Victors

L
Victor ID	1914
Gene Name	L
Sequence Strain (Species/Organism)	Measles virus
NCBI Gene ID	1489802
NCBI Protein GI	9626952
Locus Tag	MeVgp6
Protein Accession	NP_056924.1
Other Database IDs	UniProtKB-ID: Q784S0_9PARA UniRef100: UniRef100_Q9WMB3 UniRef90: UniRef90_P35975 UniRef50: UniRef50_P12576 UniParc: UPI00000F53F7 EMBL: AB032167 EMBL-CDS: BAA84132.1 RefSeq_NT: NC_001498.1
Taxonomy ID	11234
Gene Starting Position	9233
Gene Ending Position	15784
Gene Strand (Orientation)	+
Protein Name	large polymerase
DNA Sequence	>gi\|9626945:9233-15784 Measles virus, complete genome TATGGACTCGCTATCTGTCAACCAGATCTTATACCCTGAAGTTCACCTAGATAGCCCGATAGTTACCAAT AAGATAGTAGCTATCCTGGAGTATGCTCGAGTCCCTCACGCTTACAGCCTGGAGGACCCTACACTGTGTC AGAACATCAAGCACCGCCTAAAAAACGGATTCTCCAACCAAATGATTATAAACAATGTGGAAGTTGGGAA TGTCATCAAGTCCAAGCTTAGGAGTTATCCGGCCCACTCTCATATTCCATATCCAAATTGTAATCAGGAT TTATTTAACATAGAAGACAAAGAGTCAACAAGGAAGATCCGTGAGCTCCTAAAAAAGGGAAATTCGCTGT ACTCCAAAGTCAGTGATAAGGTTTTCCAATGCCTGAGGGACACTAACTCACGGCTTGGCCTAGGCTCCGA ATTGAGGGAGGACATCAAGGAGAAAATTATTAACTTGGGAGTTTACATGCACAGCTCCCAATGGTTTGAG CCCTTTCTGTTTTGGTTTACAGTCAAGACTGAGATGAGGTCAGTGATTAAATCACAAACCCATACTTGCC ATAGGAGGAGACACACACCTGTATTCTTCACTGGTAGTTCAGTTGAGCTGTTAATCTCTCGTGACCTTGT TGCTATAATCAGTAAGGAGTCTCAACATGTATATTACCTGACGTTTGAACTGGTTTTGATGTATTGTGAT GTCATAGAGGGGAGGTTAATGACAGAGACCGCTATGACCATTGATGCTAGGTATGCAGAACTTCTAGGAA GAGTCAGATACATGTGGAAACTGATAGATGGTTTCTTCCCTGCACTCGGGAATCCAACTTATCAAATTGT AGCCATGCTGGAGCCACTTTCACTTGCTTACCTGCAACTGAGGGATATAACAGTAGAACTCAGAGGTGCT TTCCTTAACCACTGCTTTACTGAAATACATGATGTTCTTGACCAAAACGGGTTTTCTGATGAAGGTACTT ATCATGAGTTAATTGAAGCCCTAGATTACATTTTCATAACTGATGACATACATCTGACAGGGGAGATTTT CTCATTTTTCAGAAGTTTCGGCCACCCCAGACTTGAAGCAGTAACGGCTGCTGAAAATGTCAGGAAATAC ATGAATCAGCCTAAAGTCATTGTGTATGAGACTCTGATGAAAGGTCATGCCATATTTTGTGGAATCATAA TCAACGGCTATCGTGACAGGCACGGAGGCAGTTGGCCACCCCTGACCCTCCCCCTGCATGCTGCAGACAC AATCCGGAATGCTCAAGCTTCAGGTGAAGGGTTAACACATGAGCAGTGCGTTGATAACTGGAAATCATTT GCTGGAGTGAGATTTGGCTGTTTTATGCCTCTTAGCCTGGACAGTGATCTGACAATGTACCTAAAGGACA