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purL from Vibrio cholerae O395

Victor ID 2354
Gene Name purL from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5136680
NCBI Protein GI 147673351
Locus Tag VC0395_A0395
Protein Accession YP_001216350.1
Taxonomy ID 345073
Chromosome No 2
Gene Starting Position 422588
Gene Ending Position 426481
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamidine synthase
DNA Sequence 
>gi|147673035:422588-426481 Vibrio cholerae O395 chromosome 2, complete sequence
CATGAGAATTTTGCGTGGCTCCCCAGCTCTTTCAGAGTTTCGTGTTAACAAGCTCCTGACCGCGTGTCGT
GAACAGCAACTGCCTGTAACCGGTATTTACGCCGAGTTTATGCACTTTGCCGATCTCAAGGCAGAGCTCA
ATCCGCAAGAGTTGGAAAAGCTCGAAAAACTGCTCACTTATGGTCCAACCATTCAAGAGCATGAACCGCA
AGGTTTACTGCTGTTGGTGACGCCGCGCCCCGGAACCATCTCACCTTGGTCCTCAAAAGCCACCGATATT
GCACACAACTGTGGCCTGCATGGCATCAAGCGCCTTGAGCGCGGTACGGCTTATTATGTTGAAGCAGAAA
CGGCGCTGACCGCAGCACAAATCGCAACACTTGAGGCGCTGCTGCATGATCGAATGATGGAAGTCGTGTT
CGCAGAACTCACCGATGCCCAGCAACTGTTCAGCGTAGCAGAGCCTGCGCCTATGAGTCAGGTCGATGTA
TTAGCGGGCGGTCGTCGTGCGCTTGAAGAGGCAAACGTTTCCCTTGGTCTGGCATTGGCTGAAGATGAAA
TTGATTATCTGGTTGAGAGCTTCACTAAACTGGGTCGTAATCCTAACGACATTGAACTGATGATGTTTGC
ACAGGCGAACTCAGAGCACTGCCGCCACAAGATTTTCAACGCCGATTGGACCATTGATGGAGTTAAGCAA
GACAAGTCACTGTTCAAAATGATCAAAAACACCTTTGAACAGACGCCGGATTATGTGCTTTCGGCTTATA
AAGATAATGCCGCAGTAATGACGGGCTCGACCGTTGGCCGTTTCTTCCCCGACCCCGAGAGCCGTCAGTA
CACTTATCACCATGAAGATGCCCACATTCTGATGAAAGTGGAAACGCATAACCACCCAACGGCGATTTCG
CCTTGGCCGGGGGCTTCGACTGGTTCTGGCGGTGAAATTCGTGATGAGGGCGCAACCGGTATTGGCGGCA
AGCCTAAAGCGGGATTGGTGGGCTTTACCACCTCGAACTTGCGTATTCCCGGTTTTGAACAGCCATGGGA
AAGCGATTTTGGTAAGCCAAGCCGCATTGTGAATGCGCTGGATATCATGCTGGAAGGGCCACTCGGCGGC
GCGGCGTTCAACAACGAATTTGGTCGCCCGAACCTACTTGGGTATTTCCGCACTTATGAAGAAAAAGTGA
CGTCACATGCTGGTGAAGAGGTGCGTGGTTATCACAAGCCGATCATGATTGCCGGCGGTATGGGTAACAT
TCGCGCCGAGCATATTCAGAAGAAAGAGATCCCAGTGGGGGCAAAACTGATCGTACTCGGAGGCCCTGCG
ATGAACATCGGTCTCGGTGGTGGCGCAGCCTCTTCGATGGCTTCTGGCCAGTCTGCTGAAGATCTGGATT
TTGCTTCTGTGCAGCGTGAAAACCCAGAGATGGAGCGCCGCTGTCAGGAAGTGATTGACCGTTGTTGGCA
GCTCGGTGACAAAAACCCGATCGCCTTTATCCACGATGTGGGCGCGGGTGGTATCTCTAACGCTCTGCCT
