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cgd6_1760

Victor ID 2019
Gene Name cgd6_1760
Sequence Strain (Species/Organism) Cryptosporidium parvum
NCBI Gene ID 3376122
NCBI Protein GI 66475452
Locus Tag cgd6_1760
Protein Accession XP_627542.1
Other Database IDs UniProtKB-ID: Q5CXB2_CRYPV
UniRef100: UniRef100_Q5CXB2
UniRef90: UniRef90_Q5CXB2
UniRef50: UniRef50_Q5CXB2
UniParc: UPI00001ADBD7
EMBL: AAEE01000002
EMBL-CDS: EAK89843.1
RefSeq_NT: XM_627542.1
KEGG: cpv:cgd6_1760
EuPathDB: CryptoDB:cgd6_1760
ProtClustDB: CLSZ2496818
Taxonomy ID 353152
Chromosome No 6
Gene Starting Position 416875
Gene Ending Position 419706
Gene Strand (Orientation) -
Protein Name phosphatidylinositol 3-kinase; PI3ka plus PI3Kc domains
DNA Sequence 
>gi|66671299:416875-419706 Cryptosporidium parvum Iowa II chromosome 6, whole genome shotgun sequence
TTTAGGCCCAGTAGAGAGCCCAATCATGAAGAGTATCAACAACTGCGGGAAAAAGTGCATTTGATGACGT
CATAATTATTTCTCTTAAATACCTTTCTGCCTCTTTTTCTGATTGATCCAACCTGAACTTATCTTTAATT
CTTTCCAAAATAGCTGTATAGTTGTTTTCAGGTCTTGAATTGAGATCCTTTATACTACTATCAACCATCA
ATAACAAAACATTTAATATTAGCCATGACTTCCTGCGAATATACCTATAATAATCGCAGCATTTGTCAAC
AAAAAGCTTGAATCCTAATGAGTTTAATCCGCCCATAGCTTCTATCATTTCTGAACAAATTTTCATTGGT
GGTGGGAAAGGTTTCGGATCTTCTCCAAATATATATCCAAAATCAACATGTAAAAAGTGGCCGCTTTTCC
CGACCAGTAGATTATCAAGATGCCGATCTCCAACACCAAGTATAAATGTAATAACGCTATATGCTGCGCA
ACTAGTTATAAAGGTGGTTAGAACATTATGAGGAATATTGTTTATGTTAGTTTTATATGCATTTGCCCAA
TAATTCAATATGCAATTTTTTCCATATTTTTTTCTGATTGATCCGATTGAAGAAAAATCGTCAAGAAATT
CAATTAATCCATCAAATTGCGAAAACGGCGTAACTTTATATGTGATAATTGAACTGTTCGCATTCCATTC
GTTAAGTAGCTTATAAGATATCTCCAAAAGTTGTACAACTAATCTATCTTGTCTCAAATCATCCCCCACC
TTGTACATATATTTTGATTCAACTACAGGATATATTGATTCGGATGTGTAAATATCCTCTCTCGGAACAT
TTGCCTGACTATTTTCTTTTTTGCTATTATTGACAATTGCCATTCTACAAGAAAATATAATTGGGCATTG
AGAAGACTTGATAATAAAACTTTCGCTTGGAACAATACCAATTAACGCTCTATTAACATCAATTGGAAGT
AGAAGAAGATCACTCAAGTTCGTTATATTTAACAATGGCAGCTCAATTCCCTCGATTTTTGAAGGAAGAC
CCTTTAAACTTTCAATATTGTGACTACTAACAAATTTTAAAGAAAGTAAGTTTCTTTTTTTGCTACAATA
ATTCGAAAATTCGCTTTCAACTTTTAACATTAATTTGATCGAGTTGATTAATTTAACAGTTATTTTATCT
ATACCTGTTGAACGTGAAGAAATCTTTGATTGAGAATAAGGCATCTTTCCTAGTTCAAAATCGCTCAATA
TACTTTGAAATTTTTGTATTTTTTTCTCTGCTCTTTCTCTCTTACAGTCTTCAACTGAAATACGATGTAT
CCATAACAACGTTGCTCTAAATTGTATCTGGCAAAGAATTAGATCAATTATTTCTAAACAGAAATGATAT
TTACAGCAATGAGATTCCTCCATACTTTCTTTAATATTATAATTATTATAATCAGCAAGGCCATCAACTA
TTTCGAATATTGTCTGCTCAAAGACTTTAGGATATTCTTGAATTGAAATTTCCGAAATTAACAACCAAAA
TAATTCAACACAAAATTCTAGATCGCATGTTGCTTTTCTTTTTAGAAACTTCATGAGCTCAGTTCCATTT
TCATATCTAAGAGACTGAACCAGTTGTGGTAGAACAAGAAATAACTCTTCTTTTGTGCAAAATTCCAAGC
