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VC2030

Victor ID 2413
Gene Name VC2030
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2613409
NCBI Protein GI 15642032
Locus Tag VC2030
Genbank Accession AE003852
Protein Accession NP_231664
Other Database IDs UniProtKB-ID: Q9KQG8_VIBCH
UniRef100: UniRef100_C3LNY1
UniRef90: UniRef90_C3LNY1
UniRef50: UniRef50_P21513
UniParc: UPI00000C31A6
EMBL: AE003852
EMBL-CDS: AAF95178.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC2030
TIGR: VC_2030
HOGENOM: HBG756312
OMA: AVEPEIT
ProtClustDB: CLSK874643
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2181443
Gene Ending Position 2184601
Gene Strand (Orientation) +
Protein Name ribonuclease E
Protein pI 7.53
Protein Weight 108397.66
Protein Length 1052
Protein Note similar to SP:P21513 GB:X67470 GB:L23942 GB:M62747 GB:X54309; identified by sequence similarity; putative
DNA Sequence 
>gi|15640032:2181443-2184601 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
AATGAAAAGAATGTTAATTAACGCAACTCAAAAAGAAGAGTTGCGTGTCGCGTTGGTCGATGGCCAACGT
CTGTTCGATCTGGATATTGAAAGTCCGGGGCACGAATCGAAAAAAGCAAATATCTACAAAGGCCGCATTA
CCCGCATTGAACCCAGTCTTGAAGCTGCATTCGTTGACTACGGTGCTGAAAGACACGGTTTCCTCCCTCT
CAAAGAAATCGCTCGTGAATACTTCCCTGATGGTTATAGCTACCAAGGTCGTCCAAACATCAAAGATGTG
CTGAACGAAGGTCAGGAAGTGATCGTGCAAATCGAGAAAGAGGAGCGCGGTAGCAAAGGTGCAGCCCTAA
CCACCTTTATCTCTCTAGCGGGCAGCTACTTAGTTCTGATGCCAAATAACCCTCGTGCTGGCGGTATTTC
TCGTCGTATCGAAGGCGATGAGCGCACTGAACTGAAATCAGCACTCAGCTCACTAGAATTGCCACAAGGT
ATGGGCTTAATTGTTCGTACCGCAGGCGTAGGTAAAAGCGCTGAAGAGCTAGAGTGGGACTTAAATGTAC
TGCTTAAGCACTGGAGTGCGATTAAACAAGCGTCTGATTCAAACCCTGCACCTTTCCTTATCCACCAAGA
AAGTAACGTGATTGTTCGTGCGATCCGTGATTACTTGCGTCGTGATATTGGTGAAATTCTTATCGACAGC
AACAGCATTTACGAGCGTGCTCTTGAGCATATCCGTTTAGTGCGCCCAGATTTCGTCAATCGTGTGAAAA
AATACGAAGGCGAAGTACCGCTGTTCAGCCATTTCCAAATCGAAAGCCAGATTGAATCGGCTTTCCAACG
TGAAGTTCGCCTGCCTTCTGGTGGTTCAATCGTTATTGACCCAACCGAAGCCTTGACTTCCATCGACATC
AACTCTGCTCGCGCAACCAAAGGTGGCGATATTGAAGAGACCGCTCTCAATACCAACCTAGAAGCTGCAG
ATGAAATCGCACGCCAATTGCGTCTGCGTGACCTCGGTGGTCTTGTGGTGATCGACTTCATCGATATGAC
CCCTGTTCGCCACCAGCGTGAAGTGGAAAACCGTCTACGTGAAGCGGTGCGTGTTGACCGTGCTCGCGTT
CAAATTGGCCGTATTTCTCGCTTTGGTTTGCTGGAGATGTCGCGTCAACGTTTGAGCCCTTCTCTGGCAG
AAGCAAGCCATCACATCTGTCCTCGTTGTAAAGGAACCGGCGTGATTCGTGACAACGAATCTTTGGCACT
TTCTGTTCTGCGCTTAATTGAAGAAGAAGCACTCAAAGACAACACATCGCAAGTGCTTGCGGTGGTACCT
GTCTCTATCGCGTCTTATCTGTTAAACGAGAAGCGTCGCTCAATCAATCACATTGAAAAAGCGCAGCAAG
TTCGCATTACTATCGTGCCAAATTCCGATATGGAAACACCGCACTTTGAAGTGATCCGCGTGCGTGAAGG
TGAAGAGCAAGATGTTCTCTCTTACCTGATTCCGAAAAAGCTGGAAGCGATGAAAGAAGCGGAAGGCAAA
GAAGTGGTCGATGTTGAGCTCAAACCAAAACGTATTGAAGAGCCAGTACTGAAAGGTTTTGCAGCGCCTG
CGGAAGCGGTTCCTGCTCCAACACCAAAACCTAAAGCAGAACCTCAACCTGTTGCAGAGGTACAGCAACC
TGCGCAGCCTGGTTTCTTTAGCCGTGTGTTTAAAGCGATTGCGAGCCTATTCTCTGCGACACCGGAAGCG
GCCAAAGTAGAAGCGCCTGTAACGCAGAATAGTGAACAAGACAAACCTCGTCGTGAACGTAACGATCGTA
