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VC0869

Victor ID 2446
Gene Name VC0869
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2614536
NCBI Protein GI 15640885
Locus Tag VC0869
Genbank Accession AE003852
Protein Accession NP_230516
Other Database IDs UniProtKB-ID: PUR4_VIBCH
UniRef100: UniRef100_Q9KTN2
UniRef90: UniRef90_Q9KTN2
UniRef50: UniRef50_Q1R8H7
UniParc: UPI0000132A60
EMBL: AE003852
EMBL-CDS: AAF94031.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC0869
TIGR: VC_0869
HOGENOM: HBG335309
OMA: ERGIAYY
ProtClustDB: PRK05297
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 931848
Gene Ending Position 935741
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamidine synthase
Protein pI 4.89
Protein Weight 133084.93
Protein Length 1297
Protein Note catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
DNA Sequence 
>gi|15640032:931848-935741 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
CATGAGAATTTTGCGTGGCTCCCCAGCTCTTTCAGAGTTTCGTGTTAACAAGCTCCTGACCGCGTGTCGT
GAACAGCAACTGCCTGTAACCGGTATTTACGCCGAGTTTATGCACTTTGCCGATCTCAAGGCAGAGCTCA
ATCCGCAAGAGTTGGAAAAGCTCGAAAAACTGCTCACTTATGGTCCAACCATTCAAGAGCATGAACCGCA
AGGTTTACTGCTGTTGGTGACGCCGCGCCCCGGAACCATCTCACCTTGGTCCTCAAAAGCCACCGATATT
GCACACAACTGTGGCCTGCATGGCATCAAGCGCCTTGAGCGCGGTACGGCTTATTATGTTGAAGCAGAAA
CGGCGCTGACCGCAGCACAAATCGCAACACTTGAGGCGCTGCTGCATGATCGAATGATGGAAGTCGTGTT
CGCAGAACTCACCGATGCCCAGCAACTGTTCAGCGTAGCAGAGCCTGCGCCTATGAGTCAGGTCGATGTA
TTAGCGGGCGGTCGTCGTGCGCTTGAAGAGGCAAACGTTTCCCTTGGTCTGGCATTGGCTGAAGATGAAA
TTGATTATCTGGTTGAGAGCTTCACTAAACTGGGTCGTAATCCTAACGACATTGAACTGATGATGTTTGC
ACAGGCGAACTCAGAGCACTGCCGCCACAAGATTTTCAACGCCGATTGGACCATTGATGGGGTTAAGCAA
GACAAGTCACTGTTCAAAATGATCAAAAACACCTTTGAACAGACGCCGGATTATGTGCTTTCGGCTTATA
AAGATAATGCCGCAGTAATGACGGGCTCGACCGTTGGCCGTTTCTTCCCCGACCCCGAGAGCCGTCAGTA
CACTTATCACCATGAAGATGCCCACATTCTGATGAAAGTGGAAACGCATAACCACCCAACGGCGATTTCG
CCTTGGCCGGGGGCTTCGACTGGTTCTGGCGGTGAAATTCGTGATGAGGGCGCAACCGGTATTGGCGGCA
AGCCTAAAGCGGGATTGGTGGGCTTTACCACCTCGAACTTGCGTATTCCCGGTTTTGAACAGCCATGGGA
AAGCGATTTTGGTAAGCCAAGCCGCATTGTGAATGCGCTGGATATCATGCTGGAAGGGCCACTCGGCGGC
GCGGCGTTCAACAACGAATTTGGTCGCCCGAACCTACTTGGGTATTTCCGCACTTATGAAGAAAAAGTGA
CGTCACATGCTGGTGAAGAGGTGCGTGGTTATCACAAGCCGATCATGATTGCCGGCGGTATGGGTAACAT
