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iucD from Shigella flexneri 5 str. 8401

Victor ID 1808
Gene Name iucD from Shigella flexneri 5 str. 8401
Sequence Strain (Species/Organism) Shigella flexneri 5 str. 8401
NCBI Gene ID 4210324
NCBI Protein GI 110807646
Locus Tag SFV_3851
Protein Accession YP_691166.1
Other Database IDs UniProtKB-ID: Q0SYK4_SHIF8
UniRef100: UniRef100_Q0SYK4
UniRef90: UniRef90_P11295
UniRef50: UniRef50_P11295
UniParc: UPI000000E790
EMBL: CP000266
EMBL-CDS: ABF05861.1
RefSeq_NT: NC_008258.1
EnsemblGenome: EBESCG00000095217.
EnsemblGenome_TRS: EBESCT00000096173
EnsemblGenome_PRO: EBESCP00000092369
GenomeReviews: CP000266_GR
KEGG: sfv:SFV_3851
eggNOG: COG3486
HOGENOM: HBG415390
OMA: SAVYPES
ProtClustDB: CLSK888708
BioCyc: SFLE373384:SFV_3851-MONOMER
Taxonomy ID 373384
Gene Starting Position 3950486
Gene Ending Position 3951823
Gene Strand (Orientation) -
Protein Name lysine:N6-hydroxylase
DNA Sequence 
>gi|110804074:3950486-3951823 Shigella flexneri 5 str. 8401, complete genome
GTTATTCCTGAATATTTGCTGTATAGTGAGTTAAAGAAGCAGCCTCCGGCTGTGGTTTTTTCCGGCTGCC
GCTGCGCCACTGAATCAGTGCGGGCGGCATACTGAGATCGAATAAATCACGCCCCAGTACGCGATTAAGA
ATACGTGCAGATCGCCAGGCCATCAGGCTGAGCTGGGGTTCGGCGATGCCATGAGTTTGCATGCTGGCGT
TGACCGCAAAGATGTTATTTTCTTTCGGGCCACTCCATTCCAGAGTGAAGTCATCACGCACTTTAAAGGT
GTTCTTATCGTGCATGGTGATCAAGGGCATCAGTGAGGGAAGTATTTGTGGCAATGCAGAACGGTAACCT
GTGGCGAAAATCACCACATCACTTTCCAGGCTCTCTCTGCCCTGATCCAGATGATGTTCCATCAATAACC
TCCAGCCCGGACCACTACTTTCCAGAGTTGTTACCGAGCGACTGGGTAGCAGACGGATATTTCTTGGTTT
TCTCAGAACTTCAAAACGGTGGTACAACTCACGATAAATGGTCAGTAAAGAATCGGCAGTGATGCCATCC
GATGTCATTTTCTGCTCATCCAGTAACTGATGGCGAATATCTTCCTTCAGTCCGGAGAAGCCTGAAATAT
ATTCAGGTGTAAAATACTCATCAGCAAAAGCAGCCTCATCCAGTGCGTTAAAATTATTACGCCGTGAGAC
CCAGTTTATTTCCGCCGCTTCTCCCCATTCCCCGCGTAATGCATTAAGGAACAGGTCTGCACCACTCTGT
CCTCCACCAACCACGGTTATCCGTTTTCCACTCAGGTCCGGCCGACGAAGATTCATTTCACTGGCATGGA
AACAGGATTGTGTCACATGCTTCACACAGGGTGGTAAATAAGGTTGTTTTCCTGTACCAAGGCAGATATT
GTGGGCAAAATATTCTCCCCGACTGGTCTGAACCAGAAACAATCGACTTTTTTTGTCGAAATCAATATTT
TCAACGGTATGACTGAAATACAGGTTATTCATATCTTCAGCAGCCCAGCGGAGATAGTCAGAAAACTCTT
CACGGGATACTGTACGTAGCCTGCTTGTAAGGAAGCGATAGAACTTTTTGTGCTTCACCAGATAGTTAAC
AAAGCTGTAGGGATTTGTAGGTGCAACTGCACTGACCAGATCTTTCAGAAAGACGGTCTGCATATGACAA
TCCGGTACCAGCATACCCGGATGCCAGGAAAAATGAGGATGTTCGTCAAAGAAGAGACAGTTCAGTTCTT
CGATCTGATGTGACAATGCAGCAATGCTGAGATTAAATGGCCCTGTCCCGACACCAATAAAATCGACACT
TTTTTTCA
Protein Sequence 
>gi|110807646|ref|YP_691166.1| lysine:N6-hydroxylase [Shigella flexneri 5 str. 8401] MKKSVDFIGVGTGPFNLSIAALSHQIEELNCLFFDEHPHFSWHPGMLVPDCHMQTVFLKDLVSAVAPTNPYSFVNYLVKHKKFYRFLTSRLRTVSREEFSDYLRWAAEDMNNLYFSHTVENIDFDKKSRLFLVQTSRGEYFAHNICLGTGKQPYLPPCVKHVTQSCFHASEMNLRRPDLSGKRITVVGGGQSGADLFLNALRGEWGEAAEINWVSRRNNFNALDEAAFADEYFTPEYISGFSGLKEDIRHQLLDEQKMTSDGITADSLLTIYRELYHRFEVLRKPRNIRLLPSRSVTTLESSGPGWRLLMEHHLDQGRESLESDVVIFATGYRSALPQILPSLMPLITMHDKNTFKVRDDFTLEWSGPKENNIFAVNASMQTHGIAEPQLSLMAWRSARILNRVLGRDLFDLSMPPALIQWRSGSRKKPQPEAASLTHYTANIQE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: iuc mutants are attenuated in chicken embryos and rabbit ileal loops (Wyckoff et al., 2009).
COG COG3486Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Wyckoff et al., 2009: Wyckoff EE, Boulette ML, Payne SM. Genetics and environmental regulation of Shigella iron transport systems. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2009; 22(1); 43-51. [PubMed: 19130265].