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cpe

Victor ID 1923
Gene Name cpe
Sequence Strain (Species/Organism) Clostridium perfringens SM101
NCBI Gene ID 4204801
NCBI Protein GI 110801889
Locus Tag CPR_0381
Genbank Accession CP000312
Protein Accession YP_697710
Other Database IDs UniProtKB-ID: Q0SVZ0_CLOPS
UniRef100: UniRef100_P01558
UniRef90: UniRef90_P01558
UniRef50: UniRef50_P01558
UniParc: UPI00000BEF35
EMBL: CP000312
EMBL-CDS: ABG85760.1
RefSeq_NT: NC_008262.1
GenomeReviews: CP000312_GR
KEGG: cpr:CPR_0381
TIGR: CPR_0381
ProtClustDB: CLSK971752
BioCyc: CPER289380:CPR_0381-MONOMER
Taxonomy ID 289380
Gene Starting Position 464980
Gene Ending Position 465939
Gene Strand (Orientation) -
Protein Name enterotoxin Cpe
Protein pI 4.6
Protein Weight 33345.3
Protein Length 319
Protein Note identified by similarity to GB:CAA50691.1; match to protein family HMM PF03505
DNA Sequence 
>gi|110801439:464980-465939 Clostridium perfringens SM101 chromosome, complete genome
ATTAAAATTTTTGAAATAATATTGAATAAGGGTAATTTCCACTATATGATGAATTAGCTTTCATTACAAG
AACATATTGTCCAGCATCTAAGCTTATATCAACATAATGATCTTTTACTCCATCACCTAAGGACTGTTCT
AATTTCACTAGATTATTAAAATTATTTGAATAAATATTAAAATCAACAATTTTGCTAGCTAAGATTCTAT
ATTTTTGTCCAGTAGCTGTAATTGTTAAGTGTAAATTAAGCTTTTGAGTCCAAGGGTATGAGTTAGAAGA
ACGCCAATCATATAAATTACCAGCTGGATTTGAGTTTAATGCATCAGTTAAATTTAATCTTTCTGTAGCA
GCAGCTAAATCAAGGATTTCTTTTTCTATATCTGTAGATGGAACTGTTAAAACACATCTTTCACCAGTTT
CAATTAATGAACCTTGATCAATATTTCCTAAGCTATCTGCAGATGTTTTACTAAGCCATATTCCTGTTAA
TTTATAAATTGATCCATCATCAGAGATATTACCATGAGAAATTCTAATAGCTTGATACTTTCTATAAGTT
GCATAAACCTTATAATATACATATTCATTTGGACCAGCAGTTGTAGATACAGATCTTTCTATTGTATTTT
GTTCTCCTATAGTTATTCCAAATCCATATTCTACAGATGCTTGTATAAATTCAGAAGTAAATCCAACTGA
AAAATTTACATTTATAGATACTTCTTTAGATTTAGTTAATGATTGGCTAAAGGTACCTGTTTCATTAGGA
TTAAGAATTTGACTTGAAACTACTGAGGGTTCCCCTAATATCCAACCATCTCCTTTATCTATTACATATA
ATCCATCACTTAAATTTGAGTTAGAGTTTGTAATATTAATTGGTGTTTTTAAATCCTCAGAAATAAGAAA
TACTTCTTTAGCATTTTCGAACACCATTGGATTTAAATTGTTACTAAGCA
Protein Sequence 
>gi|110801889|ref|YP_697710.1| enterotoxin Cpe [Clostridium perfringens SM101]
MLSNNLNPMVFENAKEVFLISEDLKTPINITNSNSNLSDGLYVIDKGDGWILGEPSVVSSQILNPNETGT
FSQSLTKSKEVSINVNFSVGFTSEFIQASVEYGFGITIGEQNTIERSVSTTAGPNEYVYYKVYATYRKYQ
AIRISHGNISDDGSIYKLTGIWLSKTSADSLGNIDQGSLIETGERCVLTVPSTDIEKEILDLAAATERLN
LTDALNSNPAGNLYDWRSSNSYPWTQKLNLHLTITATGQKYRILASKIVDFNIYSNNFNNLVKLEQSLGD
GVKDHYVDISLDAGQYVLVMKANSSYSGNYPYSILFQKF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: cpe knockout mutant is avirulent in rabbit ileal loop model (Sarker et al., 1999).
References
Sarker et al., 1999: Sarker MR, Carman RJ, McClane BA. Inactivation of the gene (cpe) encoding Clostridium perfringens enterotoxin eliminates the ability of two cpe-positive C. perfringens type A human gastrointestinal disease isolates to affect rabbit ileal loops. Molecular microbiology. 1999; 33(5); 946-958. [PubMed: 10476029].