TCGCGCCGAGCATATTCAGAAGAAAGAGATCCCAGTGGGGGCAAAACTGATCGTACTCGGAGGCCCTGCG
ATGAACATCGGTCTCGGTGGTGGCGCAGCCTCTTCGATGGCTTCTGGCCAGTCTGCTGAAGATCTGGATT
TTGCTTCTGTGCAGCGTGAAAACCCAGAGATGGAGCGCCGCTGTCAGGAAGTGATTGACCGTTGTTGGCA
GCTCGGTGACAAAAACCCGATCGCCTTTATCCACGATGTGGGCGCGGGTGGTATCTCTAACGCTCTGCCT
GAGCTGGTGAATGACGGCGATCGCGGTGGTAAATTCCAGTTGCGCAACGTGCCGAATGATGAGCCGGGCA
TGAGCCCATTGGAAATCTGGTGTAATGAATCACAAGAGCGTTATGTGCTGGCGGTTGCTGCGGAAGATAT
GCCGCTGTTTGATGCGATTTGCCAGCGTGAACGCGCCCCTTATGCCGTGGTAGGTGAAGCGACCGAAGAG
CGCCATTTGACGCTGGAAGACAGCCACTTTGCTAACACGCCGATTGATATGCCAATGGATATTCTGTTGG
GTAAGCCGCCGAAAATGCATCGTGAAGCGAGCACGCTGAAAGTTTCAAGCCCAGCGCTAGAGCGTTCAGG
CATTGAGCTTAATGAAGCGGTGGATCGCGTACTGCGTTTACCGGCAGTCGCAGAAAAAACGTTCCTGATC
ACCATTGGTGACCGCTCAGTGACTGGCTTAGTCGCGCGGGATCAAATGGTCGGCCCATGGCAAGTTCCCG
TCGCAAACTGCGCAGTAACGGCCGCGAGTTTTGATTCTTACCACGGCGAAGCGATGTCTATGGGTGAGCG
TACCCCTGTTGCGCTGTTGGATTTCGGTGCCTCTGCACGTTTAGCGGTCGGTGAAGCTATTACCAACATA
GCCGCAACCGATATTGGCGAGCTGAAACGCATCAAACTTTCGGCGAACTGGATGTCTCCAGCGGGCCATC
CGGGTGAAGATGCCGGTCTGTATGAAGCGGTGAAAGCGGTCGGTGAAGAGCTTTGTCCTGCACTGGGTAT
CACTATCCCAGTCGGTAAAGACTCGATGTCGATGAAAACCAAGTGGCAGGAAAATGGCGAGCAGAAAGAA
GTGACTTCGCCGCTGTCACTCATCATCACCGCCTTTGCACGTGTGGAAGACATTCGCAAGACCGTGACCC
CACAACTGCGTACTGACCTTGGTGAGACAAGCTTAATCTTGATTGACTTGGGGAATGGTCAAAATCGTCT
TGGCGCAACCGCATTGGCGCAAGTGTACAAACAGTTGGGTGATAAGCCGGCTGATGTGGATAACGCGGCG
CAGCTCAAAGGCTTTTTTGATGCAGTACAAACGCTGGTGCGTAACGACAAGCTGGTGGCTTACCACGACA
AAGGTGACGGCGGTTTATTGGTGACGTTGGCAGAAATGGCTTTCGCGGGTCACTGTGGTATTAAAGCCAA
TATTGAAACCTTGGGTGATGATGCACTGGCGGCACTGTTCAATGAAGAGCTTGGCGCCGTGGTTCAAGTG
AAAAATGATGAGCTGAATGCTGTTCTGGCAACACTTGCCGCCCATGGTTTAGAAGCGTGTGCTCACGTGA
TTGGTGAAGTAGAAGCATCCGATCGTCTGCTGATCACTTGTGGTGAGGAAGTCTTGATTGAGCGCTCTCG
TACTGAGCTTCGCACCATCTGGGCGGAAATGACCCATAAGATGCAAGCGCTGCGTGATAACTCGGCGTGT
GCTGATCAAGAGTTTGCGGCCAAACAAGATAACCGTGACCCGGGCTTGAATGCGAAGTTAACTTACGATG
TGCAAGCCGACGTTGCTGCGCCGTACATCGCCAAAGGTGTGCGTCCGAAAATGGCGATTTTGCGTGAGCA
AGGCGTCAACTCACACGTTGAGATGGCGGCAGCGTTTGACCGCGCTGGTTTTGATGCGGTTGATGTGCAT
ATGAGCGACATTCTGACTGGGCAAACCGTGCTCGATGCTTACCAAGGTCTGGTGGCTTGTGGTGGCTTCT
CTTACGGCGACGTACTGGGTGCGGGCGAAGGTTGGGCGAAATCGATTCTGTTTAACGCCCAAGCGCGTGA
