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VC0243

Victor ID 2454
Gene Name VC0243
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2614706
NCBI Protein GI 15640273
Locus Tag VC0243
Genbank Accession AE003852
Protein Accession NP_229900
Other Database IDs UniProtKB-ID: GM4D1_VIBCH
UniRef100: UniRef100_Q06952
UniRef90: UniRef90_Q06952
UniRef50: UniRef50_O60547
UniParc: UPI000012B8A6
EMBL: X59554
EMBL: AE003852
EMBL-CDS: CAA42136.1
EMBL-CDS: AAF93419.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC0243
TIGR: VC_0243
HOGENOM: HBG755066
OMA: TQRVDHI
ProtClustDB: CLSK793536
BioCyc: MetaCyc:MONOMER-13574
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 249322
Gene Ending Position 250443
Gene Strand (Orientation) +
Protein Name GDP-mannose 4,6-dehydratase
Protein pI 5.87
Protein Weight 38977.48
Protein Length 373
Protein Note similar to GB:X59554 PID:48385; identified by sequence similarity; putative
DNA Sequence 
>gi|15640032:249322-250443 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
AATGAATAAAAAAGTTGCGTTAATCACAGGCATTACTGGACAAGATGGTTCTTATCTAGCGGAGTTTTTG
CTAGAAAAAGGGTATGAAGTACATGGAATTAAAAGACGTTCATCTTTATTCAATACACAACGTGTTGATC
ATCTTTACAAAGACCCACATGAGGAAGATGTAAATTTCAAACTACATTACGGAGACCTTACGGATTCCTC
TAACTTGACTCGTATATTAGCGGAAGTACAGCCAGATGAAGTCTATAACTTGGGCGCGCAGTCCCATGTG
GCGGTTAGTTTCCAGTCACCGGAATATACAGCGGACGTAGATGCTATTGGAACTTTAAGGCTACTAGAAG
CAATCAGATTTTTAGGTTTGACGAAAAAAACTAAGTTTTATCAAGCCTCAACTTCAGAGCTTTATGGCTT
AGTACAAGAAATACCTCAGAAAGAAACTACCCCTTTTTATCCTAGAAGCCCTTATGCTGTGGCAAAGATG
TATGCGTATTGGATAACAATTAATTATAGAGAATCGTACGGAATATACGCGTGTAATGGCATACTTTTTA
ACCACGAATCCCCTAGACGAGGAGAAACTTTTGTAACTCGCAAAATAACTCGGGGGATGGCAAACATTGC
GCAAGGGTTAGAAAAATGCCTTTTTATGGGAAATTTGGACGCTCTTCGAGATTGGGGGCATGCTAAAGAT
TACGTTAAGATGCAATGGATGATGTTACAGCAAGATGAACCTAGAGATTTTGTTATTGCTACAGGTGTAC
AGTATAGCGTAAGAGAGTTTATTGATATGTCAGCACGAGAACTAGGCATTGAGTTAGAATTTGTCGGTAA
GGGTGTAGATGAAAAAGCTGTAGTGAAGTCAGTTATTGGAACGAAAGCTCCTGCAATCAAGGTTGGTGAC
ATTATTGTAGCTGTGGATCCTGCATATTTTAGACCCGCAGAGGTAGAAACGCTGTTAGGTGATCCTAGCC
TAGCTAAGAAGGAGCTTGGATGGGTGCCAGAAATTACTTTACAACAGATGGTTTCTGAAATGGTAGCTTC
TGATTTAGAACAAGCTCAAAGTCATGCACTATTGAAAAAACATGGCTATAACGTAAATGTATCTGTAGAG
TG
Protein Sequence 
>gi|15640273|ref|NP_229900.1| GDP-mannose 4,6-dehydratase [Vibrio cholerae O1 biovar El Tor str. N16961]
MNKKVALITGITGQDGSYLAEFLLEKGYEVHGIKRRSSLFNTQRVDHLYKDPHEEDVNFKLHYGDLTDSS
NLTRILAEVQPDEVYNLGAQSHVAVSFQSPEYTADVDAIGTLRLLEAIRFLGLTKKTKFYQASTSELYGL
VQEIPQKETTPFYPRSPYAVAKMYAYWITINYRESYGIYACNGILFNHESPRRGETFVTRKITRGMANIA
QGLEKCLFMGNLDALRDWGHAKDYVKMQWMMLQQDEPRDFVIATGVQYSVREFIDMSARELGIELEFVGK
GVDEKAVVKSVIGTKAPAIKVGDIIVAVDPAYFRPAEVETLLGDPSLAKKELGWVPEITLQQMVSEMVAS
DLEQAQSHALLKKHGYNVNVSVE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0243 mutant is attenuated in mice (Merrell et al., 2002).
COG COG1089M, under M: Cell wall/membrane/envelope biogenesis
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].