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VC2291

Victor ID 2409
Gene Name VC2291
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2613213
NCBI Protein GI 15642289
Locus Tag VC2291
Genbank Accession AE003852
Protein Accession NP_231922
Other Database IDs UniProtKB-ID: NQRE_VIBCH
UniRef100: UniRef100_A5F5Y5
UniRef90: UniRef90_B6EIC7
UniRef50: UniRef50_Q487D7
UniParc: UPI000013045F
EMBL: AF117331
EMBL: AE003852
EMBL-CDS: AAD29966.1
EMBL-CDS: AAF95435.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC2291
TIGR: VC_2291
HOGENOM: HBG624915
OMA: FLGMCSF
ProtClustDB: PRK02830
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2446182
Gene Ending Position 2446778
Gene Strand (Orientation) -
Protein Name Na(+)-translocating NADH-quinone reductase subunit E
Protein pI 7.25
Protein Weight 19188.4
Protein Length 198
Protein Note Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
DNA Sequence 
>gi|15640032:2446182-2446778 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
CTTACAGTTGAACACCAGAGAAAGACATGAAGCCCAACGCCATCAAGCCAGCCGTGATAAAGGTAATACC
TAAACCACGCAGACCTGGAGGAACGTCTGAATACTTCATCTTCTCACGGATACCTGCAAGAGCGACGATA
GCCAGCATCCAACCCACACCAGAACCGAAACCGTATACCACTGATTCAGCAAAGCTGTAGTCGCGCTGCA
CCATGAAAGACACACCACCGAAGATCGCACAGTTTACTGTGATCAGCGGAAGGAAGATGCCCAGTGCGTT
ATACAGAGGCGGGAAGAAGCGATCGAGGATCATTTCCAGAATCTGTACTAATGCCGCAATAACACCGATA
AAGGTAATAAAGTTGAGGAAGCTAAGATCTACCCCTTCAACCAGTGCATCTGGCTTAAGCACAAGGTTGT
ACACCAGATTGTTAACTGGTACAGAGATAGTCAGTACTACGATTACCGCAATACCTAAGCCGAATGATGT
CTTAACTTTCTTCGACACCGCCAAGAATGTACACATCCCTAGGAAGAAAGAGAGTGCCATGTTCTCGATG
AAAATCGATTTCACCAGCAGACTAATATAATGTTCCA
Protein Sequence 
>gi|15642289|ref|NP_231922.1| Na(+)-translocating NADH-quinone reductase subunit E [Vibrio cholerae O1 biovar El Tor str. N16961]
MEHYISLLVKSIFIENMALSFFLGMCTFLAVSKKVKTSFGLGIAVIVVLTISVPVNNLVYNLVLKPDALV
EGVDLSFLNFITFIGVIAALVQILEMILDRFFPPLYNALGIFLPLITVNCAIFGGVSFMVQRDYSFAESV
VYGFGSGVGWMLAIVALAGIREKMKYSDVPPGLRGLGITFITAGLMALGFMSFSGVQL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC2291 mutant is attenuated in mice (Merrell et al., 2002).
COG COG2209C, under C: Energy production and conversion
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].