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acfB from Vibrio cholerae O395

Victor ID 2367
Gene Name acfB from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5137124
NCBI Protein GI 147673778
Locus Tag VC0395_A0365
Protein Accession YP_001216321.1
Taxonomy ID 345073
Chromosome No 2
Gene Starting Position 392233
Gene Ending Position 394113
Gene Strand (Orientation) +
Protein Name accessory colonization factor AcfB
DNA Sequence 
>gi|147673035:392233-394113 Vibrio cholerae O395 chromosome 2, complete sequence
AATGAAGTTTTCTATCAAGTTACTAATGATTTTTACATCAATTATAATTACTATTTCATCTATCCTTACT
TACTTTCAGATGCATGGAACCAATGAATATCTTGATCGTACGATAAAAGATACTATTTCTGAAACGCTAG
ACTCTTTGGAAGATAAAATAAATCTTTCTATTGAGTCCAAGGTCGATGTGTCAAAATCTGTTATCGACAT
TTATGAAAATTTACTGGAGGGGGAATCCCCTCTCAGTAAATTTAAGGATGTTGATGTCAATCATCTTTCA
AATGTTTTTCAATTGTTCGGATATGCTGATGAAAGAACAGGAGAGATCATTACTAATGACCCAAACTTTA
AAGTGCCTACAGGATTCGATCCAAGGACTCGATCGTGGTATTTAAATGCAAAAAAATTGAATACCTTTAG
TTTGTCTGAGCCGTATGTCGATCTCATTACAGAGAAGTTAATGGTGACAACAAGTGCACCAATATATAAT
AAAAACGATTTAACAGGAGTTATATTTTTTGATATACCACTAGATGACGTTCAGGAATTAATTAAAAGCT
ACAATCCATTTGATGCCGGCACGATTTTTATCGTTGATAACAGTGGGAAAATAATTTTCGGTAATAAAAA
TGATATATCGGGTAAAAATTTATTTGGAGACTTTGATAGCTTCCCTCTATCGGTAAGTGAGTCAAAAACG
AAAGATAAAAATGGGGTAAATTACGATGTATTCATCAAAATGTCAGACTTTGGCGATTGGAATCTTGTTT
CTATTATCGACCATGATAAAGCACGCTCTGATATTATCACGTTGAGAAACAATAGTATATTTACTGCCGT
CATTTTAGCAAGTGTTTTCTTTGCTATCTTGTTGTTTACTATGCGGTTAATGCTGAAGCCATTGCATCAA
TTAACCGATGCAATGGTAAATATTTCATCGGGCAGTGCTGATCTTACGGTTCGTATCCCGAATAGTACGG
ATCAAGAGTTTTCAAAAATAATAAATTCCTTTAACATTTTTGTTGGTAATCTGCAATCTATTGTGTCGGA
GGTTAAAATGAACTCAGAAAAAATAAATTGCATAACTACTGAAACACAAGAGCTAGTCGAAGTTTGCAAT
AATAGCGTAGCTGATCAGTATCGTGAACTTGATATGCTAGCTAGCTCAATGAATGAGATGGTGGCAACAT
CTAATCAGATTGCACAAATTACATCCGAAGCATCAGAGATCACATCTAAGATTAACGGTCAAGTGAATGA
AGGAGTCGGTGCTGTTTCTTCTGTTACCGAAAGTGTAGGTAATTTAGTTGAGAAGTTGGATAAGACGAAA
TCTGTTATCCAAGATCTTAATCGCCAAACTCAAAATATAGATGTTATTTTGAAGGCTATTAATGATATTG
CTGACCAAACAAACCTTCTTGCTCTTAATGCTGCAATTGAGGCTGCACGAGCTGGGGAAAATGGACGAGG
TTTTGCTGTGGTTGCTGATGAGGTACGCAGCCTAGCAATAAAGACACAAGAGTCTACTAAAAATATAGGA
AGTATTATCCATATATTACAAGAAAACTCTTTGCTATCCGTTCATGTTATGGATGAAAGTTTTAATATTG
CCTCTGAAACTATGACTATATCAGCTGATTCAAAACAATGTTTAGACAATATTAGTCAATCAGTAATACA
AATTGTTGATATCACAAATCAAGTAGCTACAGCTGCTTACGAACAAAGTCACGTATCAGAGGAAATAAAC
AGCAACTCTATTTCTATAAAAGATAAAGCAGATACCTTATCAAGTTTGGGTAATAAGATTTCTCAACAGG
CTTATTCTCAAAAAGCACTGATTGGTCATCAAGATGATTTAATCAGTAAGTTTATCATTTA
Protein Sequence 
>gi|147673778|ref|YP_001216321.1| accessory colonization factor AcfB [Vibrio cholerae O395] MKFSIKLLMIFTSIIITISSILTYFQMHGTNEYLDRTIKDTISETLDSLEDKINLSIESKVDVSKSVIDIYENLLEGESPLSKFKDVDVNHLSNVFQLFGYADERTGEIITNDPNFKVPTGFDPRTRSWYLNAKKLNTFSLSEPYVDLITEKLMVTTSAPIYNKNDLTGVIFFDIPLDDVQELIKSYNPFDAGTIFIVDNSGKIIFGNKNDISGKNLFGDFDSFPLSVSESKTKDKNGVNYDVFIKMSDFGDWNLVSIIDHDKARSDIITLRNNSIFTAVILASVFFAILLFTMRLMLKPLHQLTDAMVNISSGSADLTVRIPNSTDQEFSKIINSFNIFVGNLQSIVSEVKMNSEKINCITTETQELVEVCNNSVADQYRELDMLASSMNEMVATSNQIAQITSEASEITSKINGQVNEGVGAVSSVTESVGNLVEKLDKTKSVIQDLNRQTQNIDVILKAINDIADQTNLLALNAAIEAARAGENGRGFAVVADEVRSLAIKTQESTKNIGSIIHILQENSLLSVHVMDESFNIASETMTISADSKQCLDNISQSVIQIVDITNQVATAAYEQSHVSEEINSNSISIKDKADTLSSLGNKISQQAYSQKALIGHQDDLISKFII
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: acfB mutant had a defect in colonization of mice, and had a ten-fold increase in the 50% lethal dose in mice (Peterson and Mekalanos, 1988).
COG COG0840NT, under N: Cell motility; T: Signal transduction mechanisms
References
Peterson and Mekalanos, 1988: Peterson KM, Mekalanos JJ. Characterization of the Vibrio cholerae ToxR regulon: identification of novel genes involved in intestinal colonization. Infection and immunity. 1988; 56(11); 2822-2829. [PubMed: 2902009].