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tolC

Victor ID 2397
Gene Name tolC
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2612978
NCBI Protein GI 15642433
Locus Tag VC2436
Protein Accession NP_232066.1
Other Database IDs UniProtKB-ID: TOLC_VIBCH
UniRef100: UniRef100_Q9K2Y1
UniRef90: UniRef90_Q9K2Y1
UniRef50: UniRef50_Q9K2Y1
UniParc: UPI0000137110
EMBL: AF282892
EMBL: AE003852
EMBL-CDS: AAF91468.1
EMBL-CDS: AAF95579.1
RefSeq_NT: NC_002505.1
TCDB: 2.A.6.2.30
GenomeReviews: AE003852_GR
KEGG: vch:VC2436
TIGR: VC_2436
HOGENOM: HBG647495
OMA: YINSIIA
ProtClustDB: PRK09465
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 2610549
Gene Ending Position 2611865
Gene Strand (Orientation) +
Protein Name outer membrane channel protein
DNA Sequence 
>gi|15640032:2610549-2611865 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
GATGAAAAAACTGCTTCCATTATTTGTTAGTGCTGCGCTAGGCACACTAAGCTCTGCCGTTTGGGCAGAA
AACCTGGCAGAGATTTATAACCAAGCAAAAGAAAATGATCCCCAATTACTCAGCGTAGCGGCTCAACGTG
ATGCTGCGTTTGAAGCGGTGACTTCTAGCCGTAGTGCCCTTTTACCGCAAATTAATCTGACGGCGGGTTA
CAACATCAACCGCAGTGATCAAGCCCCACGCGAAAGTGATCTTCTCTCTGCAGGCATCAACTTTTCACAA
GAACTGTACCAACGTTCTAGCTGGGTAAGCTTAGATACGGCTGAGAAAAAAGCCCGCCAAGCAGACTCTC
AATACGCTGCCACGCAACAAGGCTTAATCTTACGTGTGGCGAAGGCTTATTTTGAAGTGCTCCGCGCTCA
AGATAACCTTGAATTCGTGCGCGCAGAAAAAGCCGCCGTGGGTCGCCAATTAGAGCAAACCAAACAACGC
TTTGAAGTCGGTTTGTCAGCGATTACCGACGTACATGATGCACAGGCACAATTCGATGGTGTATTAGCCG
ATGAAGTGTTGGCGGAAAACAGCCTCACCAATAGCTATGAAGCTCTGCGTGAAATTACGGGTCAGGAATA
CTCTAAGCTTGCGGTACTCGATACCAAACGATTTGCGGCGAGTCGTACGACCGAATCAAGCGAAGCGTTG
ATCGAAAAAGCGCAACAGCAAAATTTATCGCTGCTTGCTGCTCGTATCAGTCAAGATGTCGCACGTGACA
ACATTTCGCTTGCCAGCTCTGGCCATCTGCCATCACTGACCTTAGATGGTGGTTACAACTATGGCAACAA
TAGCAACGACAATGCGAAAAACACTTCAGGCGAAGAGTACAACGATTTCAAAATCGGCGTGAACCTCAAA
GTACCGCTGTACACAGGTGGCAACACCACGTCACTGACCAAGCAGGCTGAATTTGCGTATGTAGCCGCCA
GCCAAGATCTGGAAGCCGCTTACCGCTCAGTGGTTAAAGATGTGCGTGCATACAACAACAACATCAACGC
TTCAATTGGTGCACTGCGTGCTTATGAGCAGGCAGTGATTTCTGCGAAGTCAGCACTGGAAGCGACCGAA
GCAGGTTTTGATGTCGGTACGCGTACCATTGTCGATGTACTCGATGCCACACGTCGCCTGTATGATGCGA
ACAAAAATCTCTCGAATGCTCGCTATGACTACATTCTCAGTGTGCTGCAATTGCGCCAAGCGATTGGTAC
TCTGAGTGAGCAAGACGTGATGGATGTCAACGCAGGCCTAAAAGTCGCGAAGAAGTA
Protein Sequence 
>gi|15642433|ref|NP_232066.1| outer membrane channel protein [Vibrio cholerae O1 biovar El Tor str. N16961] MKKLLPLFVSAALGTLSSAVWAENLAEIYNQAKENDPQLLSVAAQRDAAFEAVTSSRSALLPQINLTAGYNINRSDQAPRESDLLSAGINFSQELYQRSSWVSLDTAEKKARQADSQYAATQQGLILRVAKAYFEVLRAQDNLEFVRAEKAAVGRQLEQTKQRFEVGLSAITDVHDAQAQFDGVLADEVLAENSLTNSYEALREITGQEYSKLAVLDTKRFAASRTTESSEALIEKAQQQNLSLLAARISQDVARDNISLASSGHLPSLTLDGGYNYGNNSNDNAKNTSGEEYNDFKIGVNLKVPLYTGGNTTSLTKQAEFAYVAASQDLEAAYRSVVKDVRAYNNNINASIGALRAYEQAVISAKSALEATEAGFDVGTRTIVDVLDATRRLYDANKNLSNARYDYILSVLQLRQAIGTLSEQDVMDVNAGLKVAKK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: tolC mutant is deficient in intestinal colonization of mice (Bina and Mekalanos, 2001).
COG COG1538MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport
References
Bina and Mekalanos, 2001: Bina JE, Mekalanos JJ. Vibrio cholerae tolC is required for bile resistance and colonization. Infection and immunity. 2001; 69(7); 4681-4685. [PubMed: 11402016].