AGGCACTTGCTGCTCTCCAAAGGGAATGGGATTCAGTTTACCCGAAAGAGTTCCTGCGTTACGATCCTCC CAAGGGAACCGGGTCACGGAGGCTTGTAGATGTTTTCCTTAATGATTCGAGCTTTGACCCATATGATATG ATAATGTATGTCGTAAGTGGAGCCTACCTCCATGACCCTGAGTTCAACCTGTCTTACAGCCTGAAAGAAA AGGAGATCAAGGAAACAGGTAGACTTTTCGCTAAAATGACTTACAAAATGAGGGCATGCCAAGTGATCGC TGAAAATCTAATCTCAAACGGGATTGGCAAGTATTTTAAGGACAATGGGATGGCCAAGGATGAGCACGAT TTGACTAAGGCACTCCACACTCTGGCTGTCTCAGGAGTCCCCAAAGATCTCAAAGAAAGTCACAGGGGGG GGCCAGTCTTAAAAACCTACTCCCGAAGCCCAGTCCACACAAGTACCAGGAACGTTAAAGCAGAAAAAGG GTTTGTAGGATTCCCTCATGTAATTCGGCAGAATCAAGACACTGATCATCCGGAGAATATAGAAACCTAC GAGACAGTCAGCGCATTTATCACGACTGATCTCAAGAAGTACTGCCTTAATTGGAGATATGAGACCATCA GCTTATTTGCACAGAGGCTAAATGAGATTTACGGATTACCCTCATTTTTTCAGTGGCTGCATAAGAGGCT TGAAACCTCTGTCCTCTATGTAAGTGACCCTCATTGCCCCCCCGACCTTGACGCCCATGTCCCGTTATGC AAAGTCCCCAATGACCAAATCTTCATCAAGTACCCTATGGGAGGTATAGAAGGGTATTGTCAGAAGCTGT GGACCATCAGCACCATTCCCTACTTATACCTGGCTGCTTATGAGAGCGGGGTAAGGATTGCTTCGTTAGT GCAAGGGGACAATCAGACCATAGCCGTAACAAAAAGGGTACCCAGCACATGGCCTTACAACCTTAAGAAA CGGGAAGCTGCTAGAGTAACTAGAGATTACTTTGTAATTCTTAGGCAAAGGCTACATGACATTGGCCATC ACCTCAAGGCAAATGAGACAATTGTTTCATCACATTTTTTTGTCTATTCAAAAGGAATATATTATGATGG GCTACTTGTGTCCCAATCACTCAAGAGCATCGCAAGATGTGTATTCTGGTCAGAGACTATAGTTGATGAA ACAAGGGCAGCATGCAGTAATATTGCTACAACAATGGCTAAAAGCATCGAGAGAGGTTATGACCGTTATC TTGCATATTCCCTGAACGTCCTAAAAGTGATACAGCAAATTTTGATCTCTCTTGGCTTCACAATCAATTC AACCATGACCCGAGATGTAGTCATACCCCTCCTCACAAACAACGATCTCTTAATAAGGATGGCACTGTTG CCCGCTCCTATTGGGGGGATGAATTATCTGAATATGAGCAGGCTGTTTGTCAGAAACATCGGTGATCCAG TAACATCATCAATTGCTGATCTCAAGAGAATGATTCTCGCATCACTAATGCCTGAAGAGACCCTCCATCA AGTAATGACACAACAACCGGGGGACTCTTCATTCCTAGACTGGGCTAGCGACCCTTACTCAGCAAATCTT GTATGCGTCCAGAGCATCACTAGACTCCTCAAGAACATAACTGCAAGGTTTGTCCTAATCCATAGTCCAA ACCCAATGTTAAAAGGGTTATTCCATGATGACAGTAAAGAAGAGGACGAGAGACTGGCGGCATTCCTCAT GGACAGGCATATTATAGTACCTAGGGCAGCTCATGAAATCCTGGATCATAGTGTCACAGGGGCAAGAGAG TCTATTGCAGGCATGCTAGATACCACAAAAGGCCTGATTCGAGCCAGCATGAGGAAGGGGGGGTTAACCT CTCGAGTGATAACCAGATTGTCCAATTATGACTATGAACAATTTAGAGCAGGGATGGTGCTATTGACAGG AAGAAAGAGAAATGTCCTCATTGACAAAGAGTCATGTTCAGTGCAGCTGGCTAGAGCCCTAAGAAGCCAT