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VC0468

Victor ID 2461
Gene Name VC0468
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2615130
NCBI Protein GI 15640495
Locus Tag VC0468
Genbank Accession AE003852
Protein Accession NP_230122
Other Database IDs UniProtKB-ID: GSHB_VIBCH
UniRef100: UniRef100_Q9KUP7
UniRef90: UniRef90_Q9KUP7
UniRef50: UniRef50_Q7MHK1
UniParc: UPI000012BBD4
EMBL: AE003852
EMBL-CDS: AAF93641.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC0468
TIGR: VC_0468
HOGENOM: HBG624526
OMA: WMRKDPP
ProtClustDB: PRK05246
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 496897
Gene Ending Position 497853
Gene Strand (Orientation) -
Protein Name glutathione synthetase
Protein pI 4.95
Protein Weight 33621.34
Protein Length 318
Protein Note catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
DNA Sequence 
>gi|15640032:496897-497853 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
CTCACATCGCCGTCGCTTTTAAGCGACGCTCAATGGCATCCATCAGCTTGCCTGTGATTGAAATATCGTA
CGCAGCTTCAATCTCTCGAATGCAGGTTGGGCTGGTGACGTTAATTTCGGTCAGTTTATCGCCAATGACA
TCTAAGCCTACAAACAGCAGCCCTTTCTCTTTGAGAGTCGGTGCGACCGCTAGGGCAATTTTCTTATCGG
TTTCACTCAGTGGGCGAGGCTCACCACGACCGCCAGCCGCCAAGTTACCGCGGGTTTCCCCTTTGGCGGG
GATACGCGCCAAGCAGTAAGGCATAGGTTCACCATCGACCACCAAAATGCGTTTATCACCGTTGCTGATA
TCTGGCACAAAGGTCTGCGCCATGCAGTAATTCTGGCCGTGGTTGGTTAAGGTTTCGATGATCACTGAGA
GGTTTGGATCGCCCTCTTTAACGCGGAAAATCGAAGCACCGCCCATACCGTCGAGGGGTTTTAGAATCAC
ATCCCCATGCTGTTCACGGAAGGCTTTAATCTTCTCGGCTTTGCGCGTCACCATAGTGATCGGCGTCAGC
TCTGGGAACCAAGCGGTGAACAGTTTTTCATTACAATCGCGCAGGCTTTGTGGTTTGTTCACCACTAATA
CGCCTTCATCTTCCGCGCGCTCCAAAATGTAGGTTGCGTAGATGTATTCGGTGTCGAACGGCGGATCCTT
ACGCATTAAAATCGCATCCAATTCAGAAAGTGCGATGGTTTGCTCAGATTTGAATTGGTACCAACCGCTC
GGATCTTCTTTCAGCTCGACAACTTTAGTATCGGCCAGTGCTACACCTTGCTCTAAGTGTAGATCATTCA
TCTCCATATAATGGATTTCATAACCGCGACGCTGCGCTTCAAGCATCATGGCAAAGCTGGAATCTTTTTT
GATGTTAATGGACGCGATAGGGTCCATCACAATACCGAGTTTAATCA
Protein Sequence 
>gi|15640495|ref|NP_230122.1| glutathione synthetase [Vibrio cholerae O1 biovar El Tor str. N16961]
MIKLGIVMDPIASINIKKDSSFAMMLEAQRRGYEIHYMEMNDLHLEQGVALADTKVVELKEDPSGWYQFK
SEQTIALSELDAILMRKDPPFDTEYIYATYILERAEDEGVLVVNKPQSLRDCNEKLFTAWFPELTPITMV
TRKAEKIKAFREQHGDVILKPLDGMGGASIFRVKEGDPNLSVIIETLTNHGQNYCMAQTFVPDISNGDKR
ILVVDGEPMPYCLARIPAKGETRGNLAAGGRGEPRPLSETDKKIALAVAPTLKEKGLLFVGLDVIGDKLT
EINVTSPTCIREIEAAYDISITGKLMDAIERRLKATAM
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0468 mutant is attenuated in mice (Merrell et al., 2002).
COG COG0189HJ, under H: Coenzyme transport and metabolism; J: Translation, ribosomal structure and biogenesis
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].