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carB from Vibrio cholerae O1 biovar El Tor str. N16961

Victor ID 2403
Gene Name carB from Vibrio cholerae O1 biovar El Tor str. N16961
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2613058
NCBI Protein GI 15642386
Locus Tag VC2389
Protein Accession NP_232019.1
Other Database IDs UniProtKB-ID: CARB_VIBCH
UniRef100: UniRef100_Q9KPH9
UniRef90: UniRef90_Q7MNU0
UniRef50: UniRef50_Q9ZKT2
UniParc: UPI0000126FA7
EMBL: AE003852
EMBL-CDS: AAF95532.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC2389
TIGR: VC_2389
HOGENOM: HBG405439
OMA: EFATNTA
ProtClustDB: PRK05294
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2554048
Gene Ending Position 2557278
Gene Strand (Orientation) -
Protein Name carbamoyl phosphate synthase large subunit
DNA Sequence 
>gi|15640032:2554048-2557278 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
ATTAAGCTTGGTTCGCTTTTACACGCGCATGCAGCTCTTGTACTGAAGTGACGGATGCTTTGGCATCCGC
CGTGTGTGACATACAAGTTGCGAAGGCGGCGTTCAGTGTGGTGGTGTAGTTCACTTTGTGAGCCAATGCA
CCACGGCGCAGTACTTTTGAGTCTTCAATTGCTTGGCGGCCAGAAGCCGTGTTCACAATGTAGGTGTACT
CGTGGTTTTTGATGCGATCCAGAATGTGTGGACGACCTTCATGCACTTTGTTAACCAGACGTGGGTTGAT
GCCCGCTTCGCCCAGAATCACTGCAGTACCGTGAGTCGCATCCAACTGGTAACCCAGTTTCACTAGCTTA
GAAGCCAGATCCACTACACGCTGTTTGTCACCTTCACGCACCGAAAGTAGCGCACGACCACCTTCAGGGT
AAACCGAGCCACAGCCCAACTCTGCTTTAGCATAGGCTTCAGCAAACGTGGCACCCACACCCATCACTTC
ACCGGTTGAGCGCATTTCAGGGCCAAGCAGTGGGTCAACCCCCGGGAACTTGTTGAACGGCAGAACCACT
TCTTTAACTGAGTAGTAAGGTGGAATGATCTCTTTGGTGAAGCCTTGTTGCTCCAGAGTTTGTCCAACCA
TCACGCGCGCCGCGATTTTCGCCAGCGGAGCACCGGTTGCTTTAGAAACAAACGGCACAGTACGCGCAGC
ACGTGGGTTTACTTCAATCAGGTAAACTTCGTTGTCTTTGACTGCAAACTGAATGTTCATCAGGCCACGA
ACACCGAGTTCAAATGCCAACTTCTCAACTTGCTCACGCATCTTGTCTTGGATTTCTTGGCTCAAGGTGT
AAGCCGGCAGAGAACAGGCTGAGTCACCTGAGTGAACACCCGCTTGTTCAATGTGCTCCATGATGCCGCC
AATCACCACGCGCTCACCGTCACAAATCGCATCCACGTCCACTTCGGTTGCATCATCAAGGAAGCGATCC
AGCAGAACTGGTGATTCATTCGACACGCTCACCGCTTCGTTGAAGTAACGACGCAGATCTTGCTCATCGT
ACACAATCTCCATCGCACGGCCACCCAGAACATAAGAGGGGCGAACTACGAGTGGGAAACCGATTTCACG
CGACTTCTCAATCGCTTGCTCGATAGCGGTTACGGTTGCGTTGTCTGGCTGTTTGAGGCCTAAACGCTGT
ACCGCTTGTTGGAAACGTTCACGGTCTTCAGCGCGGTCAATCGCATCTGGGCTGGTACCAATCACAGGTA
CGCCAGCCGCTTCCAGCGCTCGCGCCAGTTTCAGTGGTGTTTGACCGCCGTACTGCACGATCACGCCTTT
TGGCTTCTCAACACGCACGATAGCCAGCACATCCTCTAGAGTTACAGGCTCAAAGTAGAGGCGATCTGAG
GTGTCGTAATCGGTTGATACGGTTTCTGGGTTACAGTTAACCATGATGGTTTCGTAACCATCTTCACGCA
GTGCAAGCGCGGCGTGTACACAGCAGTAGTCAAACTCGATACCTTGACCGATACGGTTTGGACCACCGCC
CAGCACCATGATCTTGTCTTTGTCAGTCGGATTGGCTTCACACTCTTCATCATACGTGGAGTACATGTAA
GCCGTATCTGACTTAAATTCTGCCGCGCAGGTATCCACACGCTTGTAAACTGGGTGGATGTTGTATTGGT
CACGCAGACGACGGATTTCGTTTTCGCTCACGCCGAGCAGTTTTGACAAACGCGCATCAGAGAAGCCTTT
GCGCTTCATCTTACGCAGTACGTCTTGGTTCAAGCCCGCAAAGCCACCGGCTTTCACTTCGGCTTCCAGC
TTCACCAGTTCTTCAATTTGCACTAGGAACCAGCGATCGATGTTGGTCAGGTTAAATACCCCATCCACTG
