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zot from Vibrio cholerae O395

Victor ID 2380
Gene Name zot from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5134487
NCBI Protein GI 147672022
Locus Tag VC0395_0511
Protein Accession YP_001215350.1
Taxonomy ID 345073
Chromosome No 1
Gene Starting Position 565052
Gene Ending Position 566251
Gene Strand (Orientation) +
Protein Name zona occludens toxin
DNA Sequence 
>gi|147671401:565052-566251 Vibrio cholerae O395 chromosome 1, complete sequence
TATGAGTATCTTTATTCATCACGGCGCGCCAGGCTCTTATAAAACGTCCGGGGCATTATGGCTTCGTCTG
CTGCCGGCGATTAAGTCAGGCCGTCACATCATCACGAATGTGCGAGGCTTAAACCTTGAACGCATAGCTA
AGTACTTAAAAATGGACGTCTCAGACATCAGTATCGAGTTTATTGATACAGACCATCCAGACGGTCGCTT
AACGATGGCGCGTTTTTGGCACTGGGCGAGAAAGGACGCGTTTCTCTTTATTGATGAATGTGGTCGCATC
TGGCCGCCGAGACTGACGGCCACCAATTTAAAGGCGCTCGACACGCCGCCGGATTTGGTCGCAGAGGATA
GGCCTGAGAGCTTTGAGGTGGCTTTTGACATGCATCGTCACCACGGCTGGGATATCTGCCTAACCACGCC
TAACATTGCCAAAGTGCACAACATGATAAGAGAGGCGGCGGAGATAGGGTATCGCCACTTTAACCGCGCC
ACGGTGGGGCTAGGGGCAAAGTTTACCCTGACCACCCACGATGCAGCCAACTCTGGACAGATGGATTCGC
ACGCGCTGACACGCCAAGTCAAAAAAATTCCAAGTCCGATTTTTAAGATGTACGCAAGCACCACCACAGG
CAAAGCACGCGACACGATGGCCGGAACGGCGCTGTGGAAAGACAGAAAGATCCTTTTCTTGTTCGGCATG
GTTTTTTTGATGTTCTCTTATTCGTTTTACGGCTTACACGACAATCCAATTTTTACAGGGGGAAATGATG
CAACTATCGAGTCAGAGCAATCCGAGCCTCAGTCAAAGGCTACTGCTGGGAATGCTGTCGGGAGCAAGGC
GGCTGCTCCTGCGTCTTTTGGTTTTTGTATTGGTCGGCTTTGTGTCCAAGATGGTTTTGTCACTGTTGGT
GATGAGCGTTATCGCCTCGTAGACAATTTGGACATTCCTTATCGTGGTCTATGGGCGACAGGTCATCACA
TTTACAAGGATACGCTTACAGTGTTTTTTGAAACCGAGAGTGGCAGCGTCCCAACAGAGCTGTTTGCATC
GAGCTACCGCTACAAGGTGCTACCGTTACCGGATTTCAATCACTTTGTGGTGTTCGATACCTTTGCAGCG
CAAGCGCTGTGGGTAGAAGTGAAACGGGGTTTACCGATAAAAACAGAAAATGATAAAAAAGGACTAAATA
GTATATTTTG
Protein Sequence 
>gi|147672022|ref|YP_001215350.1| zona occludens toxin [Vibrio cholerae O395] MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWARKDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFNRATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSYSFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGLWATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: The zot toxin increases the permeability of the small intestinal mucosa by affecting the structure of the intercellular tight junction, or zonula occludens (Fasano et al., 1991).
COG COG4128R, under R: General function prediction only
References
Fasano et al., 1991: Fasano A, Baudry B, Pumplin DW, Wasserman SS, Tall BD, Ketley JM, Kaper JB. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proceedings of the National Academy of Sciences of the United States of America. 1991; 88(12); 5242-5246. [PubMed: 2052603].