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carB from Vibrio cholerae O395

Victor ID 2344
Gene Name carB from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5136051
NCBI Protein GI 147673654
Locus Tag VC0395_A1967
Protein Accession YP_001217891.1
Taxonomy ID 345073
Chromosome No 2
Gene Starting Position 2107280
Gene Ending Position 2110510
Gene Strand (Orientation) -
Protein Name carbamoyl phosphate synthase large subunit
DNA Sequence 
>gi|147673035:2107280-2110510 Vibrio cholerae O395 chromosome 2, complete sequence
ATTAAGCTTGGTTCGCTTTTACACGCGCATGCAGCTCTTGTACTGAAGTGACGGATGCTTTGGCATCCGC
CGTGTGTGACATACAAGTTGCGAAGGCGGCGTTCAGTGTGGTGGTGTAGTTCACTTTGTGAGCCAATGCA
CCACGGCGCAGTACTTTTGAGTCTTCAATTGCTTGGCGGCCAGAAGCCGTGTTCACAATGTAGGTGTACT
CGTGGTTTTTGATGCGATCCAGAATGTGTGGACGACCTTCATGCACTTTGTTAACCAGACGTGGGTTGAT
GCCCGCTTCGCCCAGAATCACTGCAGTACCGTGAGTCGCATCCAACTGGTAACCCAGTTTCACTAGCTTA
GAAGCCAGATCCACTACACGCTGTTTGTCACCTTCACGCACCGAAAGTAGCGCACGACCACCTTCAGGGT
AAACCGAGCCACAGCCCAACTCTGCTTTAGCATAGGCTTCAGCAAACGTGGCACCCACACCCATCACTTC
ACCGGTTGAGCGCATTTCAGGGCCAAGCAGTGGGTCAACCCCCGGGAACTTGTTGAACGGCAGAACCACT
TCTTTAACTGAGTAGTAAGGTGGAATGATCTCTTTGGTGAAGCCTTGTTGCTCCAGAGTTTGTCCAACCA
TCACGCGCGCCGCGATTTTCGCCAGCGGAGCACCGGTTGCTTTAGAAACAAACGGCACAGTACGCGCAGC
ACGTGGGTTTACTTCAATCAGGTAAACTTCGTTGTCTTTGACTGCAAACTGAATGTTCATCAGGCCACGA
ACACCGAGTTCAAATGCCAACTTCTCAACTTGCTCACGCATCTTGTCTTGGATTTCTTGGCTCAAGGTGT
AAGCCGGCAGAGAACAGGCTGAGTCACCTGAGTGAACACCCGCTTGTTCAATGTGCTCCATGATGCCGCC
AATCACCACGCGCTCACCGTCACAAATCGCATCCACGTCCACTTCGGTTGCATCATCAAGGAAGCGATCC
AGCAGAACTGGTGATTCATTCGACACGCTCACCGCTTCGTTGAAGTAACGACGCAGATCTTGCTCATCGT
ACACAATCTCCATCGCACGGCCACCCAGAACATAAGAGGGGCGAACTACGAGTGGGAAACCGATTTCACG
CGACTTCTCAATCGCTTGCTCGATAGCGGTTACGGTTGCGTTGTCTGGCTGTTTGAGGCCTAAACGCTGT
ACCGCTTGTTGGAAACGTTCACGGTCTTCAGCGCGGTCAATCGCATCTGGGCTGGTACCAATCACAGGTA
CGCCAGCCGCTTCCAGCGCTCGCGCCAGTTTCAGTGGTGTTTGACCGCCGTACTGCACGATCACGCCTTT
TGGCTTCTCAACACGCACGATAGCCAGCACATCCTCTAGAGTTACAGGCTCAAAGTAGAGGCGATCTGAG
GTGTCGTAATCGGTTGATACGGTTTCTGGGTTACAGTTAACCATGATGGTTTCGTAACCATCTTCACGCA
GTGCAAGCGCGGCGTGTACACAGCAGTAGTCAAACTCGATACCTTGACCGATACGGTTTGGACCACCGCC
CAGCACCATGATCTTGTCTTTGTCAGTCGGATTGGCTTCACACTCTTCATCATACGTGGAGTACATGTAA
GCGGTATCTGACTTAAATTCTGCCGCGCAGGTATCCACACGCTTGTAAACTGGGTGGATGTTGTATTGGT
CACGCAGACGACGGATTTCGTTTTCGCTAACGCCCAGCAGTTTTGACAGACGCGCATCAGAGAAGCCTTT
GCGCTTCATCTTACGCAATACGTCTTGGTTCAAGCCCGCAAAGCCACCGGCTTTCACTTCGGCTTCAAGC
TTCACCAGTTCTTCGATTTGCACTAGGAACCAGCGATCAATGTTGGTCAGGTTAAATACCCCATCCACTG
ACATACCGGCACGGAAGGCATCCGCGATGTACCAAATACGCTCTGCGCCTGCTTCTTTCAGCTCATAACG
AATTTTGGTCAGGGCATCTGGCGCGTCCAGATCCACTTTCTCATCCAGACCAGCCGCACCGACTTCCAAG
