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aroB

Victor ID 1999
Gene Name aroB
Sequence Strain (Species/Organism) Burkholderia pseudomallei K96243
NCBI Gene ID 3092462
NCBI Protein GI 53720775
Locus Tag BPSL3168
Genbank Accession BX571965
Protein Accession YP_109761
Other Database IDs UniProtKB-ID: AROB_BURPS
UniRef100: UniRef100_A3MPY1
UniRef90: UniRef90_B1YRS4
UniRef50: UniRef50_Q0AJ12
UniParc: UPI000043B657
EMBL: BX571965
EMBL-CDS: CAH37178.1
RefSeq_NT: NC_006350.1
GenomeReviews: BX571965_GR
KEGG: bps:BPSL3168
HOGENOM: HBG632303
OMA: CEIKAEV
ProtClustDB: PRK00002
BioCyc: BPSE272560:BPSL3168-MONOMER
Taxonomy ID 272560
Chromosome No 1
Gene Starting Position 3772906
Gene Ending Position 3773985
Gene Strand (Orientation) -
Protein Name 3-dehydroquinate synthase
Protein pI 5.8
Protein Weight 35117.37
Protein Length 359
Protein Note catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
DNA Sequence 
>gi|53717639:3772906-3773985 Burkholderia pseudomallei K96243 chromosome chromosome 1, complete sequence
TTTACCGGGTGGTTGCCGCCAGTGTCGCGAGAACGGCGTCGTCGGGCGCCGGAGTGATGATCGTTTCGCC
GAAGCGTTTGAGCAGTATGAACTTGATCGCGCCCGCCTCGGCCTTCTTGTCGACGCGCATCAGCTCGACA
TAACGCGCGTCGCCGAGATCCGGCGCGCGCGTCGGCAGATGCGCGGCCTCGACGACGCGGCACAGCCGCG
CGCGCGACGCTTCGTCGAGATGGCCGGTTCGCACCGACAGGTCGGCCGCCATCACCATGCCGCAGCCCAC
CGCCTCGCCGTGCAGCCACTCGCCGTAGCCGAGCCCCGCTTCGATCGCGTGCCCGAACGTATGGCCAAAA
TTGAGGATCGCGCGCAGACCGCCCTCGCGCTCGTCCGCCGCGACGACGCCCGCCTTGATCTCGCACGAGC
GCTTGACCGCGTGCGCAAGCGCGTCGGGATCGCGGCGAGTGAGCGCGCCCACGTTCGCCTCGATCCAGTC
GAAGAACGCGGCATCGGCGATCGCGCCCGTCTTGACGATCTCGGCGACGCCCGCGGCAAGCTCGCGATCG
GGCAGCGTCGACAGCGCGCCGATATCGGCGATCACCGCCTGCGGCTGATAGAACGCGCCGATCATGTTCT
TGCCGAGCGGATGGTTGATGCCCGTCTTGCCGCCGACCGACGAATCAACCTGCGACAGGAGCGTCGTCGG
CACCTGGATGAACGGCACGCCGCGCATGTAGCATGCGGCCGCGAAGCCCGTCATGTCGCCGATCACGCCG
CCGCCGAGCGCGATCAGCGTCGTCTTGCGATCGGCGTGCTGCTCGAGCAGGCCGTCGAAGATCAGATTGA
GCGTTTCCCAGTTCTTGTACGCTTCGCCGTCGGGCAGGACGACGGTCGACACGCGCTTGCCGAGCGGCGC
GAGCGCGGCGCGCAGCGTGTCGCCGTAGAGCGGCTCGACGGTGGTGTTCGTGACGATCGTGACGGATGCG
CCCGCGATGTGCGGCGCGAACAGCTCGGTGCGGCCGATCAGATCGGCGCCGATGTGGATCGGATAGGCGC
GCTCGCCCAGGTCGACGTTGACGGTAATCA
Protein Sequence 
>gi|53720775|ref|YP_109761.1| 3-dehydroquinate synthase [Burkholderia pseudomallei K96243]
MITVNVDLGERAYPIHIGADLIGRTELFAPHIAGASVTIVTNTTVEPLYGDTLRAALAPLGKRVSTVVLP
DGEAYKNWETLNLIFDGLLEQHADRKTTLIALGGGVIGDMTGFAAACYMRGVPFIQVPTTLLSQVDSSVG
GKTGINHPLGKNMIGAFYQPQAVIADIGALSTLPDRELAAGVAEIVKTGAIADAAFFDWIEANVGALTRR
DPDALAHAVKRSCEIKAGVVAADEREGGLRAILNFGHTFGHAIEAGLGYGEWLHGEAVGCGMVMAADLSV
RTGHLDEASRARLCRVVEAAHLPTRAPDLGDARYVELMRVDKKAEAGAIKFILLKRFGETIITPAPDDAV
LATLAATTR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: aroB mutant is attenuated in mice (Cuccui et al., 2007).
COG COG0337E, under E: Amino acid transport and metabolism
References
Cuccui et al., 2007: Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PC, Titball RW, Wren BW. Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infection and immunity. 2007; 75(3); 1186-1195. [PubMed: 17189432].