ATGTGGGCAAGACTAGCTCGAGGACGGCCTATTTACGGCCTTGAGGTCCCTGATGTACTAGAATCTATGC GAGGCCACCTTATTCGGCGTCATGAGACATGTGTCATCTGCGAGTGTGGATCAGTCAACTACGGATGGTT TTTTGTCCCCTCGGGTTGCCAACTGGATGATATTGACAAGGAAACATCATCCTTGAGAGTCCCATATATT GGTTCTACCACTGATGAGAGAACAGACATGAAGCTCGCCTTCGTAAGAGCCCCAAGTAGATCCTTGCGAT CTGCCGTTAGAATAGCAACAGTGTACTCATGGGCTTACGGTGATGATGATAGCTCTTGGAACGAAGCCTG GTTGTTGGCAAGGCAAAGGGCCAATGTGAGCCTGGAGGAGCTAAGGGTGATCACTCCCATCTCGACTTCG ACTAATTTAGCGCATAGGTTGAGGGATCGTAGCACTCAAGTGAAATACTCAGGTACATCCCTTGTCCGAG TGGCAAGGTATACCACAATCTCCAACGACAATCTCTCATTTGTCATATCAGATAAGAAGGTTGATACTAA CTTTATATACCAACAAGGAATGCTTCTAGGGTTGGGTGTTTTAGAAACATTGTTTCGACTCGAGAAAGAT ACTGGATCATCTAACACGGTATTACATCTTCACGTCGAAACAGATTGTTGCGTGATCCCGATGATAGATC ATCCCAGGATACCCAGCTCCCGCAAGCTAGAGCTGAGGGCAGAGCTATGTACCAACCCATTGATATATGA TAATGCACCTTTAATTGACAGAGATGCAACAAGGCTATACACCCAGAGCCATAGGAGGCACCTTGTGGAA TTTGTTACATGGTCCACACCCCAACTATATCACATTCTAGCTAAGTCCACAGCACTATCTATGATTGACC TGGTAACAAAATTTGAGAAGGACCATATGAATGAAATTTCAGCTCTCATAGGGGATGACGATATCAATAG TTTCATAACTGAGTTTCTGCTTATAGAGCCAAGATTATTCACCATCTACTTGGGCCAGTGTGCAGCCATC AATTGGGCATTTGATGTACATTATCATAGACCATCAGGGAAATATCAGATGGGTGAGCTGTTGTCTTCGT TCCTTTCTAGAATGAGCAAAGGAGTGTTTAAGGTGCTTGTCAATGCTCTAAGCCACCCAAAGATCTACAA GAAATTCTGGCATTGTGGTATTATAGAGCCTATCCATGGTCCTTCACTTGATGCTCAAAACTTGCACACA ACTGTGTGCAACATGGTTTACACATGCTATATGACCTACCTCGACCTGTTGTTGAATGAAGAGTTAGAAG AGTTCACATTTCTTTTGTGTGAAAGCGATGAGGATGTAGTACCGGACAGATTCGACAACATCCAGGCAAA ACACTTGTGTGTTCTGGCAGATTTGTACTGTCAACCAGGGACCTGCCCACCGATTCGAGGTCTAAGGCCG GTAGAGAAATGTGCAGTTCTAACCGATCATATCAAGGCAGAGGCTAGGTTATCTCCAGCAGGATCTTCGT GGAACATAAATCCAATTATTGTAGACCATTACTCATGCTCTCTGACTTATCTCCGTCGAGGATCTATCAA ACAGATAAGATTGAGAGTTGATCCAGGATTCATTTTTGACGCCCTCGCTGAGGTAAATGTCAGTCAGCCA AAGGTCGGCAGCAACAACATCTCAAATATGAGCATCAAGGATTTCAGACCTCCACACGATGATGTTGCAA AATTGCTCAAAGATATCAACACAAGCAAGCACAATCTTCCCATTTCAGGGGGTAGTCTCGCCAATTATGA AATCCATGCTTTCCGCAGAATCGGGTTAAACTCATCTGCTTGCTACAAAGCTGTTGAGATATCAACATTA ATTAGGAGATGCCTTGAGCCAGGGGAAGACGGCTTGTTCTTGGGTGAGGGGTCGGGTTCTATGTTGATCA CTTATAAGGAGATACTAAAACTAAACAAGTGCTTCTATAATAGTGGGGTTTCCGCCAATTCTAGATCTGG