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A46R

Victor ID 1913
Gene Name A46R
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707702
NCBI Protein GI 66275969
Locus Tag VACWR172
Protein Accession YP_233054.1
Other Database IDs UniProtKB-ID: VA46_VACCW
UniRef100: UniRef100_P26672
UniRef90: UniRef90_P26672
UniRef50: UniRef50_P33876
UniParc: UPI0000138071
EMBL: M72474
EMBL: D11079
EMBL-CDS: AAA48313.1
EMBL-CDS: BAA01820.1
RefSeq_NT: NC_006998.1
Taxonomy ID 10245
Gene Starting Position 153146
Gene Ending Position 153868
Gene Strand (Orientation) +
Protein Name Toll/IL1-receptor
DNA Sequence 
>gi|66275797:153146-153868 Vaccinia virus, complete genome
AATGGCGTTTGATATATCAGTTAATGCGTCTAAAACAATAAATGCATTAGTTTACTTTTCTACTCAGCAA
AATAAATTAGTCATACGTAATGAAGTTAATGATACACACTACACTGTCGAATTTGATAGGGACAAAGTAG
TTGACACGTTTATTTCATATAATAGACATAATGACACCATAGAGATAAGAGGGGTGCTTCCAGAGGAAAC
TAATATTGGTTGCGCGGTTAATACGCCGGTTAGTATGACTTACTTGTATAATAAGTATAGTTTTAAACTG
ATTTTAGCAGAATATATAAGACACAGAAATACTATATCCGGCAATATTTATTCGGCATTGATGACACTAG
ATGATTTGGCTATTAAACAGTATGGAGACATTGATCTATTATTTAATGAGAAACTTAAAGTAGACTCCGA
TTCGGGACTATTTGACTTTGTCAACTTTGTAAAGGATATGATATGTTGTGATTCTAGAATAGTAGTAGCT
CTATCTAGTCTAGTATCTAAACATTGGGAATTGACAAATAAAAAGTATAGGTGTATGGCATTAGCCGAAC
ATATATCTGATAGTATTCCAATATCTGAGCTATCTAGACTACGATACAATCTATGTAAGTATCTACGCGG
ACACACTGAGAGCATAGAGGATAAATTTGATTATTTTGAAGACGATGATTCGTCTACATGTTCTGCCGTA
ACCGACAGGGAAACGGATGTATA
Protein Sequence 
>gi|66275969|ref|YP_233054.1| Toll/IL1-receptor [Vaccinia virus] MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALAEHISDSIPISELSRLRYNLCKYLRGHTESIEDKFDYFEDDDSSTCSAVTDRETDV
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: Vaccinia virus lacking the A46R gene was attenuated in a murine intranasal model (Stack et al., 2005).
References
Stack et al., 2005: Stack J, Haga IR, Schröder M, Bartlett NW, Maloney G, Reading PC, Fitzgerald KA, Smith GL, Bowie AG. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. The Journal of experimental medicine. 2005; 201(6); 1007-1018. [PubMed: 15767367].