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VC2453

Victor ID 2399
Gene Name VC2453
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2612995
NCBI Protein GI 15642449
Locus Tag VC2453
Genbank Accession AE003852
Protein Accession NP_232082
Other Database IDs UniProtKB-ID: Q9KPC0_VIBCH
UniRef100: UniRef100_C3LQZ6
UniRef90: UniRef90_A5F5I9
UniRef50: UniRef50_P59342
UniParc: UPI00000C32DB
EMBL: AE003852
EMBL-CDS: AAF95595.1
RefSeq_NT: NC_002505.1
HSSP: Q9A5I4
GenomeReviews: AE003852_GR
KEGG: vch:VC2453
TIGR: VC_2453
HOGENOM: HBG298668
OMA: VESAANQ
ProtClustDB: PRK11107
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2634596
Gene Ending Position 2637379
Gene Strand (Orientation) +
Protein Name hybrid sensory histidine kinase BarA
Protein pI 6.05
Protein Weight 97219.14
Protein Length 927
Protein Note part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
DNA Sequence 
>gi|15640032:2634596-2637379 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
AATGACTCAAAGATATGGCTTGCGCGCCCGCGTTATGACGCTCACTTTGGCACCTACCCTGATTATTGGT
CTGCTGCTTAGCGCTCTGTTCTCTTTTAACCGTTATCACGATTTAGAAACTCAAGTGATCAATTCCGGTG
CCAGCATCATTGAGCCATTAGCGATCGCCAGTGAAGATGCGCTGCGTATGCAGAGCCGAGAATCGGTGCG
ACGCATTATCAGCTATGCCCACCGTAAAAATTCTAAGTTAGTACGCAGCATCGCGGTGTTTGATGCCAAT
CATGAGCTGTTTGTCACCTCGAACTTCCACCCCAATTTCGAAAAGCTGATGTATCCCAAGGATAAGCCGA
TCCCGTTTCTGAGTAGTTCCGTGATTGACGAGAACACGCTGATATTACGAACGCCGATCATTTCTGAACG
CACCGTGCTCGACAATGGCGATGCTAATCCCGCCACACCGGTGATGGGTTATATTGCGATAGAACTGGAT
CTCTCCTCACTGCGTTTACAACAGTATCAGGAAATTTTTTCCGCTGGTTTAGTGCTAGTGATCGGGATTT
TGCTGTCAGGGGTATTTGCTTCGCGCTTGATGTACGATGTGACTCGCCCAATCACTCACATGAAAAATAT
GGTCGACCGCATTCGTCGCGGCCATTTGGATGTGCGGATTGAAGGTAAAATGCACGGCGAGTTGGATACG
CTGAAAAAAGGCATCAACGCGATGGCGGTATCGCTCTCCGAATACCATGTCGAAATGCAGCACAGTATCG
ACCAAGCGACGTCCGATCTCCGGGAAACCCTTGAACAGCTTGAGATTCAAAACGTTGAACTCGATATTGC
CAAAAAGCGCGCTCAAGAAGCGGCACGAGTAAAATCCGAATTTCTGGCTAACATGTCCCATGAGCTGCGC
ACCCCACTCAATGGTGTGATTGGTTTTACGCGGCAAATGCTGAAAACCCAGTTGACCAACAGCCAAGCAG
ATTATCTACAAACCATTGAAAAATCAGCCAATAACCTTCTCACCATCATCAATGACATTTTAGATTTTTC
CAAACTCGAAGCCGGTAAGCTGGCTTTGGAGAATATTCCGTTTGAATTCCAAGAAGTATTGGAAGAGGTG
GTTAATCTGCAAGCCACCAGCGCGCATGAAAAAGGGTTAGAAATCACCCTCAAGATTGACCCGAAAATTC
CGCGCGGCGTGGTGGGCGATCCGCTACGGATTCAGCAAGTCTTGACCAACTTGGTCGGTAACTCCATTAA
GTTTACCGAGCGTGGCAATATAGACGTGAGCGTGGAAATGCGTGCGCTACGCGATGATGTGATCGACCTG
CAATTTATGGTGCGCGACACCGGAATTGGCATTTCTGAGCGCCAGCAAGCTCAGTTATTCCAAGCCTTTA
GCCAAGCGGATGCCAGTATTTCACGCCGTTATGGCGGTACAGGACTTGGGTTGGTGATTACCCAAAAACT
GGTCAGCCATATGGGCGGAGAAATCAGCCTCACCAGCCGTTTGCACCAAGGTTCAACCTTCTGGTTCACG
