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ilvI

Victor ID 2009
Gene Name ilvI
Sequence Strain (Species/Organism) Burkholderia pseudomallei K96243
NCBI Gene ID 3093947
NCBI Protein GI 53718832
Locus Tag BPSL1196
Genbank Accession HB949671
Protein Accession YP_107818
Other Database IDs UniProtKB-ID: Q63VP8_BURPS
UniRef100: UniRef100_C4KU51
UniRef90: UniRef90_A0K939
UniRef50: UniRef50_P57321
UniParc: UPI000043AEF0
EMBL: BX571965
EMBL-CDS: CAH35191.1
RefSeq_NT: NC_006350.1
GenomeReviews: BX571965_GR
KEGG: bps:BPSL1196
HOGENOM: HBG323037
OMA: GAMNEMW
ProtClustDB: PRK06965
BioCyc: BPSE272560:BPSL1196-MONOMER
Taxonomy ID 272560
Chromosome No 1
Gene Starting Position 1379162
Gene Ending Position 1380925
Gene Strand (Orientation) +
Protein Name acetolactate synthase 3 catalytic subunit
Protein pI 6.63
Protein Weight 60302.3
Protein Length 587
Protein Note acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
DNA Sequence 
>gi|53717639:1379162-1380925 Burkholderia pseudomallei K96243 chromosome chromosome 1, complete sequence
GATGAACATGCCCAGCGCGGAATTCTCCACGTCGGAATCCCTTTCCCCTCAGAAAACCGGCTCCATCGGC
GCCACCGTGCTCATGAAGGCACTGGCCGACGAGAACGTCGAATTCATCTGGGGCTACCCTGGCGGCTCGG
TCCTCTACATCTACGACGAGCTGTACAAGCAAGACAAGATTCAACACGTGCTCGTGCGCCACGAGCAGGC
CGCCGTGCACGCCGCGGACGCGTACTCGCGCTCGACGGGCAAGGTCGGCGTGTGTCTCGTCACATCCGGC
CCGGGCGTGACGAACGCGGTGACGGGCATCGCCACCGCCTACATGGATTCGATCCCGCTCGTCGTGATCA
GCGGCCAGGTGCCGACCGCGGCGATCGGCCAGGACGCGTTCCAGGAGTGCGATACCGTCGGCATCACGCG
GCCGTGCGTGAAGCACAATTTCCTCGTGAAGGACGTGCGCGAGCTCGCGCAAACCGTCAAGAAGGCGTTC
TACATCGCGCGTACCGGCCGGCCCGGTCCGGTCCTCATCGACATCCCGAAGGACATCTCGAAGACGCCGT
GCGAGTACGAGCCCGTCAAGAACGTGTCGCTGCGCTCGTACAACCCGGTCACGAAAGGCCATTCGGGGCA
GATCCGCAAGGCGGTGTCGCTGCTGCTGTCCGCGAAGCGTCCGTACATCTACACGGGCGGCGGCATCATC
CTCGCCGACGCGTCGCGCGAGCTGAACCAGTTCGCCGACCTGCTCGGCTATCCCGTCACGAACACGCTGA
TGGGCCTCGGCGGCTATCGCTCGTCGGACAGGAAATTCCTCGGCATGCTCGGCATGCACGGCACCTACGA
AGCGAACATGGCGATGCAGCACTGCGACGTGTTGATCGCGATCGGCGCGCGCTTCGACGACCGCGTGATC
GGCGATCCGGCGCACTTCGCGTCGCGCCCGCGCAAGATCATCCATATCGACATCGATCCGTCGTCGATCT
CGAAGCGCGTGAAGGTCGACATCCCGATCGTCGGCGACGTGAAGGAAGTGCTCAAGGAGCTGATCGAGCA
GTTGCAGACGGCCGAGCACGGCCCGGACGCCGACGCGCTCGCGCAGTGGTGGAAGGAAATCGAAGGCTGG
CGCGGGACGGATTGCCTGAAGTACGACCGCGCGAGCGAGATCATCAAGCCGCAATACGTCGTCGAGAAGC
TCTGGGAGCTCACCGACGGCAACGCGTTCGTTTGCTCGGACGTCGGCCAGCACCAGATGTGGGCCGCGCA
GTTCTACCGCTTCAACAAGCCGCGCCGCTGGATCAACTCGGGCGGCCTCGGCACGATGGGCTTCGGCCTG
CCCGCCGCGATGGGCGTCAAGATGGCGCACCCGGACGACGACGTCGTCTGCATCACGGGCGAGGGCTCGA
TCCAGATGTGCATCCAGGAGCTGTCGACCTGCAAGCAGTACGACACTCCGGTGAAGATCATTTCGCTGAA
CAACCGCTACCTCGGCATGGTCCGCCAATGGCAGCAGATCGAATACAGCAAGCGCTATTCGCATTCGTAC
ATGGATGCGCTGCCCGATTTCGTGAAGCTCGCGCAGGCGTACGGCCATATCGGGATGCGCATCGAAAAAT
CCGCGGACGTCGAGCCGGCGCTCAAGGAAGCGCTGAGCCTGAAGGACCGCACCGTGTTTCTCGACTTCCA
GACCGACCCCACCGAGAACGTCTGGCCGATGGTCCAGGCCGGCAAGGGCATCACCGAGATGCTGCTCGGA
TCGGAAGATCTGTA
Protein Sequence 
>gi|53718832|ref|YP_107818.1| acetolactate synthase 3 catalytic subunit [Burkholderia pseudomallei K96243]
MNMPSAEFSTSESLSPQKTGSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKIQHVLVRHEQA
AVHAADAYSRSTGKVGVCLVTSGPGVTNAVTGIATAYMDSIPLVVISGQVPTAAIGQDAFQECDTVGITR
PCVKHNFLVKDVRELAQTVKKAFYIARTGRPGPVLIDIPKDISKTPCEYEPVKNVSLRSYNPVTKGHSGQ
IRKAVSLLLSAKRPYIYTGGGIILADASRELNQFADLLGYPVTNTLMGLGGYRSSDRKFLGMLGMHGTYE
ANMAMQHCDVLIAIGARFDDRVIGDPAHFASRPRKIIHIDIDPSSISKRVKVDIPIVGDVKEVLKELIEQ
LQTAEHGPDADALAQWWKEIEGWRGTDCLKYDRASEIIKPQYVVEKLWELTDGNAFVCSDVGQHQMWAAQ
FYRFNKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQYDTPVKIISLN
NRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAQAYGHIGMRIEKSADVEPALKEALSLKDRTVFLDFQ
TDPTENVWPMVQAGKGITEMLLGSEDL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ilvI mutant is attenuated in mice (Atkins et al., 2002).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Atkins et al., 2002: Atkins T, Prior RG, Mack K, Russell P, Nelson M, Oyston PC, Dougan G, Titball RW. A mutant of Burkholderia pseudomallei, auxotrophic in the branched chain amino acid biosynthetic pathway, is attenuated and protective in a murine model of melioidosis. Infection and immunity. 2002; 70(9); 5290-5294. [PubMed: 12183585].