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leuB

Victor ID 1980
Gene Name leuB
Sequence Strain (Species/Organism) Burkholderia pseudomallei K96243
NCBI Gene ID 3094947
NCBI Protein GI 53722725
Locus Tag BPSS1705
Genbank Accession BX571966
Protein Accession YP_111710
Other Database IDs UniProtKB-ID: LEU3_BURPS
UniRef100: UniRef100_Q3JKG9
UniRef90: UniRef90_Q3JKG9
UniRef50: UniRef50_Q2J3B4
UniParc: UPI000043BDC7
EMBL: BX571966
EMBL-CDS: CAH39178.1
RefSeq_NT: NC_006351.1
GenomeReviews: BX571966_GR
KEGG: bps:BPSS1705
HOGENOM: HBG518924
OMA: NTMIYSE
ProtClustDB: PRK00772
BioCyc: BPSE272560:BPSS1705-MONOMER
Taxonomy ID 272560
Chromosome No 2
Gene Starting Position 2340375
Gene Ending Position 2341442
Gene Strand (Orientation) -
Protein Name 3-isopropylmalate dehydrogenase
Protein pI 5.02
Protein Weight 35706.02
Protein Length 355
Protein Note catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
DNA Sequence 
>gi|53721039:2340375-2341442 Burkholderia pseudomallei K96243 chromosome 2, complete sequence
CTTACAGCGCCGCGACCACCGCATCGCCCATCGCGGCCGTGCCCACCTGCTTGCAGCCCGGCGTCGCGAT
GTCGCCCGTGCGGTAGCCCTGCTCGAGCACCGCCTTGACCGCGCGCTCGATGCGGTCGGCCTGCTCCGCG
CGGTTCAGCGAGTAGCGCAGCAGCATCGCGGCCGACAGGATCGTCGCGAGCGGATTCGCGATGCCCTTGC
CCGCGATGTCCGGCGCGGAGCCGTGCGACGGCTCGTACAGGCCCTTGTTGCGCTGGTCGAGCGACGCGGA
CGGCAGCATGCCGATCGAGCCCGTCAGCATCGACGCCTCGTCGGACAAAATGTCGCCGAACATGTTGCCC
GTCACGATCACGTCGAACTGCTTCGGCGCCTTCGCGAGCTGCATCGCCGCGTTGTCGACGTACATGTGCG
ACAGCTCGACGTCCGCGTATTCCTTCGACACGTCGATCATCACGTCGCGCCAGAACTGCGACGTCTCGAG
CACGTTCGATTTGTCGACCGACAGCAGCTTCTTCGCGCGCTTTCGCGCGGCCTGGAACGCGACGTGCGCG
ATGCGGCGCACTTCCGGCTCCGAATAGCGCATCGTGTCGAAGCCTTCGCGCGCGCCCGCGAACGGGCCGT
CCGGCGCGGCGCGCACGCCGCGCGGCTGGCCGAAGTAGATATCGCCGTTCAGTTCGCGCACGATCAGGAT
GTCGAGGCCCGCGACGAGCTCGGGCTTGAGCGGCGAAGCGTCGACGAGTTGCGGATAGCAGATCGCCGGA
CGGAAGTTCGCGAACAGCTCCAGATGCTTGCGCAGGCCGAGGATCGCCTGCTCGGGGCGCAGCGCGCGCT
CGAGCGAATCGTACTTCCAGTCGCCGACCGCGCCGAACAGGATCGCGTCCGCTTCCTTCGCGAGCGCGAG
CGTCGCGTCGGGCAACGGATGGCCGCTTGCCTCGTAGCCGGCGCCGCCGACCGGCGCCTGCTCCAGTTCG
AACTTTTCGTCGAGCGCGTTCAGCACCTTCACCGCTTCATTGACGATTTCCGGACCGATGCCGTCGCCGG
GCAGCACTGCAATCTTCA
Protein Sequence 
>gi|53722725|ref|YP_111710.1| 3-isopropylmalate dehydrogenase [Burkholderia pseudomallei K96243]
MKIAVLPGDGIGPEIVNEAVKVLNALDEKFELEQAPVGGAGYEASGHPLPDATLALAKEADAILFGAVGD
WKYDSLERALRPEQAILGLRKHLELFANFRPAICYPQLVDASPLKPELVAGLDILIVRELNGDIYFGQPR
GVRAAPDGPFAGAREGFDTMRYSEPEVRRIAHVAFQAARKRAKKLLSVDKSNVLETSQFWRDVMIDVSKE
YADVELSHMYVDNAAMQLAKAPKQFDVIVTGNMFGDILSDEASMLTGSIGMLPSASLDQRNKGLYEPSHG
SAPDIAGKGIANPLATILSAAMLLRYSLNRAEQADRIERAVKAVLEQGYRTGDIATPGCKQVGTAAMGDA
VVAAL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: leuB mutant is attenuated in mice (Cuccui et al., 2007).
COG COG0473CE, under C: Energy production and conversion; E: Amino acid transport and metabolism
References
Cuccui et al., 2007: Cuccui J, Easton A, Chu KK, Bancroft GJ, Oyston PC, Titball RW, Wren BW. Development of signature-tagged mutagenesis in Burkholderia pseudomallei to identify genes important in survival and pathogenesis. Infection and immunity. 2007; 75(3); 1186-1195. [PubMed: 17189432].