ACATACCGGCACGGAATGCATCCGCGATGTACCAAATACGCTCTGCGCCTGCTTCTTTCAGCTCATAACG
AATTTTGGTCAGAGCGTCTGGCGCGTCCAGATCCACTTTCTCATCCAGACCAGCCGCACCCACTTCCAAG
CCGCGCAGTGCTTTTTGCAGTGATTCTTGTTGGTTACGACCAATCGCCATCACCTCACCTACTGACTTCA
TTTGTGTAGTCAGACGGTCATTGGCACCGGCGAATTTTTCGAAGTTGAAACGAGGGATCTTAGTGACCAC
GTAGTCGATGGTCGGTTCGAACGAGGCTGGTGTTGCGCCGCCTGTGATGTCGTTCATCAACTCATCCAGA
GTGAAACCCACTGCCAGTTTGGCCGCCACTTTCGCAATTGGGAAACCGGTGGCTTTTGAAGCCAACGCAG
AAGAGCGCGATACACGTGGATTCATCTCGATGATCACCATGCGGCCATCTTTCGGGTTGATACCAAACTG
AACGTTTGAACCGCCGGTTTCTACGCCGATTTCACGCAGTACCGCCAAAGAGGCGTTACGCATGATTTGG
TATTCTTTGTCAGTTAGCGTTTGCGCTGGAGCGACAGTGATCGAGTCACCCGTGTGGATGCCCATTGGGT
CGAAGTTTTCAATCGCACAGACGATGATGCAGTTATCGTTCTTATCACGCACCACTTCCATCTCGTACTC
TTTCCAACCAATCAGTGATTCATCGATCAGCAGTTCATTGGTCGGTGAAAGATCCAGACCGCGAGTACAG
ATTTCTTCAAACTCTTCACGGTTGTAAGCGATACCACCACCGCTGCCGCCCATGGTGAAAGAAGGACGGA
TGATACATGGGAAGCCAACCATATCGAGGACTTTGTACGCTTCTTCCATGCTTTTTGCGGTATCAGCGCG
AGGACACTCTAGGCCGATTGATTTCATCGCTTTATCAAAGCGTGAGCGGTCTTCCGCTTTATCAATCGCA
TCGGCGGTTGCGCCGATCATCTCAACGCCAAACTCAGCCAATACGCCATGTTTTTCGAGTGCCAGCGCAC
AGTTCAGCGCAGTCTGGCCGCCCATGGTGGGCAAAATCGCATCTGGGCGCTCTTTTTCGATGATCTTACG
CACCACTTCCCAGTGGATAGGCTCGATGTAAGTCGCATCGGCCATTTCTGGGTCAGTCATGATGGTCGCT
GGGTTTGAGTTAACCAGAATAACGCGGTAACCCTCTTCGCGCAGGGCTTTACACGCTTGCGCGCCTGAGT
AGTCAAACTCACAAGCCTGACCGATAACAATTGGACCCGCACCAAGGATAAGGATGCTTTGAATGTCAGT
ACGTTTTGGCA
Protein Sequence 
>gi|15642386|ref|NP_232019.1| carbamoyl phosphate synthase large subunit [Vibrio cholerae O1 biovar El Tor str. N16961] MPKRTDIQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAILPTMGGQTALNCALALEKHGVLAEFGVEMIGATADAIDKAEDRSRFDKAMKSIGLECPRADTAKSMEEAYKVLDMVGFPCIIRPSFTMGGSGGGIAYNREEFEEICTRGLDLSPTNELLIDESLIGWKEYEMEVVRDKNDNCIIVCAIENFDPMGIHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVETGGSNVQFGINPKDGRMVIIEMNPRVSRSSALASKATGFPIAKVAAKLAVGFTLDELMNDITGGATPASFEPTIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNQQESLQKALRGLEVGAAGLDEKVDLDAPDALTKIRYELKEAGAERIWYIADAFRAGMSVDGVFNLTNIDRWFLVQIEELVKLEAEVKAGGFAGLNQDVLRKMKRKGFSDARLSKLLGVSENEIRRLRDQYNIHPVYKRVDTCAAEFKSDTAYMYSTYDEECEANPTDKDKIMVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLAIVRVEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQQAVQRLGLKQPDNATVTAIEQAIEKSREIGFPLVVRPSYVLGGRAMEIVYDEQDLRRYFNEAVSVSNESPVLLDRFLDDATEVDVDAICDGERVVIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDKMREQVEKLAFELGVRGLMNIQFAVKDNEVYLIEVNPRAARTVPFVSKATGAPLAKIAARVMVGQTLEQQGFTKEIIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGATFAEAYAKAELGCGSVYPEGGRALLSVREGDKQRVVDLASKLVKLGYQLDATHGTAVILGEAGINPRLVNKVHEGRPHILDRIKNHEYTYIVNTASGRQAIEDSKVLRRGALAHKVNYTTTLNAAFATCMSHTADAKASVTSVQELHARVKANQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: carB mutant is attenuated in mice (Merrell et al., 2002).
COG COG0458EF, under E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].