Victors

BMAA0649
Victor ID	2024
Gene Name	BMAA0649
Sequence Strain (Species/Organism)	Burkholderia mallei ATCC 23344
NCBI Gene ID	3086328
NCBI Protein GI	53717435
Locus Tag	BMAA0649
Genbank Accession	CP000011
Protein Accession	YP_105401
Other Database IDs	UniProtKB-ID: Q62D27_BURMA UniRef100: UniRef100_C4ANJ9 UniRef90: UniRef90_C4ANJ9 UniRef50: UniRef50_A2RY59 UniParc: UPI0000441282 EMBL: CP000011 EMBL-CDS: AAU46975.1 RefSeq_NT: NC_006349.2 GenomeReviews: CP000011_GR KEGG: bma:BMAA0649 TIGR: BMAA0649 HOGENOM: HBG757231 OMA: SISANAC ProtClustDB: CLSK709263 BioCyc: BMAL243160:BMA_A0649-MONOMER
Taxonomy ID	243160
Chromosome No	2
Gene Starting Position	658367
Gene Ending Position	662974
Gene Strand (Orientation)	+
Protein Name	hemagluttinin motif-containing protein
Protein pI	4.32
Protein Weight	131566.88
Protein Length	1535
Protein Note	identified by match to protein family HMM PF03895; match to protein family HMM PF05658; match to protein family HMM PF05662
DNA Sequence	>gi\|77358719:658367-662974 Burkholderia mallei ATCC 23344 chromosome 2, complete sequence GATGATTCCGCTTGCAATAGCCGTGGCTCTGATGTTTTCACCCTACGCATGGGCGGGTGTCGGCGGAGCC GACAACGGCGTGACGGGGACGAGCAACAACGGCGGGGTAGGCGGATCGTCCGGCGGCGGCGGTGTCCAGT TCAGCGACATGGGCGTGGCCTTTGTCGGCGATGGCGACTGCTCGATGCTCACGTCCGGGCCGGGATCGTA TGCCGGCGTATACGGTTCGGGGAGCAATTATCTGGGCGGCCTGTTCGGCTTCGGCGCACAGACGTCGGCC GTCGGCTGGGGGACGCCCAGCAACGCCGGCGCCAACAGCGGTATCGTCCCATACCAGGGCGCCGCTCAAA CCTTCGGCAACGTCACCTATGCCGGCAACGGCACGCAGAGCGGCAACTTCACGCAGGCGTTCGGCCTGAA TTCCTTTGCGGTCGGCTGCGGCGCTCACGCGACCGGCCTGAGCGCGACGGCGATCGGCTGGGGAACCACC GCGAGCGGCGCCGGAAGCGTCGCGCTCGGGCTGTACAGCACCGCGAGCGGCCAGGGATCGTTGGCGTTCG GCACCAGCGCGACGGCGACGGCCACCGACACCATCGCGCTCGGCACGCTGGCCACGGCCAACGCGGTCAG CGGCGTGGCGATCGGCGCGAACACGCAGGCTTCGGCCGCCAATGCAACCGCGATCGGCGGCAATTCATCC GGCGCCAACCTCGGCGCGCAGGCGACGGCGGCCGGCGCCACCGCGATCGGCGGCAACGCGACGGCCGGGG CCGCCGCGACGGCGACGAACGCCATCGCGATCGGCGGGCAGTCGTCGGCGAAGGATACGAACGATGTGGC CGTGGGCCTGGGCGCGAGGGCCGGCACGGGAAGCGGCGCGGGCAACGATCTCGCGATCGGCAATGGCGCG