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BPSL1263

Victor ID 1992
Gene Name BPSL1263
Sequence Strain (Species/Organism) Burkholderia mallei
NCBI Gene ID 3091526
NCBI Protein GI 53718898
Locus Tag BPSL1263
Protein Accession YP_107884.1
Other Database IDs UniProtKB-ID: Q63VI2_BURPS
UniRef100: UniRef100_A3N7S9
UniRef90: UniRef90_A3N7S9
UniRef50: UniRef50_A9AD14
UniParc: UPI000043AF32
EMBL: BX571965
EMBL-CDS: CAH35257.1
RefSeq_NT: NC_006350.1
GenomeReviews: BX571965_GR
KEGG: bps:BPSL1263
HOGENOM: HBG751764
OMA: LTEMGCN
ProtClustDB: CLSK930570
BioCyc: BPSE272560:BPSL1263-MONOMER
Taxonomy ID 272560
Chromosome No 1
Gene Starting Position 1458135
Gene Ending Position 1459877
Gene Strand (Orientation) -
Protein Name hypothetical protein
DNA Sequence 
>gi|53717639:1458135-1459877 Burkholderia pseudomallei K96243 chromosome chromosome 1, complete sequence
GTCATGCGGTGGCGTGCAGATGGAGCTCCTGTGCCTCGAAGCGTTGCGCGAGTTCGTCGGACGGCAGCGC
CTGGCAGACGAGCCAGCCTTGAATGTGGTTGCAGCCCATCTCGGTGAGCAGCGTGCGCTGCGCCTCGGTC
TCGACGCCCTCCGCGACGAGCTCGAGCTCGAGCGTCTGCGCGAGGCCGACGACCGCCGACACGATCGCGC
GGTCGTTTCTGGACGTCAACAGATTTTCGACGAAACTGCGGTCGATCTTCAGCTTCGCGAGCGGGAAGCT
CTGCAGGTACGCGAGGCTCGAGTAGCCGGTGCCGAAATCGTCGACCGCGAACCGGATGCCGAGCTCGGTC
ACTTCCTCGAGCAGCGTCTTCGCATGATTCGGATCGTGCATCAGCAGGCTTTCGGTGATCTCGAGAACGA
TGCGGCGCGGATCGATGCCCGTCAGCTTGATCGCGTCGCGCACGCTCTGCGTGAAACGCGGATCGCGGAA
CTGCTGCGGCGACACGTTGACGGCCACGTACTGCAGCGCGATGCCTTGCCGGTCCCACGACACGAGCTGC
ATGCACGCGGCCTTCAGCACCCAGTTGCCGAGATAGTTGATGAGGCCGATCGATTCGGCGAGCGGGATGA
ACGTCGCGGGCGCGACGAGCCCGTGCACCGGATGGTGCCAGCGGATCAGCGCCTCGACGCCGACCACGGC
GCCCGACAGGCTCTTCGTGATCGGCTGGAAATGCAGCGAGAACTCGCCGTTGCGCACGCCGTTGTAGAGA
TCGGCCTCGAGCTTCAGGCGCTCGGCGTCGGCCGGATCGTCGGTCGGCTGGTGGAACGCGAGCGCGTTGC
CGCCCGCCGCCTTCGCCTGCGCGAGCGCGCGGTCCGCGCGCCGCAGCAGCGGGCTGTGGTGCTGCGCGTG
CTTCGACGTCGCGCGCGCGTCCGGATAGATCGCGATGCCGACGCTCGCCGACAGGTGCACGGCCTGCCCG
TCATACGCGTACGGCCGCTGGACGGCCGTCTGCAACTGGCGCGCGAGCGCTTCGGCCGCGTCGAGCGCGG
CGACGCGCGTGGGCGCGCTCAGCATCACCGCGAACTTGTCGCTCGCGACCCGCGCGAGCCGCTCGCCGCG
GGTCGCGAGCCGTTGCAGCCGCTGCGCGGTGTCGCGCAGCAGCGCGTCGCCCGCGTCGTAGCCGAGCGCG
CGGTTGATCCGCTGGTAATCGTCGAGATCGAGCAGCAGCAGCGCCGTGCAGCCGCCGCCTTCGTCGGCGA
TCTGCTGCGCGCGCATCAGCGCGGGCAGGAGCGCCGACAGGTTATCGAGCCCCGTCATCGGATCGTGGTG
CAGCTCGTAGGTGAGCCGGGCCTCGATCGCGCGCCACGACGACACGTCGAACGCGGCGATCGCGAAGCCG
TCGACGCCGTGGTGGCGGCTGCGCACCGCGCGCACCTCGACGTCGAGCGGATAGGTCAGCGATTTCACGA
GGCAGAGCGTCGCCTTCTCGACATCGCCCGTCTGCGACGCGCGCGCGAGCAGGCCGTCGAGCGTCGCGGT
ATCCTGCTCGGGGATCAGCTCGCGCAGCGTCAGCGTGTGCAGATAGTCGCGGTGATAACCGATGAAGCGC
AGGCTGGCATCGGACACGTACAGGAAGCGCAGGTCCCGGTCCACGTGGGCGAGGAAATCGACCGCGCCGA
CGGTTTGCTCCAGCCAGCTTCGAACTGTGTCGTCGGCGCGCGGCGTACCGGCGCGCGCGGGCA
Protein Sequence 
>gi|53718898|ref|YP_107884.1| hypothetical protein BPSL1263 [Burkholderia pseudomallei K96243] MPARAGTPRADDTVRSWLEQTVGAVDFLAHVDRDLRFLYVSDASLRFIGYHRDYLHTLTLRELIPEQDTATLDGLLARASQTGDVEKATLCLVKSLTYPLDVEVRAVRSRHHGVDGFAIAAFDVSSWRAIEARLTYELHHDPMTGLDNLSALLPALMRAQQIADEGGGCTALLLLDLDDYQRINRALGYDAGDALLRDTAQRLQRLATRGERLARVASDKFAVMLSAPTRVAALDAAEALARQLQTAVQRPYAYDGQAVHLSASVGIAIYPDARATSKHAQHHSPLLRRADRALAQAKAAGGNALAFHQPTDDPADAERLKLEADLYNGVRNGEFSLHFQPITKSLSGAVVGVEALIRWHHPVHGLVAPATFIPLAESIGLINYLGNWVLKAACMQLVSWDRQGIALQYVAVNVSPQQFRDPRFTQSVRDAIKLTGIDPRRIVLEITESLLMHDPNHAKTLLEEVTELGIRFAVDDFGTGYSSLAYLQSFPLAKLKIDRSFVENLLTSRNDRAIVSAVVGLAQTLELELVAEGVETEAQRTLLTEMGCNHIQGWLVCQALPSDELAQRFEAQELHLHATA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: BPSL1263 (cdpA) mutant has a 3-fold reduction in invasion of human lung epithelial cells and a 6-fold reduction in cytotoxicity on human macrophage cells (Lee et al., 2010).
COG COG2200T, under T: Signal transduction mechanisms
References
Lee et al., 2010: Lee HS, Gu F, Ching SM, Lam Y, Chua KL. CdpA is a Burkholderia pseudomallei cyclic di-GMP phosphodiesterase involved in autoaggregation, flagellum synthesis, motility, biofilm formation, cell invasion, and cytotoxicity. Infection and immunity. 2010; 78(5); 1832-1840. [PubMed: 20194589].