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VC2506

Victor ID 2462
Gene Name VC2506
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2615170
NCBI Protein GI 15642502
Locus Tag VC2506
Genbank Accession AE003852
Protein Accession NP_232135
Other Database IDs UniProtKB-ID: RAPA_VIBCH
UniRef100: UniRef100_C3LR47
UniRef90: UniRef90_A5F5C5
UniRef50: UniRef50_A7MSB2
UniParc: UPI00000C3300
EMBL: AE003852
EMBL-CDS: AAF95648.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC2506
TIGR: VC_2506
HOGENOM: HBG290025
OMA: WDLMVVD
ProtClustDB: PRK04914
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2693487
Gene Ending Position 2696396
Gene Strand (Orientation) -
Protein Name ATP-dependent helicase HepA
Protein pI 4.8
Protein Weight 102395.36
Protein Length 969
Protein Note transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
DNA Sequence 
>gi|15640032:2693487-2696396 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
ATCAGTTGTGTGCCACCACAATCAAACGCAGTGAATCCAGCTGATACTGCGCCTGCGCAATATAGCCAGT
CAGCTCTTTGATTTGCTGATCCAGCACTTCGATCTCTTCATCACGAATGTTCGGGTTAACCGCTTTGAGT
GCCAGCAAACGCTCCAACTCGCTGTTAAGGCTCTGCTGCATATCACGCTGCGCTTGTTCACGAATCGCGC
TCACTCGTGGTTCAACCGCAGTTTCGCTTGCCGTAATCAAACGATGCACGTCATGCTGTACTGAGCTCAC
CAACTTGCTGGCCAAATGACGATTCACAGGGCTAAGCTGACGGTTAAAGCTTTCAAACTCCACTTGCGAA
GAGAGATCATTACCGCGCGCATCCATCAGAATTCGGATTGGCGAGACTGGCAAGAAGCGGCTGATGCCAC
TGCGTTTCGGCGCTTGGGCATCCACCACATACACCAGCTCCAGCAAGATGGTACCCACTGGCAGTGCTTT
GTTTTTCAACAGCGACACCGCGCAAGTGCCCACCCCTTCACTCATCAGCAAATCAATGCCACCTTGCACC
ATGGGGTGTTCCCAACTGATGAAGTGCATATCTTCACGCGACAGTGCGGTGTCACGATCAAAAGTAATGG
TGGCGCCTTCATAAGGGAGGCCCGGATAGCTTGGCACCATCATGTGTTCAGCAGGAGTGACCACCAACGC
ATTCTCGCCACGATCTTCCTGATGCAGACCAATCGCATCAAACAGGCTCAAAGCAAACGTCACCAGATTG
GTATCGCCATCGGTTTTCGCGATCTGCTCAGCAATCTGCTGCGCTTTTTCGCCACCGTTAGAATGCATTT
CCAGCAAGCGATCACGCCCCACTTCCAGCTGTGATTTCAGTGTTTTGTTGAGCTTGGCTGACTCTTCGAT
GATCACTTCCAACTCTTCACCGCCACCGGCGGCCAGAATGGGGATCAAACGCTCAGCGAAGGCATCATAC
ACCGCACGACCGGTTGGGCAGGTTTCCGCAAAGGCATTCAAACCTTCTTGAAACCAACGCGCCAAAATCG
CTTGTGACGTTTCGGTCAGATATGGCACGTACACATCGATATCACGTTTTTGGCCGATACGGTCCAAACG
TCCGATACGCTGCTCTAGCAAGTCTGGGTTGAACGGCAGATCGAACATCACCAACTGGTTAGCAAACTGG
AAATTACGACCTTCCGAGCCAATTTCACTACAGATCAGCACCTGCGCGCCGCCCTCTTCTTGGGCAAAAT
AAGCCGCGGCTTTATCGCGTTCAATGATCGACATGCCTTCATGGAATACCGTTGCACGAATGCCTTCACG
CTCACGCAGTGCCTGCTCTAGCTGCAATGCGGTACTGGCACGTGAAGCGATGACGAGGATCTTCTCGCTG
CGTTTGGCTTTGACTTTTTCGAGCAGCCAGTTGACGCGTGAGTCAAATTGCCACCAGCTTGACTCCTCGC
CTTCAAACTCTTGGAAAATCTCTTCTGGGTAGAGCATTTTCATCGCGCGCGCTTCTGGCGTCAGTTTACC
GCCGAGCATGCCCGCAACACGCATTGACGTGGTGTATTGAGAAGGAATCTCCAATGGCAGCAAATGCACA
TTACGCACAGGGAAGCCTTTGATAGCGGCACGCGTGTTACGGAACAGCACGCGACCAGTACCGTGGCGAT