GCAGTTTGAGCAGTTCTTCCAACGTAAAGATACTTTCTCACTTGGGGTGTGTAACGGCTGTCAAATGCTG
TCTAACCTGCGTGATTTGATCCCGGGTGCTGAGCTATGGCCACGTTTTGTGCGTAACGAATCGGATCGTT
TTGAAGCGCGCTTTAGCTTAGTCGAAGTGCAAAAATCGCCATCGCTGTTCTTTAGCGAGATGGCGGGCTC
AAGAATGCCGATTGCGGTTTCTCATGGTGAAGGTCGTGTGGAAGTGCGTGATGCTCAGCATCTGGCGGCA
ATTGAGCAATCTGGCACCGTAGCGATTCGTTTCGTGGATAACTTTGGTCAGCCAACCCAAGCTTACCCAA
GCAACCCGAACGGTTCACCGAATGCGATTACCGGTTTAACCACTCAAGATGGCCGTGTGACGATTATGAT
GCCGCACCCTGAGCGTGTATTCCGTACCGTCGCCAACTCGTGGCACCCTGATAACTGGGGTGAGAATGGC
GCTTGGATGCGTATGTTCCAGAATGCTCGTAAATATTTTGGCTA
Protein Sequence 
>gi|15640885|ref|NP_230516.1| phosphoribosylformylglycinamidine synthase [Vibrio cholerae O1 biovar El Tor str. N16961]
MRILRGSPALSEFRVNKLLTACREQQLPVTGIYAEFMHFADLKAELNPQELEKLEKLLTYGPTIQEHEPQ
GLLLLVTPRPGTISPWSSKATDIAHNCGLHGIKRLERGTAYYVEAETALTAAQIATLEALLHDRMMEVVF
AELTDAQQLFSVAEPAPMSQVDVLAGGRRALEEANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFA
QANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPESRQY
TYHHEDAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWE
SDFGKPSRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSHAGEEVRGYHKPIMIAGGMGNI
RAEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQ
LGDKNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDM
PLFDAICQRERAPYAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKMHREASTLKVSSPALERSG
IELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYHGEAMSMGER
TPVALLDFGASARLAVGEAITNIAATDIGELKRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGI
TIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRL
GATALAQVYKQLGDKPADVDNAAQLKGFFDAVQTLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKAN
IETLGDDALAALFNEELGAVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLITCGEEVLIERSR
TELRTIWAEMTHKMQALRDNSACADQEFAAKQDNRDPGLNAKLTYDVQADVAAPYIAKGVRPKMAILREQ
GVNSHVEMAAAFDRAGFDAVDVHMSDILTGQTVLDAYQGLVACGGFSYGDVLGAGEGWAKSILFNAQARE
QFEQFFQRKDTFSLGVCNGCQMLSNLRDLIPGAELWPRFVRNESDRFEARFSLVEVQKSPSLFFSEMAGS
RMPIAVSHGEGRVEVRDAQHLAAIEQSGTVAIRFVDNFGQPTQAYPSNPNGSPNAITGLTTQDGRVTIMM
PHPERVFRTVANSWHPDNWGENGAWMRMFQNARKYFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0869 mutant is attenuated in mice (Merrell et al., 2002).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].