ACGGCCACGGGCGGCAATTCGATCGCCCAGGGCGCGGGCGCGAGCGCCAATGCGGCCGGCGCGGTGGCCA TCGGCAAATCGGCGTCCGCCGCCGGCGGGCAAGCCGTTTCGATCGGCGTGGCCAATACCGCGTCGGGCAA CGGCGCGGTGGCGATCGGCGATCCGAACGTCGCGACCGGAACCGGCGCTGTCGCACTGGGCAACAACAAT ACGGCCAATGGTCAAGGCGCGGTGGCGCTGGGCAATGTCAGCACGGCGGTCGGCCAAGGCAGCGTGGCGC TCGGCAACAGCAGCAATGCGGCCGCGGCGGGCGGAGTGGCCTTGGGCGATACCGCGAGCGCGGTGATGGC GGGCGGCTTGGCACTCGGCTCGCTCGCGACGGCGAGCAATGCGAACGACGTGGCGCTCGGCGCGGGTTCG AAAACCGCCGCGGCAGTCGCGACGTCCACGGTTTCGGTGAACGGCGCGAACTACGCGGTGGCGGGAAGCG GCCCGGCCAGCACGGTCAGCGTGGGTGCGCCGGGCAGCGAGCGCACGATCACCAATGTGGCCGCGGGTCA AGTAAGCGCCGGTTCCACCGATGCGGTGAATGGTTCGGAACTGTACGCGACGAACCAGGCAATCACGACC GGATTGTCGACAGCGAACAGCAGCATCGCGTCGCTGTCCACGTCGACGTCGACGGGTCTTTCGAGCGCCA ACAGCAACATCGGCTCGTTGTCGACGGGTTTGTCGACCGCCAACAGCACGGTTGCGTCGTTGTCGAGTTC CACGTCGACGGGGCTGTCCTCAGCCAATAGCGCGGTGGCGTCACTGTCCACGTCGACGTCGACGGGTCTT TCGAGCGCCAACAGCAACATCGGCTCGTTGTCGACAGGTTTGTCGACCGCCAACAGCACGGTTGCGTCGT TGTCGACGTCCACGGTTGCCGGCCTGAATTCGCTGTCCACCGGATTGAGCACGACCAATAGCAATGTCGC GTCGCTGTCGAGTTCCACGTCGACGGGATTGTCCTCGGCCAATAGCGCGGTGGCGTCGCTGTCCACGTCG ACGTCGACGGGTCTTTCGAGCGCCAACAGCAACATCGGCTCGTTGTCGACGGGTTTGTCGACCACGAACA GCACGGTTGCGTCGTTGTCGAGCTCGACGTCGACCGGTATCGGTTCGTTGTCGACGGGGGTGGCCAATTC TGTCCAGTATGACAGTCCTGCTCATACGTCCATTACCCTGGGTGGCGCCAGTGCAACGTCACCCGTGAAG ATCACTAATTTGGCGGCGGGCGCGAACCCGAGCGATGCCGTCAACTATGAGCAACTGACATCGCTGTCGA CGTCGGCGTCGACGGGGCTGTCGTCGGCCAACAGCGCGATCACGTCGCTATCCACCTCGACGTCGACCGG CATCGGCTCGTTGTCCACCGGGTTGAGCACGACCAACAGCAACGTCGCGTCGTTGTCGACGTCGGCGTCG ACGGGACTGTCGTCGGCCAACAGCGCGATCACGTCGCTATCCACCTCGACGTCGACCGGCATCGGCTCGC TGTCCACCGGACTGAGCACGACCAACAGCAACGTCGCATCGTTGTCGACGTCGGCGTCGACGGGACTGTC GTCGGCCAACAGCGCGATCACATCGCTATCCACCTCGACGTCGACCGGCATCGGTTCGCTGTCCACCGGA CTGAGCACGACCAACAGCAACGTCGCGTCGCTGTCGACGTCGGCGTCGACGGGACTGTCGTCGGCCATCA GCGCGATCACGTCGCTGTCCACCTCGACGTCGACCGGTATCGGCTCGCTGTCCACCGGGTTGAGCACGAC CAACAGCAACGTCGCGTCGTTGTCGACGTCGGCGTCGACGGGACTGTCGTCGGCCAACAGCGCGATCACG TCGCTGTCCACCTCGACGTCGACCGGCATCGGTTCGCTGTCCACCGGGCTGAGCACGACCAACAGCAACC TGAGCTCCCTGTCCACGTCGAGCTCGACCGGCCTGAGTACGGCCAACAGCAACATCTCGTCGCTGTCCAC