TTTCTATTGCAAGCTTGCGAATATTCAAGAACTCCTTATATTTTCTTGAAAGCAAATTTAACGAGTCTTC
AATATTCAAAATTCTTTTTTTATGAGTATCAATCGGTTCTTTAATTGTTTGAATGATTGAGCTGATTAAA
TAATCAATTTCAACCATTATTTCTTTATCGCTTAAATTAATAAAATGAAACAACATAGGTATTCCTGCCT
TAAATCTGAATAAATAAAACCTGTATTTCCAGATCAATCCAACCTCATCCTCATATAAGTCTGTATTATT
GAACTTTGTAATATATCCTATATATAATTGATTTATTGCTCTTTCTAACTCCAACCTCTCTTTATTCATT
AAATAATTATTAATTAATGAATTCTCCACAGAAAAACAAGGTAAACGATCTATTGAACATTTGTTATTAT
TCATTAGAAGACTGAAATCAATTCTTTTCCCCGAATCTCCAACAGTTGATAGATTTATGTGATCCGAAAT
AATATTAAAAATGCAACTAGAATTAATTATTTGTTTTGTATTCAAAACGTTTTTATTGGCCATTATGTAA
GAAACCTTCTTTTCTTTAAAGTTAAATGATAAGCGTAAATAACCAAGTAATTTATCGCTAAATTTGCTCA
AATAAATGTCATCTTGAAATTTATTTTCTTGTGGGAAAAGTATTTCATATATTTGTGCATTCAAATCAAA
AATTAATTTTTCCTCGAATACCCCCGAAAAGTTTATTAGAATAGGTAAGTTAATAGATGAAAGTTTTTCA
GTGTAATAAGCCGAAACCAAAGGAAGTATGGAGTACCCGAGTACAAATTCTCCATTACCAAGGTAATTTT
CATCTAACAGTTTAAAAATATAGACATTAGTATAGTTGCAAAGCGATGAAAAATTAACTGCTCCGCAATT
AGGCAAGCCAATCTCACAATTAACACATATCTTCTCACTTTTTTTATTTATGTTTTTATCAATTACAATC
AGCTGCGATTGAATTGCAGTTTTACTATCTGAAATGATTTTTCCGGATGAATTTATTAAGTATTGCTCAC
AATGAACTCTTAGTGCAATTGGAAAGTATTTCATATTCATGAGCGAATATTTACTTTGTATTTTCTCAAA
TGAGAATGCAATGTAGTCTATGTTAACATTCA
Protein Sequence 
>gi|66475452|ref|XP_627542.1| phosphatidylinositol 3-kinase; PI3ka plus PI3Kc domains [Cryptosporidium parvum Iowa II] MNVNIDYIAFSFEKIQSKYSLMNMKYFPIALRVHCEQYLINSSGKIISDSKTAIQSQLIVIDKNINKKSEKICVNCEIGLPNCGAVNFSSLCNYTNVYIFKLLDENYLGNGEFVLGYSILPLVSAYYTEKLSSINLPILINFSGVFEEKLIFDLNAQIYEILFPQENKFQDDIYLSKFSDKLLGYLRLSFNFKEKKVSYIMANKNVLNTKQIINSSCIFNIISDHINLSTVGDSGKRIDFSLLMNNNKCSIDRLPCFSVENSLINNYLMNKERLELERAINQLYIGYITKFNNTDLYEDEVGLIWKYRFYLFRFKAGIPMLFHFINLSDKEIMVEIDYLISSIIQTIKEPIDTHKKRILNIEDSLNLLSRKYKEFLNIRKLAIESLEFCTKEELFLVLPQLVQSLRYENGTELMKFLKRKATCDLEFCVELFWLLISEISIQEYPKVFEQTIFEIVDGLADYNNYNIKESMEESHCCKYHFCLEIIDLILCQIQFRATLLWIHRISVEDCKRERAEKKIQKFQSILSDFELGKMPYSQSKISSRSTGIDKITVKLINSIKLMLKVESEFSNYCSKKRNLLSLKFVSSHNIESLKGLPSKIEGIELPLLNITNLSDLLLLPIDVNRALIGIVPSESFIIKSSQCPIIFSCRMAIVNNSKKENSQANVPREDIYTSESIYPVVESKYMYKVGDDLRQDRLVVQLLEISYKLLNEWNANSSIITYKVTPFSQFDGLIEFLDDFSSIGSIRKKYGKNCILNYWANAYKTNINNIPHNVLTTFITSCAAYSVITFILGVGDRHLDNLLVGKSGHFLHVDFGYIFGEDPKPFPPPMKICSEMIEAMGGLNSLGFKLFVDKCCDYYRYIRRKSWLILNVLLLMVDSSIKDLNSRPENNYTAILERIKDKFRLDQSEKEAERYLREIIMTSSNALFPAVVDTLHDWALYWA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: P13K mutant is attenuated in invasion of H69 cells (Chen et al., 2004).
References
Chen et al., 2004: Chen XM, Splinter PL, Tietz PS, Huang BQ, Billadeau DD, LaRusso NF. Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42. The Journal of biological chemistry. 2004; 279(30); 31671-31678. [PubMed: 15133042].