TCAAAGGGAATTAGCACCCTATCCCTCCGAAGTTGGCCTTGTCGAACACAGAATGGGAGTAGGTAATATT GTCAAGGTGCTCTTTAACGGGAGGCCCGAAGTCACGTGGGTAGGCAGTATAGATTGCTTCAATTTCATAG TCAGTAATATCCCTACCTCTAGTGTGGGGTTTATCCATTCAGATATAGAGACCTTACCTAACAAAGATAC TATAGAGAAGCTAGAGGAATTGGCAGCCATCTTATCGATGGCTCTACTCCTTGGCAAAATAGGATCAATA CTGGTGATTAAGCTTATGCCTTTCAGCGGGGATTTTGTTCAGGGATTTATAAGCTATGTAGGGTCTCATT ATAGAGAAGTGAACCTTGTCTACCCTAGGTACAGCAACTTCATATCTACTGAATCTTATTTAGTTATGAC AGATCTCAAAGCTAACCGGCTAATGAATCCTGAAAAGATCAAGCAGCAGATAATTGAATCATCTGTGCGG ACTTCACCTGGACTTATAGGTCACATCCTATCCATTAAGCAACTAAGCTGCATACAAGCAATTGTGGGAG GCGCAGTTAGTAGAGGTGATATCAACCCTATTCTGAAAAAACTTACACCTATAGAGCAGGTGCTGATCAG TTGCGGGTTGGCAATTAACGGACCTAAACTGTGCAAAGAATTAATCCACCATGATGTTGCCTCAGGGCAA GATGGATTGCTTAACTCTATACTCATCCTCTACAGGGAGTTGGCAAGATTCAAAGACAACCAAAGAAGTC AACAAGGGATGTTCCACGCTTACCCCGTATTGGTAAGTAGTAGGCAACGAGAACTTGTATCTAGGATCAC TCGCAAATTTTGGGGGCATATTCTTCTTTACTCCGGGAACAGAAAGTTGATAAATCGGTTTATCCAGAAT CTCAAGTCCGGTTATCTAGTACTAGACTTACACCAGAATATCTTCGTTAAGAATCTATCCAAGTCAGAGA AACAGATTATTATGACGGGGGGTTTAAAACGTGAGTGGGTTTTTAAGGTAACAGTCAAGGAGACCAAAGA ATGGTACAAGTTAGTCGGATACAGCGCTCTGATTAAGGATTA
Protein Sequence	>gi\|9626952\|ref\|NP_056924.1\| large polymerase protein [Measles virus] MDSLSVNQILYPEVHLDSPIVTNKIVAILEYARVPHAYSLEDPTLCQNIKHRLKNGFSNQMIINNVEVGNVIKSKLRSYPAHSHIPYPNCNQDLFNIEDKESTRKIRELLKKGNSLYSKVSDKVFQCLRDTNSRLGLGSELREDIKEKIINLGVYMHSSQWFEPFLFWFTVKTEMRSVIKSQTHTCHRRRHTPVFFTGSSVELLISRDLVAIISKESQHVYYLTFELVLMYCDVIEGRLMTETAMTIDARYAELLGRVRYMWKLIDGFFPALGNPTYQIVAMLEPLSLAYLQLRDITVELRGAFLNHCFTEIHDVLDQNGFSDEGTYHELIEALDYIFITDDIHLTGEIFSFFRSFGHPRLEAVTAAENVRKYMNQPKVIVYETLMKGHAIFCGIIINGYRDRHGGSWPPLTLPLHAADTIRNAQASGEGLTHEQCVDNWKSFAGVRFGCFMPLSLDSDLTMYLKDKALAALQREWDSVYPKEFLRYDPPKGTGSRRLVDVFLNDSSFDPYDMIMYVVSGAYLHDPEFNLSYSLKEKEIKETGRLFAKMTYKMRACQVIAENLISNGIGKYFKDNGMAKDEHDLTKALHTLAVSGVPKDLKESHRGGPVLKTYSRSPVHTSTRNVKAEKGFVGFPHVIRQNQDTDHPENIETYETVSAFITTDLKKYCLNWRYETISLFAQRLNEIYGLPSFFQWLHKRLETSVLYVSDPHCPPDLDAHVPLCKVPNDQIFIKYPMGGIEGYCQKLWTISTIPYLYLAAYESGVRIASLVQGDNQTIAVTKRVPSTWPYNLKKREAARVTRDYFVILRQRLHDIGHHLKANETIVSSHFFVYSKGIYYDGLLVSQSLKSIARCVFWSETIVDETRAACSNIATTMAKSIERGYDRYLAYSLNVLKVIQQILISLGFTINSTMTRDVVIPLLTNNDLLIRMALLPAPIGGMNYLNMSRLFVRNIGDPVTSSIADLKRMILASLMPEETLHQVMTQQPGDSSFLDWASDPYSANLVCVQSITRLLKNITARFVLIHSPNPMLKGLFHDDSKEEDERLAAFLMDRHIIVPRAAHEILDHSVTGARESIAGMLDTTKGLIRASMRKGGLTSRVITRLSNYDYEQFRAGMVLLTGRKRNVLIDKESCSVQLARALRSHMWARLARGRPIYGLEVPDVLESMRGHLIRRHETCVICECGSVNYGWFFVPSGCQLDDIDKETSSLRVPYIGSTTDERTDMKLAFVRAPSRSLRSAVRIATVYSWAYGDDDSSWNEAWLLARQRANVSLEELRVITPISTSTNLAHRLRDRSTQVKYSGTSLVRVARYTTISNDNLSFVISDKKVDTNFIYQQGMLLGLGVLETLFRLEKDTGSSNTVLHLHVETDCCVIPMIDHPRIPSSRKLELRAELCTNPLIYDNAPLIDRDATRLYTQSHRRHLVEFVTWSTPQLYHILAKSTALSMIDLVTKFEKDHMNEISALIGDDDINSFITEFLLIEPRLFTIYLGQCAAINWAFDVHYHRPSGKYQMGELLSSFLSRMSKGVFKVLVNALSHPKIYKKFWHCGIIEPIHGPSLDAQNLHTTVCNMVYTCYMTYLDLLLNEELEEFTFLLCESDEDVVPDRFDNIQAKHLCVLADLYCQPGTCPPIRGLRPVEKCAVLTDHIKAEARLSPAGSSWNINPIIVDHYSCSLTYLRRGSIKQIRLRVDPGFIFDALAEVNVSQPKVGSNNISNMSIKDFRPPHDDVAKLLKDINTSKHNLPISGGSLANYEIHAFRRIGLNSSACYKAVEISTLIRRCLEPGEDGLFLGEGSGSMLITYKEILKLNKCFYNSGVSANSRSGQRELAPYPSEVGLVEHRMGVGNIVKVLFNGRPEVTWVGSIDCFNFIVSNIPTSSVGFIHSDIETLPNKDTIEKLEELAAILSMALLLGKIGSILVIKLMPFSGDFVQGFISYVGSHYREVNLVYPRYSNFISTESYLVMTDLKANRLMNPEKIKQQIIESSVRTSPGLIGHILSIKQLSCIQAIVGGAVSRGDINPILKKLTPIEQVLISCGLAINGPKLCKELIHHDVASGQDGLLNSILILYRELARFKDNQRSQQGMFHAYPVLVSSRQRELVSRITRKFWGHILLYSGNRKLINRFIQNLKSGYLVLDLHQNIFVKNLSKSEKQIIMTGGLKREWVFKVTVKETKEWYKLVGYSALIKD
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: The L gene from the attenuated Edmonston strain replaced the L protein of a virulent clinical isolate IC-B of the measles virus and grown in Vero cells. The recombinant viruses had had growth disadvantage in CD150-positive lymphoid B95a cells compared to the wild type IC-B (Tahara et al., 2005).
References	*Tahara et al., 2005:* Tahara M, Takeda M, Yanagi Y. Contributions of matrix and large protein genes of the measles virus edmonston strain to growth in cultured cells as revealed by recombinant viruses. Journal of virology. 2005; 79(24); 15218-15225. [PubMed: 16306593].


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