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cyaA from Vibrio cholerae O395

Victor ID 2331
Gene Name cyaA from Vibrio cholerae O395
Sequence Strain (Species/Organism) Vibrio cholerae O395
NCBI Gene ID 5135225
NCBI Protein GI 147673490
Locus Tag VC0395_A2397
Protein Accession YP_001218297.1
Taxonomy ID 345073
Chromosome No 2
Gene Starting Position 2550693
Gene Ending Position 2553224
Gene Strand (Orientation) -
Protein Name adenylate cyclase
DNA Sequence 
>gi|147673035:2550693-2553224 Vibrio cholerae O395 chromosome 2, complete sequence
GTTAGGCATTGACCACTTGCGAAGGCTTGGAATACACAGCGCTGTCGTTACGGTACGGCACCACGTACGT
TTCTCCCTCTTCAGGGTGGATGATTTGGTAATACTGCGGCAAGTTAAAATTGATGCTTTTCGCGCCGAGT
TTATTGCTGTCATCCAACATCGAGGTGTAGAAGCTGTTGACGCTGGCAATCATTTCGTCTTTTTCGCCAT
TAAACTGGTGATAGACTTCAACGCGGTTGGCCTCATCAAGCACATAGATGTTGAAACCTTTCTCGGTATC
TTCAAAGAAGAACTGCACCAAACCTTCACTGGCAAAACTATCCACCACCGCTGGCAATGGGTAATCTTGA
TCGCGATCGAGCATCAGTAAAGGCGAGCCCTTGAGCTTATTGGTTGAGATGCTGCGATAGAAATCAACCG
AGTTCTCCAACTTCTGAACCGAAACACCACGACGTTCAAAGAACAAACCATACATCTGATCGCCCATGCG
CAGCGCTTTGAAACGACGACGTTTCTCTTGCTCCATCGGCTTGAGGCGCAAATCGATACACTCAGCCAAC
AGTTGATAAACCAAGTTACGCATCACGCCGCGCAAGTTTTTGCTGTAGCAGAACACATCCACCGATTCTG
GCGGCAGCGCATCCTGATGCATTTTTCCAAGCACGGTTTTCAACGCATCAAGCATGGCCGTCTGGCCTTC
AAAATGCAGGGTACGCACTTCTTGCCACGAGTTGCGATACACCAAATCGACACTGCCGACTAAGCATTTC
TGCTCAGCACCAAAACTAAAAATATCGATATTTTTCAGGTCGACTTTCAGCGCTTTCCCACTCAATTCAC
TGGTTGGGTCGTGTTCAAAATTGATGAACATGGCAAGCTGGCTAATCTCACAAGGATTGGCCAGCGCTTG
CATAGTAGGGCGACGCTTACGCAGCGAAAAGGTATTACGCAGATCGCTGACCATTTGGTAGAACTTGTCG
ATGTCCAGCTGCGCTTCACGCACCACCGCATGCAAACGAGTCGACTCAGTGATCAGGCCATTAAAAAAGG
CCCAAGCCACCAATTTACTCAAGTATTCGTTGTGCTCAAGATACGGCTGACCAATCAAGCGCTGCGCCTG
CAGCGGCTGCTTGTAGAGATACCAACCGGGCTTATTGGTGCGTCCAGCACAAACCTCAATAAAACTTAAA
TCGGGCTCATGCAGGTCTGGGGAAATTTGTGGGTTGAGCAGTGTGACTTTCCCCGGCAGCACTTCAAACG
CCGCGTACAGTTTACGCGCCAAAATCGAGATATCTTGTGGGCTAATGGCCGAGGTGATGTCATTACGACG
CGCAAACTGGATCAGGTTACGATAGCTGAGCATCAAGGCATCAAGCAGTGCGTGGTGCACGACCTTCACT
TGCTCGACTTTCCAGTGACGACGGTTATCGAGCTCGGCAATCAAATCTGCGCTCCATTGCCATTCGCTGG
TCAGTTCCCGTAACGCTTCACGACGCCAAGGCATCGAGCCGACGCCCGGCTCACGCGACAACTTCTCATG
GGTTTTGAGATAGAAACAGCGGCGCACTAAATCAAGGCGCGTGCTATCACCAATTCGCACCAAATAGCGC
GTCACTTTCTCTAACATCTGATAGTAAGAGTCCATGCCGTACAGATCCGGTTCATCGGCAAAGAAACGGC