GAGCTGGTGAATGACGGCGATCGCGGTGGTAAATTCCAGTTGCGCAACGTGCCGAATGATGAGCCGGGCA
TGAGCCCATTGGAAATCTGGTGTAATGAATCACAAGAGCGTTATGTGCTGGCGGTTGCTGCGGAAGATAT
GCCGCTGTTTGATGCGATTTGCCAGCGTGAACGCGCCCCTTATGCCGTGGTAGGTGAAGCGACCGAAGAG
CGCCATTTGACGCTGGAAGACAGCCACTTTGCTAACACGCCGATTGATATGCCAATGGATATTCTGTTGG
GTAAGCCGCCGAAAATGCATCGTGAAGCGAGCACGCTGAAAGTTTCAAGCCCAGCGCTAGAGCGTTCAGG
CATTGAGCTTAATGAAGCGGTGGATCGCGTACTGCGTTTACCGGCAGTCGCAGAAAAAACGTTCCTGATC
ACCATTGGTGACCGCTCAGTGACTGGCTTAGTCGCGCGGGATCAAATGGTCGGCCCATGGCAAGTTCCCG
TCGCAAACTGCGCAGTAACGGCCGCGAGTTTTGATTCTTACCACGGCGAAGCGATGTCTATGGGTGAGCG
TACCCCTGTTGCGCTGTTGGATTTCGGTGCCTCTGCACGTTTAGCGGTCGGTGAAGCTATTACCAACATA
GCCGCAACCGATATTGGCGAGCTGAAACGCATCAAACTTTCGGCGAACTGGATGTCTCCAGCGGGCCATC
CGGGTGAAGATGCCGGTCTGTATGAAGCGGTGAAAGCGGTCGGTGAAGAGCTTTGTCCTGCACTGGGTAT
CACTATCCCAGTCGGTAAAGACTCGATGTCGATGAAAACCAAGTGGCAGGAAAATGGCGAGCAGAAAGAA
GTGACTTCGCCGCTGTCACTCATCATCACCGCCTTTGCACGTGTGGAAGACATTCGCAAGACCGTGACCC
CACAACTGCGTACTGACCTTGGTGAGACAAGCTTAATCTTGATTGACTTGGGGAATGGTCAAAATCGTCT
TGGCGCAACCGCATTGGCGCAAGTGTACAAACAGTTGGGTGATAAGCCGGCTGATGTGGATAACGCGGCG
CAGCTCAAAGGCTTTTTTGATGCAGTACAAACGCTGGTGCGTAACGACAAGCTGGTGGCTTACCACGACA
AAGGTGACGGCGGTTTATTGGTGACGTTGGCAGAAATGGCTTTCGCGGGTCACTGTGGTATTAAAGCCAA
TATTGAAACCTTGGGTGATGATGCACTGGCGGCACTGTTCAATGAAGAGCTTGGCGCCGTGGTTCAAGTG
AAAAATGATGAGCTGAATGCTGTTCTGGCAACACTTGCCGCCCATGGTTTAGAAGCGTGTGCTCACGTGA
TTGGTGAAGTAGAAGCATCCGATCGTCTGCTGATCACTTGTGGTGAGGAAGTCTTGATTGAGCGCTCTCG
TACTGAGCTTCGCACCATCTGGGCGGAAATGACCCATAAGATGCAAGCGCTGCGTGATAACTCGGCGTGT
GCTGATCAAGAGTTTGCGGCCAAACAAGATAACCGTGACCCGGGCTTGAATGCGAAGTTAACTTACGATG
TGCAAGCCGACGTTGCTGCGCCGTACATCGCCAAAGGTGTGCGTCCGAAAATGGCGATTTTGCGTGAGCA
AGGCGTCAACTCACACGTTGAGATGGCGGCAGCGTTTGACCGCGCTGGTTTTGATGCGGTTGATGTGCAT
ATGAGCGACATTCTGACTGGGCAAACCGTGCTCGATGCTTACCAAGGTCTGGTGGCTTGTGGTGGCTTCT
CTTACGGCGACGTATTGGGTGCGGGCGAAGGTTGGGCGAAATCGATTCTGTTTAACGCCCAAGCGCGTGA
GCAGTTTGAGCAGTTCTTCCAACGTAAAGATACTTTCTCACTTGGGGTGTGTAACGGCTGTCAAATGCTG
TCTAACCTGCGTGATTTGATCCCGGGTGCTGAGCTATGGCCACGTTTTGTGCGTAACGAATCGGATCGTT
