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aroD from Shigella flexneri 5 str. 8401

Victor ID 1798
Gene Name aroD from Shigella flexneri 5 str. 8401
Sequence Strain (Species/Organism) Shigella flexneri 5 str. 8401
NCBI Gene ID 4208482
NCBI Protein GI 110805672
Locus Tag SFV_1719
Protein Accession YP_689192.1
Other Database IDs UniProtKB-ID: AROD_SHIF8
UniRef100: UniRef100_Q0T478
UniRef90: UniRef90_A7ZMF8
UniRef50: UniRef50_Q186A6
UniParc: UPI000000E275
EMBL: CP000266
EMBL-CDS: ABF03887.1
RefSeq_NT: NC_008258.1
EnsemblGenome: EBESCG00000094278
EnsemblGenome_TRS: EBESCT00000095234
EnsemblGenome_PRO: EBESCP00000091430
GenomeReviews: CP000266_GR
KEGG: sfv:SFV_1719
eggNOG: COG0710
HOGENOM: HBG732926
OMA: NHDFDKT
ProtClustDB: PRK02412
BioCyc: SFLE373384:SFV_1719-MONOMER
Taxonomy ID 373384
Gene Starting Position 1756093
Gene Ending Position 1756851
Gene Strand (Orientation) +
Protein Name 3-dehydroquinate dehydratase
DNA Sequence 
>gi|110804074:1756093-1756851 Shigella flexneri 5 str. 8401, complete genome
AATGAAAACCGTAACTGTAAAAGATCTCGTCATTGGTGCGGGCGCACCTAAAATCATCGTCTCGCTGATG
GCGAAAGATATCGCCCGCGTGAAATCCGAAGCTCTCGCCTATCGTGAAGCGGACTTTGATATTCTGGAAT
GGCGTGTGGACCACTTTGCCGACCTCTCCAATGTGGAGTCTGTCATGGCGGCGGCAAAAATTCTCCGTGA
AACCATGCCAGAAAAACCGCTGCTGTTTACCTTCCGCAGTGCCAAAGAAGGCGGCGAGCAGGCGATTTCC
ACCGAGGCTTATATTGCTCTCAATCGTGCAGCCATCGACAGCGGCCTGGTTGATATGATCGATCTGGAGT
TATTTACCGGCGATGATCAGGTCAAAGAAACCGTCGCCTACGCCCACGCGCATGATGTGAAAGTTGTCAT
GTCCAACCATGACTTCCATAAAACGCCGGAAGCCGAAGAAATCATTGCCCGTCTGCGCAAAATGCAGTCC
TTCGACGCCGATATTCCTAAGATTGCGCTGATGCCGCAAAGTACCAGCGATGTGCTGACGTTGCTTGCCG
CGACCCTGGAGATGCAGGAGCAGTATGCCGATCGTCCAATCATCACGATGTCGATGGCAAAAACTGGCGT
AATTTCTCGTCTGGTTGGTGAAGTATTTGGCTCGGCGGCAACTTTTGGTGCGGTAAAAAAAGCCTCTGCG
CCAGGGCAAATCTCGGTAAATGATTTGCGCACGGTATTAACTATTTTACATCAGGCATA
Protein Sequence 
>gi|110805672|ref|YP_689192.1| 3-dehydroquinate dehydratase [Shigella flexneri 5 str. 8401] MKTVTVKDLVIGAGAPKIIVSLMAKDIARVKSEALAYREADFDILEWRVDHFADLSNVESVMAAAKILRETMPEKPLLFTFRSAKEGGEQAISTEAYIALNRAAIDSGLVDMIDLELFTGDDQVKETVAYAHAHDVKVVMSNHDFHKTPEAEEIIARLRKMQSFDADIPKIALMPQSTSDVLTLLAATLEMQEQYADRPIITMSMAKTGVISRLVGEVFGSAATFGAVKKASAPGQISVNDLRTVLTILHQA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: aroD deletion led to attenuation in HeLa cells and monkeys (Kärnell et al., 1993).
COG COG0710E, under E: Amino acid transport and metabolism
References
Kärnell et al., 1993: Kärnell A, Cam PD, Verma N, Lindberg AA. AroD deletion attenuates Shigella flexneri strain 2457T and makes it a safe and efficacious oral vaccine in monkeys. Vaccine. 1993; 11(8); 830-836. [PubMed: 8356844].