GTTTGCTGTCGATACTCAACAGTTGAGTGTGCGGGTACTCCCACGAATAGGCTTCAAGCAAAATGGCTTT
CAGTACCGATTTATAAGGCGAGTCAATGCTCTTATACAGTTGCCACAAGTTCGCGCCAAAGTACTCTTCA
GCCGGAATGCGGTTTAACTTGCCAAAATCGATCCATTCATTGCAGTTCAAATACCCATTTGAACAGAGCT
CGTGAACATATTCGTCGTAGCACTCTTCCATTTCTGGTGGCACGATTTGCCACAGCAGTCGCTTGCCCGC
TAAGCGCACCGCAGAGCGATAAAACTCATCCAATAATAATAAGTGCTGTGATGAACCACAGTTTTCACCG
CTTAACGCTTCGGAATGGTTATGGCGAAAACGCTCTTCATTCATGATGAAGAAATTGGCTTCAACACCCT
GACTTTTCGCCCAATCGGTAATGAGCAGACATTTACTGGAGAGGTTGTCGCGCGCCTCACAACTCATTTG
AGCAGAGACACAGACCCAAATATCCAGATCGCTCGATGTGCTTTGACCGATCGATGAGGTACTGCCCATC
GTATACAAGCCTAAAATCGCCGGATTGTCAGCTGGCGTTAACGGCTCGCCGAGCGTCAACTGAGCATCAT
CGATGAATTGCTGCTGGATAGGATTGGCTTCAAACAGATGGATACCGAAAGGCGTATCAGCAGAAAAATA
ACCGGGGATCAGAGGATGATTAAATTGAAATAGTGCGGGAATGAGGTGGAAAACACGTTGACTTTGCAAA
TCCATAAGAGCCAGCGCACGCTCAATACGTTGCCGGTTTAGCTTATCAAGTCTATGGATTAAGGTCTGAG
TATAAGCCTGCA
Protein Sequence 
>gi|147673490|ref|YP_001218297.1| adenylate cyclase [Vibrio cholerae O395] MQAYTQTLIHRLDKLNRQRIERALALMDLQSQRVFHLIPALFQFNHPLIPGYFSADTPFGIHLFEANPIQQQFIDDAQLTLGEPLTPADNPAILGLYTMGSTSSIGQSTSSDLDIWVCVSAQMSCEARDNLSSKCLLITDWAKSQGVEANFFIMNEERFRHNHSEALSGENCGSSQHLLLLDEFYRSAVRLAGKRLLWQIVPPEMEECYDEYVHELCSNGYLNCNEWIDFGKLNRIPAEEYFGANLWQLYKSIDSPYKSVLKAILLEAYSWEYPHTQLLSIDSKRRFFADEPDLYGMDSYYQMLEKVTRYLVRIGDSTRLDLVRRCFYLKTHEKLSREPGVGSMPWRREALRELTSEWQWSADLIAELDNRRHWKVEQVKVVHHALLDALMLSYRNLIQFARRNDITSAISPQDISILARKLYAAFEVLPGKVTLLNPQISPDLHEPDLSFIEVCAGRTNKPGWYLYKQPLQAQRLIGQPYLEHNEYLSKLVAWAFFNGLITESTRLHAVVREAQLDIDKFYQMVSDLRNTFSLRKRRPTMQALANPCEISQLAMFINFEHDPTSELSGKALKVDLKNIDIFSFGAEQKCLVGSVDLVYRNSWQEVRTLHFEGQTAMLDALKTVLGKMHQDALPPESVDVFCYSKNLRGVMRNLVYQLLAECIDLRLKPMEQEKRRRFKALRMGDQMYGLFFERRGVSVQKLENSVDFYRSISTNKLKGSPLLMLDRDQDYPLPAVVDSFASEGLVQFFFEDTEKGFNIYVLDEANRVEVYHQFNGEKDEMIASVNSFYTSMLDDSNKLGAKSINFNLPQYYQIIHPEEGETYVVPYRNDSAVYSKPSQVVNA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cyaA mutant is attenuated in mice (Merrell et al., 2002).
COG COG3072F, under F: Nucleotide transport and metabolism
References
Merrell et al., 2002: Merrell DS, Hava DL, Camilli A. Identification of novel factors involved in colonization and acid tolerance of Vibrio cholerae. Molecular microbiology. 2002; 43(6); 1471-1491. [PubMed: 11952899].