Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

zot from Vibrio cholerae O395

Victor ID 2345
Gene Name zot from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5136175
NCBI Protein GI 147674144
Locus Tag VC0395_A1061
Protein Accession YP_001217007.1
Taxonomy ID 345073
Chromosome No 2
Gene Starting Position 1116042
Gene Ending Position 1117241
Gene Strand (Orientation) -
Protein Name zona occludens toxin
DNA Sequence 
>gi|147673035:1116042-1117241 Vibrio cholerae O395 chromosome 2, complete sequence
ATCAAAATATACTATTTAGTCCTTTTTTATCATTTTCTGTTTTTATCGGTAAACCCCGTTTCACTTCTAC
CCACAGCGCTTGCGCTGCAAAGGTATCGAACACCACAAAGTGATTGAAATCCGGTAACGGTAGCACCTTG
TAGCGGTAGCTCGATGCAAACAGCTCTGTTGGGACGCTGCCACTCTCGGTTTCAAAAAACACTGTAAGCG
TATCCTTGTAAATGTGATGACCTGTCGCCCATAGACCACGATAAGGAATGTCCAAATTGTCTACGAGGCG
ATAACGCTCATCACCAACAGTGACAAAACCATCTTGGACACAAAGCCGACCAATACAAAAACCAAAAGAC
GCAGGAGCAGCCGCCTTGCTCCCGACAGCATTCCCAGCAGTAGCCTTTGACTGAGGCTCGGATTGCTCTG
ACTCGATAGTTGCATCATTTCCCCCTGTAAAAATTGGATTGTCGTGTAAGCCGTAAAACGAATAAGAGAA
CATCAAAAAAACCATGCCGAACAAGAAAAGGATCTTTCTGTCTTTCCACAGCGCCGTTCCGGCCATCGTG
TCGCGTGCTTTGCCTGTGGTGGTGCTTGCGTACATCTTAAAAATCGGACTTGGAATTTTTTTGACTTGGC
GTGTCAGCGCGTGCGAATCCATCTGTCCAGAGTTGGCTGCATCGTGGGTGGTCAGGGTAAACTTTGCCCC
TAGCCCCACCGTGGCGCGGTTAAAGTGGCGATACCCTATCTCCGCCGCCTCTCTTATCATGTTGTGCACT
TTGGCAATGTTAGGCGTGGTTAGGCAGATATCCCAGCCGTGGTGACGATGCATGTCAAAAGCCACCTCAA
AGCTCTCAGGCCTATCCTCTGCGACCAAATCCGGCGGCGTGTCGAGCGCCTTTAAATTGGTGGCCGTCAG
TCTCGGCGGCCAGATGCGACCACATTCATCAATAAAGAGAAACGCGTCCTTTCTCGCCCAGTGCCAAAAA
CGCGCCATCGTTAAGCGACCGTCTGGATGGTCTGTATCAATAAACTCGATACTGATGTCTGAGACGTCCA
TTTTTAAGTACTTAGCTATGCGTTCAAGGTTTAAGCCTCGCACATTCGTGATGATGTGACGGCCTGACTT
AATCGCCGGCAGCAGACGAAGCCATAATGCCCCGGACGTTTTATAAGAGCCTGGCGCGCCGTGATGAATA
AAGATACTCA
Protein Sequence 
>gi|147674144|ref|YP_001217007.1| zona occludens toxin [Vibrio cholerae O395] MSIFIHHGAPGSYKTSGALWLRLLPAIKSGRHIITNVRGLNLERIAKYLKMDVSDISIEFIDTDHPDGRLTMARFWHWARKDAFLFIDECGRIWPPRLTATNLKALDTPPDLVAEDRPESFEVAFDMHRHHGWDICLTTPNIAKVHNMIREAAEIGYRHFNRATVGLGAKFTLTTHDAANSGQMDSHALTRQVKKIPSPIFKMYASTTTGKARDTMAGTALWKDRKILFLFGMVFLMFSYSFYGLHDNPIFTGGNDATIESEQSEPQSKATAGNAVGSKAAAPASFGFCIGRLCVQDGFVTVGDERYRLVDNLDIPYRGLWATGHHIYKDTLTVFFETESGSVPTELFASSYRYKVLPLPDFNHFVVFDTFAAQALWVEVKRGLPIKTENDKKGLNSIF
Molecule Role Virulence factor
Molecule Role Annotation TOXIN: The zot toxin increases the permeability of the small intestinal mucosa by affecting the structure of the intercellular tight junction, or zonula occludens (Fasano et al., 1991).
COG COG4128R, under R: General function prediction only
References
Fasano et al., 1991: Fasano A, Baudry B, Pumplin DW, Wasserman SS, Tall BD, Ketley JM, Kaper JB. Vibrio cholerae produces a second enterotoxin, which affects intestinal tight junctions. Proceedings of the National Academy of Sciences of the United States of America. 1991; 88(12); 5242-5246. [PubMed: 2052603].