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VC0051

Victor ID 2437
Gene Name VC0051
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2614419
NCBI Protein GI 15640083
Locus Tag VC0051
Genbank Accession AE003852
Protein Accession NP_229710
Other Database IDs UniProtKB-ID: PURK_VIBCH
UniRef100: UniRef100_Q9KVT8
UniRef90: UniRef90_Q9KVT8
UniRef50: UniRef50_Q7MGL1
UniParc: UPI00000C2BAB
EMBL: AE003852
EMBL-CDS: AAF93229.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC0051
TIGR: VC_0051
HOGENOM: HBG516369
OMA: LAVEMFV
ProtClustDB: PRK06019
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 48323
Gene Ending Position 49456
Gene Strand (Orientation) -
Protein Name phosphoribosylaminoimidazole carboxylase ATPase subunit
Protein pI 5.76
Protein Weight 37641.06
Protein Length 377
Protein Note With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
DNA Sequence 
>gi|15640032:48323-49456 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
ATTAAGGCTGAATTTCCTTTGCTACGGCGTGTACGGCAGGAAAAGCCTTTTCATCTAACACAGTCGCTAA
TTGGCATAATTTGCGTTGCAACTCACCACTGTAATCGGCGGTCACATTGATATGCCCCATCTTGCGTCCT
GAGCGCTTGGCCTTGCCGTACCAATGTACGTGGCAGCCTTCCAGTGCCAATACTTCTGCGGGCAGCTGAT
CTTCACCAAGAATATTAATCATCGCGGTCTCACGAACCAGTTTGGTGCTACCCAGCGGTAAGCCACACAC
TGCGCGTAAGTGGTTTTCGAACTGACAGGTTTCCGCACCTTGCTGAGTCCAGTGACCGGAGTTATGAACT
CGTGGTGCAATTTCATTGACCAGTAACTGGCCTTGTACTTCAAAAAACTCCAGCGCTAATACACCGACAT
AATTGAGCTGCTCGGCTACCGCTTTAAACATGGCTTTCGCTTGAGTTTGTAGCGCAGGAGCATCAATGGC
GGTAGAAAGGCTCAACACACCTTGGGTATGAACGTTCTCCGCTAAAGGATACACCACAACATCGCCGACT
AGGTTACGTGCACCGACCAGTGACACTTCGCGATCAAAAGCGACAAATTCTTCTGCCACAATTGCTTGTT
CGGGGTTGGCTGCCAGATATTGCGCAAGTTCTTGCCAAACCGATTCGATCTGCGTTGGTTCTTTCAAGCG
CCATTGGCCTTTTCCATCGTAGCCTCCGAGTGCACTTTTCAGCACCATAGGCAATCCAATCTCGGCGATG
GCTGAGGTTAGGTCGTCTCGGCTGCGGATCATCGTATAACGTGCATTCGCCACTTGGGCGCGATCCAGCA
AGGCTTTTTCTAAACGACGATCGCCGCCAGCTTTGATAGCTTCAGCGCTTGGGTAAAGTTTGCCACTGCG
TGCACAGAGATCGAGGATCGGATGCGGAATGTGTTCAAACTCAGCGGTGATCACATCGACTTGTTCAATC
GCTTGCTCCAATCCATGCCCAAGCACAGTTTGCGTTAAGGGGTGCACAATGTTTTCGCTACCCACATCAA
AAGCGATCGTTTCAATATTGAGCGGTGCTCCGGCGAGCGACATCATGCGCGCCAGCTGACCAGCGCCGAG
AACCAACACACGCA
Protein Sequence 
>gi|15640083|ref|NP_229710.1| phosphoribosylaminoimidazole carboxylase ATPase subunit [Vibrio cholerae O1 biovar El Tor str. N16961]
MRVLVLGAGQLARMMSLAGAPLNIETIAFDVGSENIVHPLTQTVLGHGLEQAIEQVDVITAEFEHIPHPI
LDLCARSGKLYPSAEAIKAGGDRRLEKALLDRAQVANARYTMIRSRDDLTSAIAEIGLPMVLKSALGGYD
GKGQWRLKEPTQIESVWQELAQYLAANPEQAIVAEEFVAFDREVSLVGARNLVGDVVVYPLAENVHTQGV
LSLSTAIDAPALQTQAKAMFKAVAEQLNYVGVLALEFFEVQGQLLVNEIAPRVHNSGHWTQQGAETCQFE
NHLRAVCGLPLGSTKLVRETAMINILGEDQLPAEVLALEGCHVHWYGKAKRSGRKMGHINVTADYSGELQ
RKLCQLATVLDEKAFPAVHAVAKEIQP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0051 mutant is attenuated in mice (Merrell et al., 2002).
COG COG0026F, under F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].