TTGAAGCGCGCTTTAGCTTAGTCGAAGTGCAAAAATCGCCATCGCTGTTCTTTAGCGAGATGGCGGGCTC
AAGAATGCCGATTGCGGTTTCTCATGGTGAAGGTCGTGTGGAAGTGCGTGATGCTCAGCATCTGGCGGCA
ATTGAGCAATCTGGCACCGTAGCGATTCGTTTCGTGGATAACTTTGGTCAGCCAACCCAAGCTTACCCAA
GCAACCCGAACGGTTCACCGAATGCGATTACCGGTTTAACCACTCAAGATGGCCGTGTGACGATTATGAT
GCCGCACCCTGAGCGTGTATTCCGTACCGTCGCCAACTCGTGGCACCCTGATAACTGGGGTGAGAATGGC
GCTTGGATGCGTATGTTCCAGAATGCTCGTAAATATTTTGGCTA
Protein Sequence 
>gi|147673351|ref|YP_001216350.1| phosphoribosylformylglycinamidine synthase [Vibrio cholerae O395] MRILRGSPALSEFRVNKLLTACREQQLPVTGIYAEFMHFADLKAELNPQELEKLEKLLTYGPTIQEHEPQGLLLLVTPRPGTISPWSSKATDIAHNCGLHGIKRLERGTAYYVEAETALTAAQIATLEALLHDRMMEVVFAELTDAQQLFSVAEPAPMSQVDVLAGGRRALEEANVSLGLALAEDEIDYLVESFTKLGRNPNDIELMMFAQANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAAVMTGSTVGRFFPDPESRQYTYHHEDAHILMKVETHNHPTAISPWPGASTGSGGEIRDEGATGIGGKPKAGLVGFTTSNLRIPGFEQPWESDFGKPSRIVNALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSHAGEEVRGYHKPIMIAGGMGNIRAEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAASSMASGQSAEDLDFASVQRENPEMERRCQEVIDRCWQLGDKNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLEIWCNESQERYVLAVAAEDMPLFDAICQRERAPYAVVGEATEERHLTLEDSHFANTPIDMPMDILLGKPPKMHREASTLKVSSPALERSGIELNEAVDRVLRLPAVAEKTFLITIGDRSVTGLVARDQMVGPWQVPVANCAVTAASFDSYHGEAMSMGERTPVALLDFGASARLAVGEAITNIAATDIGELKRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGITIPVGKDSMSMKTKWQENGEQKEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRLGATALAQVYKQLGDKPADVDNAAQLKGFFDAVQTLVRNDKLVAYHDKGDGGLLVTLAEMAFAGHCGIKANIETLGDDALAALFNEELGAVVQVKNDELNAVLATLAAHGLEACAHVIGEVEASDRLLITCGEEVLIERSRTELRTIWAEMTHKMQALRDNSACADQEFAAKQDNRDPGLNAKLTYDVQADVAAPYIAKGVRPKMAILREQGVNSHVEMAAAFDRAGFDAVDVHMSDILTGQTVLDAYQGLVACGGFSYGDVLGAGEGWAKSILFNAQAREQFEQFFQRKDTFSLGVCNGCQMLSNLRDLIPGAELWPRFVRNESDRFEARFSLVEVQKSPSLFFSEMAGSRMPIAVSHGEGRVEVRDAQHLAAIEQSGTVAIRFVDNFGQPTQAYPSNPNGSPNAITGLTTQDGRVTIMMPHPERVFRTVANSWHPDNWGENGAWMRMFQNARKYFG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purL mutant is attenuated in mice (Merrell et al., 2002).
COG COG0046F, under F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].