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C12L

Victor ID 1909
Gene Name C12L
Sequence Strain (Species/Organism) Vaccinia virus
NCBI Gene ID 3707582
NCBI Protein GI 66276002
Locus Tag VACWR205
Protein Accession YP_233087.1
Other Database IDs UniProtKB-ID: SPI1_VACCW
UniRef100: UniRef100_P15058
UniRef90: UniRef90_P33829
UniRef50: UniRef50_P33829
UniParc: UPI0000135E24
EMBL: D11079
EMBL: M24217
EMBL: D00582
EMBL: M23701
EMBL: AY243312
EMBL-CDS: BAA01852.1
EMBL-CDS: AAA48344.1
EMBL-CDS: BAA00459.1
EMBL-CDS: AAA69589.1
EMBL-CDS: AAO89484.1
RefSeq_NT: NC_006998.1
ProtClustDB: CLSP2509855
Taxonomy ID 10245
Gene Starting Position 182510
Gene Ending Position 183571
Gene Strand (Orientation) +
Protein Name temporal expression: early
DNA Sequence 
>gi|66275797:182510-183571 Vaccinia virus, complete genome
CATGGATATCTTTAAAGAACTAATCTTAAAACACACGGATGAAAATGTTTTGATTTCTCCAGTTTCTATT
TTATCTACTTTATCTATTCTAAATCATGGAGCAGCTGGTTCTACAGCTGAACAACTATCAAAATATATAG
AGAATATGAATGAGAATACACCCGATGACAATAATGACATGGACGTAGATATTCCGTATTGTGCGACACT
AGCTACCGCAAATAAAATATACGGTAGCGATAGTATCGAGTTCCACGCCTCCTTCCTACAAAAAATAAAA
GACGATTTTCAAACTGTAAACTTTAATAATGCTAACCAAACAAAGGAACTAATCAACGAATGGGTTAAGA
CAATGACAAATGGTAAAATTAATTCCTTATTGACTAGTCCGCTATCCATTAATACTCGTATGACAGTTGT
TAGCGCCGTCCATTTTAAAGCAATGTGGAAATATCCATTTTCTAAACATCTTACATATACAGACAAGTTT
TATATTTCTAAGAATATAGTTACCAGTGTTGATATGATGGTGAGCACTGAGAATAACTTGCAATATGTAC
ATATTAATGAATTATTCGGAGGATTCTCTATTATCGATATTCCATACGAGGGAAACTCTAGTATGGTAAT
TATACTACCGGACGACATAGAAGGTATATATAACATAGAAAAAAATATAACAGATGAAAAATTTAAAAAA
TGGTGTGGTATGTTATCTACTAAAAGTATAGACTTGTATATGCCAAAGTTTAAAGTGGAAATGACAGAAC
CGTATAATCTGGTACCGATTTTAGAAAATTTAGGACTTACTAATATATTCGGATATTATGCAGATTTTAG
CAAGATGTGTAATGAAACTATCACTGTAGAAAAATTTCTACATACGACGTTTATAGATGTTAATGAGGAG
TATACAGAAGCATCGGCCGTTACAGGAGTATTTATGACTAACTTTTCGATGGTATATCGTACGAAGGTCT
ACATAAACCATCCATTCATGTACATGATTAAAGACAACACAGGACGTATACTTTTTATAGGGAAATACTG
CTATCCGCAATA
Protein Sequence 
>gi|66276002|ref|YP_233087.1| serine protease inhibitor-like SPI-1 [Vaccinia virus] MDIFKELILKHTDENVLISPVSILSTLSILNHGAAGSTAEQLSKYIENMNENTPDDNNDMDVDIPYCATLATANKIYGSDSIEFHASFLQKIKDDFQTVNFNNANQTKELINEWVKTMTNGKINSLLTSPLSINTRMTVVSAVHFKAMWKYPFSKHLTYTDKFYISKNIVTSVDMMVSTENNLQYVHINELFGGFSIIDIPYEGNSSMVIILPDDIEGIYNIEKNITDEKFKKWCGMLSTKSIDLYMPKFKVEMTEPYNLVPILENLGLTNIFGYYADFSKMCNETITVEKFLHTTFIDVNEEYTEASAVTGVFMTNFSMVYRTKVYINHPFMYMIKDNTGRILFIGKYCYPQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: C12L mutant is attenuated in BALB/c mice when infected intranasally (Symons et al., 2002).
References
Symons et al., 2002: Symons JA, Adams E, Tscharke DC, Reading PC, Waldmann H, Smith GL. The vaccinia virus C12L protein inhibits mouse IL-18 and promotes virus virulence in the murine intranasal model. The Journal of general virology. 2002; 83(Pt 11); 2833-2844. [PubMed: 12388820].