ATAATGATCGTCGTCGTAACCCTCGTGACAAAAACCGTCGCCGCGGTAATGAGGAAAACAACGAGCGTAA
CGATAAAGAGACATCAAACAGCAACCGTAAGCCACAAGAGCGCAAGCCAAAGCAAGAGCGTGGTGAGCGT
AACGAACGTAATGACCGCAATGAACGTCCAGAAACCGAGCGTCCAGAACGTCAAGATCGTCGTAATAAAC
GAGATGAAAGTAAAACGGCTAAATTGCTTGAGCAAGGTCGCCAATTAGCGGCTGAAGCACAACAAGAAGT
TAAAGCCGTTGAGCCTAAAGAAGAGAAAGCCGCGGTTGTTAAAGAACGTCGTCAACGTCGTAAGCTCTCG
AAGCAAATTCGAGTCAAAGATCAGCTTGCCGCAGAAGAGTTAGACAACCTGTCTACAGCTCCTGTTGACA
ATGCGTTCGACGCTCCAGCGCCAGTTAATCTGCCTGTAACCGATGATTTTGCGGATTCGGCTCAAGAGGA
TAACGAGCAAGATGATCAGAAGCAGCGTCGTAATCGCCGCTCGCCACGTCATCTGCGCGCCAGCGGCCAG
CGCCGCCGTCGTGGTCGTGATCGTCGCCCTAACCCATTCCGCCTGCGTAAAGGTGGGGTTGCCTCTCCTG
AGATGGCCATGGGTAAAGTGATGCCTCGCTACGACTTAGCGCCGCGTCCACAGTCACGCCATGAAACTGC
TGAAGGTGCTCAACATGTGACTCATGTAACACCGACTGCGGCAACTGCAGTAGTAGAAAGCGAAAAAGTG
GCAGCGCCACGTGTACTCGGAGGCGTTGCCTTCCCAGAAATGGCGATGGGTAAAGTCATCGTACGTCGTG
AAACTGCTGCGGTTCAACCTGAGCCAGTAGTGCAAGAGCCAGTGATTACTGACGTGATCGCAGAGACACT
CATCGCACCCGTTGAGCCGGTCGTGGTTGAAGCTACAGTGATTGAAGCTCCGGTAATTGAAGAGTCAGCA
ACAGAAACTGCTGCGCTAGAAACCGTAGTGGCGAAAGTCGCTGAAGTCGAAGAGCCAGCCACAATCAGTG
ACGAGGTTGTCGCACAAACGACGGTTGAAGTGATCGCAGACAAAATGGCAGAACCAATTAAGGTTGTTAA
GCCAGTGACAGTGAGTGCAACATCACTCACCGCGAAAGCGGTCATCCAACAGCCGTACGCCTCATCGCCG
ATGACTAAAGCACCTGGCTCAGATGACATCCGTGAAGTGCAGGTTAACGCCGCGCCTTTACGTGCTGAAC
GTTACCAAGCGCGTGGTGCGGGTAGTCAAGTCGCGCGTAATCAAGCCAGTGCGGGCATGAGTAAGCCGCA
AAGCTTCTA
Protein Sequence 
>gi|15642032|ref|NP_231664.1| ribonuclease E [Vibrio cholerae O1 biovar El Tor str. N16961]
MKRMLINATQKEELRVALVDGQRLFDLDIESPGHESKKANIYKGRITRIEPSLEAAFVDYGAERHGFLPL
KEIAREYFPDGYSYQGRPNIKDVLNEGQEVIVQIEKEERGSKGAALTTFISLAGSYLVLMPNNPRAGGIS
RRIEGDERTELKSALSSLELPQGMGLIVRTAGVGKSAEELEWDLNVLLKHWSAIKQASDSNPAPFLIHQE
SNVIVRAIRDYLRRDIGEILIDSNSIYERALEHIRLVRPDFVNRVKKYEGEVPLFSHFQIESQIESAFQR
EVRLPSGGSIVIDPTEALTSIDINSARATKGGDIEETALNTNLEAADEIARQLRLRDLGGLVVIDFIDMT
PVRHQREVENRLREAVRVDRARVQIGRISRFGLLEMSRQRLSPSLAEASHHICPRCKGTGVIRDNESLAL
SVLRLIEEEALKDNTSQVLAVVPVSIASYLLNEKRRSINHIEKAQQVRITIVPNSDMETPHFEVIRVREG
EEQDVLSYLIPKKLEAMKEAEGKEVVDVELKPKRIEEPVLKGFAAPAEAVPAPTPKPKAEPQPVAEVQQP
AQPGFFSRVFKAIASLFSATPEAAKVEAPVTQNSEQDKPRRERNDRNNDRRRNPRDKNRRRGNEENNERN
DKETSNSNRKPQERKPKQERGERNERNDRNERPETERPERQDRRNKRDESKTAKLLEQGRQLAAEAQQEV
KAVEPKEEKAAVVKERRQRRKLSKQIRVKDQLAAEELDNLSTAPVDNAFDAPAPVNLPVTDDFADSAQED
NEQDDQKQRRNRRSPRHLRASGQRRRRGRDRRPNPFRLRKGGVASPEMAMGKVMPRYDLAPRPQSRHETA
EGAQHVTHVTPTAATAVVESEKVAAPRVLGGVAFPEMAMGKVIVRRETAAVQPEPVVQEPVITDVIAETL
IAPVEPVVVEATVIEAPVIEESATETAALETVVAKVAEVEEPATISDEVVAQTTVEVIADKMAEPIKVVK
PVTVSATSLTAKAVIQQPYASSPMTKAPGSDDIREVQVNAAPLRAERYQARGAGSQVARNQASAGMSKPQ
SF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC2030 mutant is attenuated in mice (Merrell et al., 2002).
COG COG1530J, under J: Translation, ribosomal structure and biogenesis
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].