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VC0028

Victor ID 2393
Gene Name VC0028
Sequence Strain (Species/Organism) Vibrio cholerae O1 biovar El Tor str. N16961
NCBI Gene ID 2612960
NCBI Protein GI 15640060
Locus Tag VC0028
Genbank Accession AE003852
Protein Accession NP_229687
Other Database IDs UniProtKB-ID: ILVD_VIBCH
UniRef100: UniRef100_A5F497
UniRef90: UniRef90_A5F497
UniRef50: UniRef50_Q5F8G6
UniParc: UPI000012D594
EMBL: AE003852
EMBL-CDS: AAF93206.1
RefSeq_NT: NC_002505.1
GenomeReviews: AE003852_GR
KEGG: vch:VC0028
TIGR: VC_0028
HOGENOM: HBG671001
OMA: KVPCLSK
ProtClustDB: PRK12448
Taxonomy ID 243277
Chromosome No I
Gene Starting Position 24791
Gene Ending Position 26632
Gene Strand (Orientation) -
Protein Name dihydroxy-acid dehydratase
Protein pI 6.08
Protein Weight 61566.14
Protein Length 613
Protein Note catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
DNA Sequence 
>gi|15640032:24791-26632 Vibrio cholerae O1 biovar El Tor str. N16961 chromosome I, complete genome
CTTAGCCCTCAAGTTTGGACTTATCGCGCACTGCACCTTTGTCGGCGCTGGTTGCCATGCTGGCATAAGC
TTTCAGCGCCAAAGAAACGGTACGCTGGCGATCCACTGGTTTCCAGCCGAGTTTATCTTGTTCAGCGCGG
CGAGCTGCTAGCTCAGATTCGCTGACTTCGAGCGTGATCGAACGGTTGGGAATATCAATCGCGATGCTAT
CGCCACTGCGTACCAAGCCGATCGTACCGCCATTCGCCGCTTCCGGAGAGGCGTGACCAATCGACAAGCC
GGACGTACCACCGGAGAAGCGGCCATCGGTCAGTAGCGCGCACTGTTTACCCAGTCCCATCGATTTGAGG
TAGGTGGTTGGGTAGAGCATCTCTTGCATGCCCGGACCGCCTTTTGGCCCTTCATAACGAATAACCACGA
CGTCACCGGCTTTGACTTGGCCGCCAAGAATGCCGTTGACCGCGTCTTCCTGACTTTCATACACCACAGC
AGGACCACGGAATTTGAGGATACTTTCATCCACGCCAGCAGTTTTTACGATGCAGCCGTCAATCGCCAAG
TTGCCTTTGAGTACGGCAAGGCCACCATCTTGACTGAATGCGTGCGCTTTATCGCGAATACACCCCTCTT
GGCGATCGTCATCGAGCGTATCCCAACGGCAATCTTGTGAGAAAGCTTGAGTGGTGCGAATGCCAGCAGG
GCCTGCGCGGAACATAGTATGTACCGCTGGATCTTGGGTTTGTTTCACGTCGTATTGCGCCAGCTGCTCT
TGCAGCGAGATGCCTAGTACGGTGCGGGTTTGATCCTTGAGTAGACCTGCACGTTGTAGCTCACCCAAAA
TGCCCATTACACCGCCCGCGCGGTGTACATCTTCCATATGGTATTTCTGAGTGGAAGGCGCGACTTTACA
TAAGTGTGGCACTTGGCGAGACATGCGATCGATATCGGTCATATCAAATTCCACTTCGCCTTCCTGCGCA
GCGGCCAACAGGTGTAACACCGTGTTGGTGGAGCCGCCCATCGCAATATCCAGCGCAATGGCGTTTTCAA
ACGCTGCTTTGTTGGCAATGTTGCGTGGCAAAACTGAGGCATCATCTTGCTCGTAGTAACGTTTAGTCAG
CTCAACAATCCGTTGCCCAGCAGTCAAAAACAGCTGTTTGCGATCGGCATGCGTGGCGAGCAGTGAGCCG
TTACCCGGCTGAGAGAGACCCAGCGCTTCGGTCAAGCAGTTCATTGAGTTGGCGGTAAACATCCCCGAGC
AAGAGCCACAAGTAGGACAGGCCGAGCGTTCAATCTGCTCACTTTGGGCATCCGATACTTTGGGGTCAGC
GCCTTGCATCATGGCATCGACCAAGTCGAGCTTGATGATTTGGTCAGAAAGCTTGGTTTTTCCCGCTTCC
ATCGGGCCGCCAGAGACGAAAATCGCCGGAATATTAAGGCGCATCGCCGCCATCAGCATTCCTGGAGTGA
TTTTGTCACAGTTGGAGATACACACCATGGCATCGGCGCAGTGCGCATTGACCATGTATTCGACGGAATC
GGCGATCAGTTCACGCGATGGCAGCGAGTAGAGCATGCCGCCGTGGCCCATGGCGATGCCGTCATCGACC
GCAATGGTGTTGAATTCTTTGGCAATGCCGCCCGCGGCTTCAATTTCGCGTGCGACCAGTTGGCCGAGAT
CTTTTAAATGCACATGGCCGGGAACAAATTGGGTGAAGGAGTTGACCACCGCAATGATCGGTTTACCAAA
ATCTTCCTCTTTGACGCCGGTGGCGCGCCATAATGCGCGCGCACCCGCCATGTTACGTCCGTGTGTGGTG
GTGGCGGAACGGTACTTAGGCA
Protein Sequence 
>gi|15640060|ref|NP_229687.1| dihydroxy-acid dehydratase [Vibrio cholerae O1 biovar El Tor str. N16961]
MPKYRSATTTHGRNMAGARALWRATGVKEEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGI
AKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPA
IFVSGGPMEAGKTKLSDQIIKLDLVDAMMQGADPKVSDAQSEQIERSACPTCGSCSGMFTANSMNCLTEA
LGLSQPGNGSLLATHADRKQLFLTAGQRIVELTKRYYEQDDASVLPRNIANKAAFENAIALDIAMGGSTN
TVLHLLAAAQEGEVEFDMTDIDRMSRQVPHLCKVAPSTQKYHMEDVHRAGGVMGILGELQRAGLLKDQTR
TVLGISLQEQLAQYDVKQTQDPAVHTMFRAGPAGIRTTQAFSQDCRWDTLDDDRQEGCIRDKAHAFSQDG
GLAVLKGNLAIDGCIVKTAGVDESILKFRGPAVVYESQEDAVNGILGGQVKAGDVVVIRYEGPKGGPGMQ
EMLYPTTYLKSMGLGKQCALLTDGRFSGGTSGLSIGHASPEAANGGTIGLVRSGDSIAIDIPNRSITLEV
SESELAARRAEQDKLGWKPVDRQRTVSLALKAYASMATSADKGAVRDKSKLEG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: VC0028 mutant was attenuated in mice (Merrell et al., 2002).
COG COG0129EG, under E: Amino acid transport and metabolism; G: Carbohydrate transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].