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phoP from Shigella flexneri 5 str. 8401

Victor ID 1802
Gene Name phoP from Shigella flexneri 5 str. 8401
Sequence Strain (Species/Organism) Shigella flexneri 5 str. 8401
NCBI Gene ID 4209107
NCBI Protein GI 110805158
Locus Tag SFV_1165
Protein Accession YP_688678.1
Other Database IDs UniProtKB-ID: Q0T5P2_SHIF8
UniRef100: UniRef100_Q8CXZ9
UniRef90: UniRef90_Q57QC3
UniRef50: UniRef50_Q5PMJ1
UniParc: UPI000000E0F8
EMBL: CP000266
EMBL-CDS: ABF03373.1
RefSeq_NT: NC_008258.1
EnsemblGenome: EBESCG00000095820.
EnsemblGenome_TRS: EBESCT00000096776
EnsemblGenome_PRO: EBESCP00000092972
GenomeReviews: CP000266_GR
KEGG: sfv:SFV_1165
eggNOG: COG0745
HOGENOM: HBG753323
OMA: HIEEVVA
ProtClustDB: PRK10816
BioCyc: SFLE373384:SFV_1165-MONOMER
Taxonomy ID 373384
Gene Starting Position 1209816
Gene Ending Position 1210487
Gene Strand (Orientation) -
Protein Name DNA-binding response regulator in two-component regulatory system with PhoQ
DNA Sequence 
>gi|110804074:1209816-1210487 Shigella flexneri 5 str. 8401, complete genome
ATCAGCGCAATTCGAACAGGTAGCCCTGGCCGCGAACGGTGGTAATGACTTCTTGCGGATATTGTGCCTG
AATTTTTTTGCGCAGACGTCCCATCAGTACATCAATGGTATGGCTTTCCCGCAGCTCCGCATCCGGATAG
AGTTGTAGCATTAACGAATCTTTGCTGACCACTTTGCCATTATTGCGTATCAACGTTTCCATAATGGTGT
ATTCGAACGCGGTCAGTTTGATCACTTCGTCATTAATAGATAATTCACGGCGAGAGAGATCAACCTGAAA
CGGGGGGAGCGAAATGACCTGTGAAGCCAGACCGCTATTACGCCGCATTAATGCCTGCATTCGCGCCATC
ACCTCTTCAATATGAAACGGTTTAGTCACGTAATCATCAGCACCGGCACTTAATACTTCGACTTTGTCCT
GCCAGCTTTCACGGGCGGTTAATACCAGAATCGGCAGTGAAACATCGTTGCTACGCCAGCGGCGAATCAG
TGACAGACCGTCCTCGTCAGGCAATCCGAGATCGACAATCGCAATATCCGGTAAATGTTCATTGAGATAA
TAATCGGCTTCTTTGGCATCTTCTGCGTCATCGACCTGATGACCAGCATCCTGAATCTGAACTTTAAGGT
GGTGACGTAACAACGCATTGTCTTCAACAACCAGTACGCGCA
Protein Sequence 
>gi|110805158|ref|YP_688678.1| DNA-binding transcriptional regulator PhoP [Shigella flexneri 5 str. 8401] MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNSGLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYPDAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: phoP mutants were resolved more quickly than wild type in animal models, and are more susceptible to killing by PMNs (Moss et al., 2000).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Moss et al., 2000: Moss JE, Fisher PE, Vick B, Groisman EA, Zychlinsky A. The regulatory protein PhoP controls susceptibility to the host inflammatory response in Shigella flexneri. Cellular microbiology. 2000; 2(6); 443-452. [PubMed: 11207599].