CGGGCTGAATTCGTTGTCGACCGCGGTCAACGGCGGCGGGACGAAGTACTTCCACGCCAACTCGACGCAG CCGGACAGTCAGGCGCTGGGGGCGGATTCCGTCGCGGTCGGGCCGGCGGCCATCGCGGCGGGCGCAAGCG GCATTGCGATCGGCAATGCGGCGAACGCGGCCGCCAACGGCGCCGTCGCGATCGGCCAGGCCGCCGTCGC GAAGGGCGGGCTGGCTGTCTCGATCGGGGTGTCGAACACGGCGAGCGGAGACGGCGCGGTGGCGATCGGC GATCCGAACGTCGCGACCGGCACCGGCGCGGTCGCGCTTGGCGCGGACAATTCGGCAAACGGCCAGGGCG CCGTCGCGCTCGGCAACGCGAACATCGCAACCGGAACGGGCTCGCTTGCGTTCGGCAACACGTCGACGGC GGCAGCGGCGGGCGCGGTCGCGTTGGGCGCCGGCGCAATCGCGAACAATGCGAACGATGTCGCGCTGGGT TCCGCTAGCGTGACCGCGGCTGCGAATCCGGTGGCCAGCGCGTTGATCGCAGGTCAGGCTTATTCGCTTG CCGGCGGCGCGCCGGCGAGCGTGGTGAGCGTCGGCGCGCCCGGCGCCGAACGGCAAATCACCAACGTCGC GGCCGGGCGGATTTCCGCCACGTCGACCGATGCGGTGAACGGCTCGCAGATGAATGCGATGACTCAGGCG CTGGAATCGCTGTCGACTTCGACGGCCAGCGCGCTGTCCACGGCGCAAAGCGGTCTGGGTTCGTTGTCGA CGGGGCTCAGCTCGACGCAGAGCAGCGTGAGTTCGCTGTCGACGGGGCTCAGCACGACGAGCGGCAATGT GGCGTCGCTGTCGAGCGGTCTGGGCACGATGCAAAGCGGTATCGCGTCGCTGTCCACGGGGCTGAGCACG ACGAACAGCAGCCTCGCGTCGCTGTCGACCGCCGTGTCCGGCGGCGGTGTTCGCACCAGCAGCTTGGGCG ACACGTCGGCGGGCAATGGCGCGAACGCGTCCGGCGGCAACGGCACGGCGGTCGGCGGCGCCGCGTCCGC TTCGGGAACCGATGCGACCGCGCTGGGCCAGGCGTCGAACGCGTCGGGCAATCATTCGACCGCATTGGGG CAAGCATCGAGCGCGTCCGGAAGCGGCTCCACCGCGGTGGGACAAGGCGCCGGCGCGCCCGGCGACGGCG CTTCGGCATTCGGCCAAGGGGCACTTGCCTCCGGTACGGACTCGACGGCGCTCGGCGCTCATTCGACGGC TGCGGCGCCGAACTCGGCGGCGATCGGCGCGAATTCGGTGGCGTCCGCGCCGAATTCGGTGTCGTTCGGT TCGCGGGGCCATGAGCGCAGGCTGACGAATGTCGCGCCGGGGATCGACGGCACCGACGCGGCGAACATGA ACCAGCTCTGGGGCGTGCAATCGAGCGTCGATCAGGCGGCGCGCCGCGCCTATTCCGGGGTGGCGGCCGC GACCGCGCTGACGATGATTCCGGAGGTCGACCCCGGCAAGACGATCGCGGTCGGGATCGGCGCGGGCAGC TATCAAGGGTATTCGGCGTCCGCGATCGGCGTGTCCGTGCGGTTCTCCGACAACCTGAAGGCGAAGCTCG GCGTGGGGATCAGCGCTCAGGGCAGCACATATGGCGCAGGCGTCTCGTACCAGTGGTA
Protein Sequence	>gi\|53717435\|ref\|YP_105401.1\| hemagluttinin motif-containing protein [Burkholderia mallei ATCC 23344] MIPLAIAVALMFSPYAWAGVGGADNGVTGTSNNGGVGGSSGGGGVQFSDMGVAFVGDGDCSMLTSGPGSY AGVYGSGSNYLGGLFGFGAQTSAVGWGTPSNAGANSGIVPYQGAAQTFGNVTYAGNGTQSGNFTQAFGLN SFAVGCGAHATGLSATAIGWGTTASGAGSVALGLYSTASGQGSLAFGTSATATATDTIALGTLATANAVS