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gnd from Brucella melitensis biovar Abortus 2308

Victor ID 1771
Gene Name gnd from Brucella melitensis biovar Abortus 2308
Sequence Strain (Species/Organism) Brucella melitensis biovar Abortus 2308
NCBI Gene ID 3828241
NCBI Protein GI 83269060
Locus Tag BAB2_0109
Protein Accession YP_418351.1
Other Database IDs UniProtKB-ID: Q2YJ89_BRUA2
UniRef100: UniRef100_A5VTM2
UniRef90: UniRef90_A6X6S9
UniRef50: UniRef50_A6UA87
UniParc: UPI00000DD842
EMBL: AM040265
EMBL-CDS: CAJ12275.1
RefSeq_NT: NC_007624.1
GenomeReviews: AM040265_GR
KEGG: bmf:BAB2_0109
eggNOG: COG0362
HOGENOM: HBG286913
OMA: LQGQRDF
ProtClustDB: PRK09287
BioCyc: BMEL359391:BAB2_0109-MONOMER
Taxonomy ID 359391
Chromosome No II
Gene Starting Position 108148
Gene Ending Position 109557
Gene Strand (Orientation) +
Protein Name 6-phosphogluconate dehydrogenase
DNA Sequence 
>gi|83268957:108148-109557 Brucella melitensis biovar Abortus 2308 chromosome II, complete genome
AATGGAAAAAGCAGATATCGGAATGGTCGGCCTTGGCGTCATGGGCTCCAACCTGGCGCTGAACATAGCC
GAGAAGGGCTACACCGTGGCCGTCTATGACCGTGATGAGCCTGTGCTGAAAGCTTTCATCGAAAAGGCTG
GCCGGCTGCGCGACAAGATCATTCCCTGCCCGACCTTTGAGGAACTGGCCGCGAATATCCGCAAGCCCCG
TCCGATCATCTTTCTCATCAAGGCCGGTGCGCCAGTCGATACCGAGACCACCCGCCTCAAGGCATTCCTT
GAGAAGGGCGATATCATGATCGATGCAGGCAATTCCGATTATCGCGATACGGTGCGCCGCCTGAAGGCTC
TTGGCCCCAATGATCCGACCTTTGTCGGCATGGGCGTTTCGGGTGGGGCGGAAGGCGCGCGCCATGGTCC
GTCGATGATGGTCGGCGGCACGGAGCAGGCCTATGAGCGCATCGCGCCGATCCTGCTTGCTGTCGCCGCC
AAATATCAGGGCGAGCCCTGCTGTGCGCTGGTCGGCCCGGATGGCGCGGGTCATTTCGTCAAAACCATCC
ATAACGGTATTGAATATGCCGATATGCAGATGATCGCCGAAATTTACGGCATTCTGCGCGATGGCCTTGG
CCTTTCAGCTCCGGCCATCGGCGATGTGTTCGAGAAATGGAACGAAGGTCCGCTCAATTCCTATCTGATT
GAAATCACCGCCAAGGTTCTCAAGTCCACCGACCCGGAAACCGGCAAGGCGATGGTCGATATGATCCTTG
ATGAAGCCGGCCAGAAGGGTACAGGCCGCTGGGCTGCCATTGAGGCGCAGATACTGGGCGTTCCGGCCAC
GGGCATCGAAGCCGCGGTTGCCGCCCGTTCGCTGTCCTCCATGAAGGGCGAGCGGGAAGAGGCCGCCAAG
GCGTATAAATCCGGTGCACGCACACTTGATATTGCCAACCAGACCCGCTTCCTTTCCGATCTGGAACAGG
GCTTGCTGGCGGGCAAGATCGCCGCTTATGCGCAAGGCTTTGCAGTGATGGAAGCCGCCTCAAGGGAGCA
TGGCTGGAACATTCCGCTTGCCACCACGGCGCGCATCTGGCGCGCGGGCTGCATCATCCGCTCGCAGCTT
CTGGATGATATTGCGCAGGCTTTTGAAGGCAATGAAAGCCGCAACCTGCTCATGGCCCCGGCCTTCGTGC
CGCGCATGGAAACATCTGTGAAAAGCCTTCGCCAGATTGTCGCGCAGGCCGCCCTTGCCAGCCTGCCGCT
GCCCGCGCTCGGCTCTGCGCTCAGCTATTTCGACAGCTATACGCAGGCGCTTGGTACGGCCAATCTCATT
CAGGGCCAGCGCGATTTCTTCGGCTCGCACGGCTTCAAGCGCATTGACAAGGAGGGGGATTTCCACGGCC
CCTGGGGCTG
Protein Sequence 
>gi|83269060|ref|YP_418351.1| 6-phosphogluconate dehydrogenase [Brucella abortus 2308] MEKADIGMVGLGVMGSNLALNIAEKGYTVAVYDRDEPVLKAFIEKAGRLRDKIIPCPTFEELAANIRKPRPIIFLIKAGAPVDTETTRLKAFLEKGDIMIDAGNSDYRDTVRRLKALGPNDPTFVGMGVSGGAEGARHGPSMMVGGTEQAYERIAPILLAVAAKYQGEPCCALVGPDGAGHFVKTIHNGIEYADMQMIAEIYGILRDGLGLSAPAIGDVFEKWNEGPLNSYLIEITAKVLKSTDPETGKAMVDMILDEAGQKGTGRWAAIEAQILGVPATGIEAAVAARSLSSMKGEREEAAKAYKSGARTLDIANQTRFLSDLEQGLLAGKIAAYAQGFAVMEAASREHGWNIPLATTARIWRAGCIIRSQLLDDIAQAFEGNESRNLLMAPAFVPRMETSVKSLRQIVAQAALASLPLPALGSALSYFDSYTQALGTANLIQGQRDFFGSHGFKRIDKEGDFHGPWG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: gnd is involved in pentose phosphate pathway. It is essential for intracellular growth inside HeLa cells as shown by its Brucella suis miniTn5Km2 transposon mutation analysis. The mutant is attenuated in the mouse model (Kim et al., 2003).
COG COG0362G, under G: Carbohydrate transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].