CTGCGCCTGCATACCACAGAGCTGCCTCTCAATGACGGTTATAACGCGGACTCGCTCAATCATCGCCACT
TGCTGCTGATTGAACCCAATATGCAAGCCGCTGCGATTGTGCAGCAAACGCTGGTCCAAAGTGGTTTAGA
AGTGACGTACCGCTCTGCGATTCCGGAAGAGCAACACGTTTACGACTATGTACTGCTCAACTTAGCGCCT
AGTAAAGAGACCAATCCGACCTTGGTGGAGCTTTGGGTGCAACGCGCGTTAGCCATGACCCACAATGTGA
TTGTCGGTGTGCCGAGCACAGAACTGGCGCTCGCCGACCAATTGATGCAGCGCTACCCAGTAAAATGCAT
CAGTAAGCCTTTATCTCGCAAAAAACTGCTACAAACCTTGGCAGCGCAACAGCCGCAACTCGCCAATACC
AGTTTGCCCAAACCTCAAGCCGATAAGCTTCCGCTGTGCGTCATGGCGGTCGATGATAATCCAGCCAACC
TCAAACTCATCACTGCGCTATTGCAAGAGCGGGTTGAGTACGTGGTCTCTTGCACCAGCGGTCAGGAGGC
GATTGAGCAAGCTCAGAGCCGTCAGTTCGATATCATCTTGATGGACATTCAAATGCCGCACATGGATGGA
GTGACCGCTTGTAAAGCGATCAAGCAGCTCAAAGGGTATCGTGATACGCCAGTCATTGCGGTCACCGCAC
ATGCCATGGCAGGCGAGCGTGACCGTCTACTGAAAGCGGGGATGGATGATTACCTGACCAAACCGATTGA
AGAGCATATTCTGCAACAAGTGTTGGTACATTGGAGCCCGCACACGCGCAGTAAACAGGTCGCGAAAGTG
ACCCCACCCGATGGTGCTGCGGTCATATCTAACGCCTTACCCTCATCACCGCCAGCAGAAGAGGCCATTA
TTGATTGGCCTGTCGCGCTGCGCCAATCCGCCAATAAAGAGGATCTCGCCAAAGAGATGCTCGGGATGTT
GGTCGATTATTTGCGGGAAGTCGAAACTGTGGTCAATACTGCGCTTGAGGATGAAGAATACCCCGCTAGC
GATCTGCTGCATCATATCCATAAGTTGCATGGCAGTTGTTCGTACAGCGGCGTACCGCGCCTGCGAAAAA
TCTGCGCCAGTTTGGAGCAAGCGCTGCGCAATGGGGCGAGCATCGATGAGTTAGAGCCTGAGTTATTTGA
GTTGCAAGATGAGATGGCGAAAGTGCTCGAAGCCTCTCGCGACTATCTGAACTG
Protein Sequence 
>gi|15642449|ref|NP_232082.1| hybrid sensory histidine kinase BarA [Vibrio cholerae O1 biovar El Tor str. N16961]
MTQRYGLRARVMTLTLAPTLIIGLLLSALFSFNRYHDLETQVINSGASIIEPLAIASEDALRMQSRESVR
RIISYAHRKNSKLVRSIAVFDANHELFVTSNFHPNFEKLMYPKDKPIPFLSSSVIDENTLILRTPIISER
TVLDNGDANPATPVMGYIAIELDLSSLRLQQYQEIFSAGLVLVIGILLSGVFASRLMYDVTRPITHMKNM
VDRIRRGHLDVRIEGKMHGELDTLKKGINAMAVSLSEYHVEMQHSIDQATSDLRETLEQLEIQNVELDIA
KKRAQEAARVKSEFLANMSHELRTPLNGVIGFTRQMLKTQLTNSQADYLQTIEKSANNLLTIINDILDFS
KLEAGKLALENIPFEFQEVLEEVVNLQATSAHEKGLEITLKIDPKIPRGVVGDPLRIQQVLTNLVGNSIK
FTERGNIDVSVEMRALRDDVIDLQFMVRDTGIGISERQQAQLFQAFSQADASISRRYGGTGLGLVITQKL
VSHMGGEISLTSRLHQGSTFWFTLRLHTTELPLNDGYNADSLNHRHLLLIEPNMQAAAIVQQTLVQSGLE
VTYRSAIPEEQHVYDYVLLNLAPSKETNPTLVELWVQRALAMTHNVIVGVPSTELALADQLMQRYPVKCI
SKPLSRKKLLQTLAAQQPQLANTSLPKPQADKLPLCVMAVDDNPANLKLITALLQERVEYVVSCTSGQEA
IEQAQSRQFDIILMDIQMPHMDGVTACKAIKQLKGYRDTPVIAVTAHAMAGERDRLLKAGMDDYLTKPIE
EHILQQVLVHWSPHTRSKQVAKVTPPDGAAVISNALPSSPPAEEAIIDWPVALRQSANKEDLAKEMLGML
VDYLREVETVVNTALEDEEYPASDLLHHIHKLHGSCSYSGVPRLRKICASLEQALRNGASIDELEPELFE
LQDEMAKVLEASRDYLN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: barA mutant is attenuated in mice (Merrell et al., 2002).
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].