GVAIGANTQASAANATAIGGNSSGANLGAQATAAGATAIGGNATAGAAATATNAIAIGGQSSAKDTNDVA VGLGARAGTGSGAGNDLAIGNGATATGGNSIAQGAGASANAAGAVAIGKSASAAGGQAVSIGVANTASGN GAVAIGDPNVATGTGAVALGNNNTANGQGAVALGNVSTAVGQGSVALGNSSNAAAAGGVALGDTASAVMA GGLALGSLATASNANDVALGAGSKTAAAVATSTVSVNGANYAVAGSGPASTVSVGAPGSERTITNVAAGQ VSAGSTDAVNGSELYATNQAITTGLSTANSSIASLSTSTSTGLSSANSNIGSLSTGLSTANSTVASLSSS TSTGLSSANSAVASLSTSTSTGLSSANSNIGSLSTGLSTANSTVASLSTSTVAGLNSLSTGLSTTNSNVA SLSSSTSTGLSSANSAVASLSTSTSTGLSSANSNIGSLSTGLSTTNSTVASLSSSTSTGIGSLSTGVANS VQYDSPAHTSITLGGASATSPVKITNLAAGANPSDAVNYEQLTSLSTSASTGLSSANSAITSLSTSTSTG IGSLSTGLSTTNSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLS SANSAITSLSTSTSTGIGSLSTGLSTTNSNVASLSTSASTGLSSAISAITSLSTSTSTGIGSLSTGLSTT NSNVASLSTSASTGLSSANSAITSLSTSTSTGIGSLSTGLSTTNSNLSSLSTSSSTGLSTANSNISSLST GLNSLSTAVNGGGTKYFHANSTQPDSQALGADSVAVGPAAIAAGASGIAIGNAANAAANGAVAIGQAAVA KGGLAVSIGVSNTASGDGAVAIGDPNVATGTGAVALGADNSANGQGAVALGNANIATGTGSLAFGNTSTA AAAGAVALGAGAIANNANDVALGSASVTAAANPVASALIAGQAYSLAGGAPASVVSVGAPGAERQITNVA AGRISATSTDAVNGSQMNAMTQALESLSTSTASALSTAQSGLGSLSTGLSSTQSSVSSLSTGLSTTSGNV ASLSSGLGTMQSGIASLSTGLSTTNSSLASLSTAVSGGGVRTSSLGDTSAGNGANASGGNGTAVGGAASA SGTDATALGQASNASGNHSTALGQASSASGSGSTAVGQGAGAPGDGASAFGQGALASGTDSTALGAHSTA AAPNSAAIGANSVASAPNSVSFGSRGHERRLTNVAPGIDGTDAANMNQLWGVQSSVDQAARRAYSGVAAA TALTMIPEVDPGKTIAVGIGAGSYQGYSASAIGVSVRFSDNLKAKLGVGISAQGSTYGAGVSYQW
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: boaA (BMAA0649) mutant has reduced adherence to human epithelial cell lines, specifically HEp2 (laryngeal cells) and A549 (type II pneumocytes), as well as to cultures of normal human bronchial epithelium (NHBE) compared to the wild type (Balder et al., 2010).
References	*Balder et al., 2010:* Balder R, Lipski S, Lazarus JJ, Grose W, Wooten RM, Hogan RJ, Woods DE, Lafontaine ER. Identification of Burkholderia mallei and Burkholderia pseudomallei adhesins for human respiratory epithelial cells. BMC microbiology. 2010; 10; 250. [PubMed: 20920184].


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BMAA0649