CCATCAGATTGTCAATCAGCTCTTGGCGAGCCAAAGCAATTTCGTCCTCGCTGGCGTGGCTTTCCAACGC
TTTAAATAGCGGCTCGACATCCTGCTCAGACAGAAGCTCAGTGATTTTATTTTTCGCTTCATCACTCAGC
TTCTCACCGCTGAACAGCGCAGTAACCGCATCCGCAACCGGTGCGTACTGCTCTTCTTCTTTAACAAAAG
CTTCGTAATCGTAGAAACGATCTGCATCCAGCAAGCGCAGACGAGCAAAGTGGCTTTCACGACCTAACTG
CTCAGGCGTTGCCGTCAATAGCAATACGCCAGGAGTCTGTTCGGCCAAAGCTTCAATCACTTGATATTCG
CGGCTTGGCTTCTCTGGGTGCCACTCAAGATGGTGAGCTTCATCGACGACCAACAAATCCCATTCCGCTT
CCAACGCTTGTTCAAAACGCTGGCGGCTTTTACGCAAGAAATCGAGTGAACACAGCACATACTGCTGAGT
TTCAAATGGGTTATCGGCCTCGCTAAAGGCTTCCACACAGCGCTCTTCATCAAAAATCGAAAAGTGCAGG
TTGAAACGGCGCATCATCTCCACCAACCATTGGTGTTGCAGCGTTTCAGGTACCACAATTAGGATGCGCT
CGGCACGCCCGGTCAGCACTTGCTGATGGATGATCATGCCCGCTTCGATGGTTTTACCCAAACCGACTTC
ATCGGCTAACAATACGCGTGGCGCATGGCGGCGACCGACTTCATGGGCGATGTACAGCTGATGCGGGATC
AGCCCAGCGCGCATACCACACAAGCCACGCATTGGGCTTTTGTGCTGTTGATATTGATTGGTAAGAGCGC
GATAACGCAGCACAAAGTTGTCCATGCGATCGATTTGACCGGCAAACAACTTATCCTGCGGTTTATTAAA
ACGAATTTGGTTACTGAGGAAAATTTCACGCAGCGCGACACCGCTTTCTTCGGTATCCACTCGCGTACCT
AGATAGGTGTAGACGCCTTGGTCTTCCACCACTTGTTCAACTTGTAACGACCAGCCTTGCTGACTATCCA
CCACATCGCCGACATTGAAGATCACACGGGTGACCGGCGCATCTGAACGTGCATACACACGATTTTCTTC
CGATGCTGCAAACATCAAGGTCACTGTACGCGCATCAAGCGCCACCACAGTACCTAACCCGAGATCACTT
TCCGTATCGCTTATCCAGCGTTGCCCTAAAGCAAATGACA
Protein Sequence 
>gi|15642502|ref|NP_232135.1| ATP-dependent helicase HepA [Vibrio cholerae O1 biovar El Tor str. N16961]
MSFALGQRWISDTESDLGLGTVVALDARTVTLMFAASEENRVYARSDAPVTRVIFNVGDVVDSQQGWSLQ
VEQVVEDQGVYTYLGTRVDTEESGVALREIFLSNQIRFNKPQDKLFAGQIDRMDNFVLRYRALTNQYQQH
KSPMRGLCGMRAGLIPHQLYIAHEVGRRHAPRVLLADEVGLGKTIEAGMIIHQQVLTGRAERILIVVPET
LQHQWLVEMMRRFNLHFSIFDEERCVEAFSEADNPFETQQYVLCSLDFLRKSRQRFEQALEAEWDLLVVD
EAHHLEWHPEKPSREYQVIEALAEQTPGVLLLTATPEQLGRESHFARLRLLDADRFYDYEAFVKEEEQYA
PVADAVTALFSGEKLSDEAKNKITELLSEQDVEPLFKALESHASEDEIALARQELIDNLMDRHGTGRVLF
RNTRAAIKGFPVRNVHLLPLEIPSQYTTSMRVAGMLGGKLTPEARAMKMLYPEEIFQEFEGEESSWWQFD
SRVNWLLEKVKAKRSEKILVIASRASTALQLEQALREREGIRATVFHEGMSIIERDKAAAYFAQEEGGAQ
VLICSEIGSEGRNFQFANQLVMFDLPFNPDLLEQRIGRLDRIGQKRDIDVYVPYLTETSQAILARWFQEG
LNAFAETCPTGRAVYDAFAERLIPILAAGGGEELEVIIEESAKLNKTLKSQLEVGRDRLLEMHSNGGEKA
QQIAEQIAKTDGDTNLVTFALSLFDAIGLHQEDRGENALVVTPAEHMMVPSYPGLPYEGATITFDRDTAL
SREDMHFISWEHPMVQGGIDLLMSEGVGTCAVSLLKNKALPVGTILLELVYVVDAQAPKRSGISRFLPVS
PIRILMDARGNDLSSQVEFESFNRQLSPVNRHLASKLVSSVQHDVHRLITASETAVEPRVSAIREQAQRD
MQQSLNSELERLLALKAVNPNIRDEEIEVLDQQIKELTGYIAQAQYQLDSLRLIVVAHN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC2506 mutant is attenuated in mice (Merrell et al., 2002).
COG COG0553KL, under K: Transcription; L: Replication, recombination and repair
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].