CCGCGCAGTGCTTTTTGCAGTGATTCTTGTTGGTTACGACCAATCGCCATCACTTCACCGACTGACTTCA
TTTGTGTGGTCAGGCGGTCATTGGCACCGGCGAATTTTTCGAAGTTGAAACGAGGAATCTTAGTGACCAC
GTAGTCGATGGTCGGTTCGAACGAAGCTGGCGTTGCGCCGCCTGTGATGTCGTTCATCAACTCATCGAGA
GTGAAACCCACCGCCAGTTTGGCCGCCACTTTCGCAATTGGGAAACCGGTGGCTTTGGAAGCCAACGCCG
AAGAGCGCGACACACGTGGGTTCATCTCGATGATCACCATGCGACCATCTTTCGGGTTGATACCAAACTG
AACGTTTGAACCGCCGGTTTCTACGCCGATTTCACGCAGTACCGCCAAAGAGGCGTTACGCATGATTTGG
TATTCTTTGTCCGTCAGGGTTTGCGCTGGAGCGACTGTGATCGAGTCACCCGTGTGGATGCCCATTGGGT
CGAAGTTTTCAATCGCACAGACGATGATGCAGTTATCGTTCTTATCACGCACCACTTCCATCTCGTACTC
TTTCCAACCAATCAGCGATTCATCGATCAGCAGTTCATTGGTCGGTGAAAGATCCAGACCGCGAGTACAG
ATTTCTTCAAACTCTTCACGGTTGTAAGCGATACCACCACCGCTGCCGCCCATGGTGAAAGAAGGACGGA
TGATACATGGGAAGCCGACCATATCGAGGACTTTGTACGCTTCTTCCATGCTTTTTGCGGTATCAGCGCG
AGGACACTCTAGGCCGATTGATTTCATCGCTTTATCAAAGCGTGAGCGGTCTTCCGCTTTATCAATCGCA
TCGGCGGTTGCGCCGATCATCTCAACGCCAAACTCAGCCAATACGCCATGTTTTTCGAGTGCCAGCGCAC
AGTTCAGCGCAGTCTGGCCGCCCATGGTGGGCAAAATCGCATCTGGGCGCTCTTTTTCGATGATCTTACG
CACCACTTCCCAGTGGATAGGCTCGATGTAAGTCGCATCGGCCATTTCTGGGTCAGTCATGATGGTCGCT
GGGTTTGAGTTAACCAGAATAACGCGGTAACCCTCTTCGCGCAGGGCTTTACACGCTTGCGCGCCTGAGT
AGTCAAACTCACAAGCCTGACCGATAACAATTGGACCCGCACCAAGGATAAGGATGCTTTGAATGTCAGT
ACGTTTTGGCA
Protein Sequence 
>gi|147673654|ref|YP_001217891.1| carbamoyl phosphate synthase large subunit [Vibrio cholerae O395] MPKRTDIQSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPEMADATYIEPIHWEVVRKIIEKERPDAILPTMGGQTALNCALALEKHGVLAEFGVEMIGATADAIDKAEDRSRFDKAMKSIGLECPRADTAKSMEEAYKVLDMVGFPCIIRPSFTMGGSGGGIAYNREEFEEICTRGLDLSPTNELLIDESLIGWKEYEMEVVRDKNDNCIIVCAIENFDPMGIHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVETGGSNVQFGINPKDGRMVIIEMNPRVSRSSALASKATGFPIAKVAAKLAVGFTLDELMNDITGGATPASFEPTIDYVVTKIPRFNFEKFAGANDRLTTQMKSVGEVMAIGRNQQESLQKALRGLEVGAAGLDEKVDLDAPDALTKIRYELKEAGAERIWYIADAFRAGMSVDGVFNLTNIDRWFLVQIEELVKLEAEVKAGGFAGLNQDVLRKMKRKGFSDARLSKLLGVSENEIRRLRDQYNIHPVYKRVDTCAAEFKSDTAYMYSTYDEECEANPTDKDKIMVLGGGPNRIGQGIEFDYCCVHAALALREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLAIVRVEKPKGVIVQYGGQTPLKLARALEAAGVPVIGTSPDAIDRAEDRERFQQAVQRLGLKQPDNATVTAIEQAIEKSREIGFPLVVRPSYVLGGRAMEIVYDEQDLRRYFNEAVSVSNESPVLLDRFLDDATEVDVDAICDGERVVIGGIMEHIEQAGVHSGDSACSLPAYTLSQEIQDKMREQVEKLAFELGVRGLMNIQFAVKDNEVYLIEVNPRAARTVPFVSKATGAPLAKIAARVMVGQTLEQQGFTKEIIPPYYSVKEVVLPFNKFPGVDPLLGPEMRSTGEVMGVGATFAEAYAKAELGCGSVYPEGGRALLSVREGDKQRVVDLASKLVKLGYQLDATHGTAVILGEAGINPRLVNKVHEGRPHILDRIKNHEYTYIVNTASGRQAIEDSKVLRRGALAHKVNYTTTLNAAFATCMSHTADAKASVTSVQELHARVKANQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: carB mutant is attenuated in mice (Merrell et al., 2002).
COG COG0458EF, under E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].