGGTAAAGT
AGCTCGTTTGGCAGACTTTGGTGCGTTTGTAACGATTCTTCCTGGTAAAGATGGTCTAGTACACATCTCT
CAAATCGCTGACAAGCGCGTAGAGAAAGTGTCTGACTACCTGACTGAAGGCCAAGAAGTTCAAGTTAAAG
TGCTGGAAATCGACCGCCAAGGCCGTGTACGTCTAAGCATGAAAGAAGCGGTTGAAACTTCTGATGCTGC
AGCAGCAGAAGTGGCACCACAAGCGGAATA
Protein Sequence 
>gi|15640667|ref|NP_230296.1| polynucleotide phosphorylase/polyadenylase [Vibrio cholerae O1 biovar El Tor str. N16961]
MFEKPVVKTFQYGNHTVTLETGVMARQATAAVMATMDDTAVFVSVVGKKEAVVGQDFFPLTVNYQERTYA
AGKIPGGFFKREGRPSEGETLIARLIDRPIRPLFPDGFTNEVQVIATVVSVNPDVQPDIISMIGTSAALA
ISGLPFNGPIGAARVGHIDGQLVLNPSEKELKQSRLDLVVAGTDNAVLMVESEAQILTEEEMLAAVVFGH
DQQQAVIKAINEFAAEVATPAWEWVAPAENTELKAKVAALAETRLVEAYQITEKMARYDRIHEISAEVTA
ALLAENEALDTKEIHTIFHDLEKTVVRRSIIAGNPRIDGREKDMVRALDVRTGVLPRTHGSALFTRGETQ
ALVTATLGTQRDAQIIDELTGEKKDHFLLHYNFPPYCVGETGFVGSPKRREIGHGRLAKRGIAAVMPSPE
EFPYTVRVVSEITESNGSSSMASVCGSSLALMDAGVPIKASVAGIAMGLVKEENDFVVLSDILGDEDHLG
DMDFKVAGTATGVTALQMDIKIEGITKEIMQIALNQAKGARLHILSVMDQAISAARSDISEFAPRIHTMK
ISVEKIKDVIGKGGAVIRQLTEETGTTIEIEDDGTIKIAATDGDQAKEAIRRIQEITAEVEVGVIYTGKV
ARLADFGAFVTILPGKDGLVHISQIADKRVEKVSDYLTEGQEVQVKVLEIDRQGRVRLSMKEAVETSDAA
AAEVAPQAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0647 mutant is attenuated in mice (Merrell et al., 2002).
COG COG1185J, under J: Translation, ribosomal structure and biogenesis
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].