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pmlI

Victor ID 1990
Gene Name pmlI
Sequence Strain (Species/Organism) Burkholderia pseudomallei K96243
NCBI Gene ID 3097087
NCBI Protein GI 53721909
Locus Tag BPSS0885
Genbank Accession BX571966
Protein Accession YP_110894
Other Database IDs UniProtKB-ID: Q6UBQ0_BURPS
UniRef100: UniRef100_C4I2I1
UniRef90: UniRef90_C4I2I1
UniRef50: UniRef50_O30920
UniParc: UPI0000225B74
EMBL: AY373337
EMBL: EF688463
EMBL: BX571966
EMBL-CDS: AAQ90168.1
EMBL-CDS: ABU49182.1
EMBL-CDS: CAH38347.1
RefSeq_NT: NC_006351.1
GenomeReviews: BX571966_GR
KEGG: bps:BPSS0885
HOGENOM: HBG368426
OMA: GPGNAEW
ProtClustDB: CLSK897619
BioCyc: BPSE272560:BPSS0885-MONOMER
Taxonomy ID 272560
Chromosome No 2
Gene Starting Position 1177519
Gene Ending Position 1178130
Gene Strand (Orientation) -
Protein Name N-acylhomoserine lactone synthase
Protein pI 4.88
Protein Weight 20825.11
Protein Length 203
Protein Note Similar to Ralstonia solanacearum autoinducer synthesis protein SolI SWALL:SLI2_RALSO (SWALL:O30920) (204 aa) fasta scores: E(): 5.5e-51, 65.82% id in 199 aa, and to Burkholderia cepacia acyl homoserine lactone synthase CepI SWALL:Q9ZIU1 (EMBL: AF019654) (202 aa) fasta scores: E(): 6.6e-64, 76.84% id in 203 aa
DNA Sequence 
>gi|53721039:1177519-1178130 Burkholderia pseudomallei K96243 chromosome 2, complete sequence
CTCAGGCGGCTTCGGCGGGCGGCGCGCACAGCAGCGGGTCGAGATCGAGCGCGGCGAGCGTTTGCGCGTC
GAGGTCGATCCAGCACGCGACGACCATGCGCCCGTCGATCTGCTGCGCGGGCCCCGCCCGGTGCGCGTGC
ACGCCGATCCGGCGGAACAGGCGCTCCATGCTCAGAAACGTCACGCCGATCAGTTGCTTCGCGCCAAGCC
GCGCGGCGCACTCGACGACGGCGGCGAGCATCGGCCGCACCGCCCAGGCCGGGTTGCCGCCCCCGGCCGG
ATCCTCGGCGTTCGCGGCGAAGCGCGACAATTCCCAGACGGCGGCGGATTGCGGCAACGGCATGTCTTGC
GCGACCAGCGTCGGGAACAGTTCCTTCAGCAGATACGGGCGGGTCGTCGGCAGCAGCCGGGCGCAGCCGC
AGATTTCCCCGTCGTCGTCGCGGGCGAACACATAGACGGTATCGTCGCGATCGTACTGATCCCGCTCGAA
CCCTTCGCTTGCCGACGGCAGTTTCCAGCCGAGCTGCTCGACGAAAACTCGGTGCCGATAAAGGCCCAGA
TCAGCCGCCAAGTCGCTCGGCAGGCGCCCGTCGCCATGAACGAAAGTTCGCA
Protein Sequence 
>gi|53721909|ref|YP_110894.1| N-acylhomoserine lactone synthase [Burkholderia pseudomallei K96243]
MRTFVHGDGRLPSDLAADLGLYRHRVFVEQLGWKLPSASEGFERDQYDRDDTVYVFARDDDGEICGCARL
LPTTRPYLLKELFPTLVAQDMPLPQSAAVWELSRFAANAEDPAGGGNPAWAVRPMLAAVVECAARLGAKQ
LIGVTFLSMERLFRRIGVHAHRAGPAQQIDGRMVVACWIDLDAQTLAALDLDPLLCAPPAEAA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pmll mutant is attenuated in mice (Valade et al., 2004).
COG COG3916TQ, under T: Signal transduction mechanisms; Q: Secondary metabolites biosynthesis, transport and catabolism
References
Valade et al., 2004: Valade E, Thibault FM, Gauthier YP, Palencia M, Popoff MY, Vidal DR. The PmlI-PmlR quorum-sensing system in Burkholderia pseudomallei plays a key role in virulence and modulates production of the MprA protease. Journal of bacteriology. 2004; 186(8); 2288-2294. [PubMed: 15060030].